Les Dorfman

Publication Details

  • Neurocognitive Impairment in Adults With Moyamoya Disease Without Stroke NEUROSURGERY Karzmark, P., Zeifert, P. D., Bell-Stephens, T. E., Steinberg, G. K., Dorfman, L. J. 2012; 70 (3): 634-638

    Abstract:

    Adults with moyamoya disease (MMD) have been shown to manifest cognitive impairment, but it is unclear whether this is the result of ischemic stroke.To determine whether adults with MMD but without stroke have cognitive impairment.We performed detailed neuropsychological assessments in 30 adults with angiographically confirmed MMD without magnetic resonance imaging (MRI) evidence of stroke.Twenty patients (67%) exhibited small T2 hyperintensities in the cerebral subcortical white matter on brain MRI but no evidence of gray matter damage. Significant cognitive impairment, defined as half of test scores ? 1 SD below the normal mean, was present in 7 patients (23%). Executive functioning, mental efficiency, and word finding were the ability areas most frequently impaired, whereas memory was relatively intact. Clinically significant emotional distress (depression and/or anxiety) was present in 11 patients (37%). Comparable cognitive findings were also observed in the subset of 10 patients (33%) with completely normal static brain MRI.Cognitive impairment in MMD can occur in the absence of ischemic stroke as manifested on MRI.

    View details for DOI 10.1227/NEU.0b013e3182320d1a

    View details for Web of Science ID 000300781700020

    View details for PubMedID 21849919

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