M. Peter Marinkovich

Publication Details

  • Linear immunoglobulin A bullous dermatosis CLINICS IN DERMATOLOGY Fortuna, G., Marinkovich, M. P. 2012; 30 (1): 38-50

    Abstract:

    Linear immunoglobulin A (IgA) bullous dermatosis, also known as linear IgA disease, is an autoimmune mucocutaneous disorder characterized by subepithelial bullae, with IgA autoantibodies directed against several different antigens in the basement membrane zone. Its immunopathologic characteristic resides in the presence of a continuous linear IgA deposit along the basement membrane zone, which is clearly visible on direct immunofluorescence. This disorder shows different clinical features and distribution when adult-onset of linear IgA disease is compared with childhood-onset. Diagnosis is achieved via clinical, histopathologic, and immunopathologic examinations. Two common therapies are dapsone and sulfapyridine, which reduce the inflammatory response and achieve disease remission in a variable period of time.

    View details for DOI 10.1016/j.clindermatol.2011.03.008

    View details for Web of Science ID 000298212600005

    View details for PubMedID 22137225

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