Yasodha Natkunam, M.D., Ph.D

Publication Details

  • Clinicopathologic and Molecular Features of 122 Brazilian Cases of Nodal and Extranodal NK/T-Cell Lymphoma, Nasal Type, With EBV Subtyping Analysis AMERICAN JOURNAL OF SURGICAL PATHOLOGY Gualco, G., Domeny-Duarte, P., Chioato, L., Barber, G., Natkunam, Y., Bacchi, C. E. 2011; 35 (8): 1195-1203

    Abstract:

    Extranodal natural killer/T-cell lymphoma, nasal type (NK/TCL) is more prevalent in Asia and in some areas of South and Central America, but it is rarely seen in the United States and Europe. In this study, a series of 122 cases of NK/TCL from Brazil was analyzed with respect to clinicopathologic features. Clinical characteristics and geographic distribution were evaluated in 97 cases of nasal/nasopharyngeal region and 23 cases in extranasal sites including 6 nodal cases. Clinical staging and follow-up information was available in a subset of 21 patients. All cases harbored Epstein-Barr virus (EBV), 95% and 85% expressed cytoplasmic CD3 and CD56, respectively, and all cases were positive for at least 1 marker for cytotoxic granules. The global distribution of EBV subtypes showed predominance of strain subtype A, 89%, and subtype B, 11%. No dual infections were detected. TCR-? TCR-gene rearrangement was observed in 7 cases; all of them extranodal. Three of TCR-?(+) cases showed EBV subtype A. Two TCR-?(+)/CD56(+) cases showed EBV subtype B. Geographic distribution of NK/TCL showed higher frequency in the southeast and northeast regions of Brazil. Striking differences among geographic regions were seen with the vast majority of EBV subtype B (86%) occurring in the south and southeast regions.

    View details for DOI 10.1097/PAS.0b013e31821ec4b5

    View details for Web of Science ID 000292728200014

    View details for PubMedID 21716086

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