Carl Feinstein

Publication Details

  • A CASE-REPORT OF NALTREXONE TREATMENT OF SELF-INJURY AND SOCIAL WITHDRAWAL IN AUTISM Walters, A. S., Barrett, R. P., Feinstein, C., Mercurio, A., Hole, W. T. PLENUM PUBL CORP. 1990: 169-176

    Abstract:

    The endogenous opiate release theory of self-injurious behavior (SIB) was investigated through double-blind placebo-controlled administration of naltrexone hydrochloride (Trexan) to a 14-year-old autistic and mentally retarded male for treatment of severe SIB. Results yielded a marked decrease in SIB during two phases of active drug treatment, though SIB did not revert to originally observed placebo levels during a second placebo phase. An increase in social relatedness also was observed during phases of active drug treatment. Opiate theories of self-injury and the possible interrelationship of self-injury with pituitary-adrenal arousal and with social relatedness are discussed.

    View details for Web of Science ID A1990DE71600002

    View details for PubMedID 2189867

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