Mark Hlatky, MD

Publication Details

  • Racial variation in lipoprotein-associated phospholipase A(2) in older adults BMC CARDIOVASCULAR DISORDERS Lee, K. K., Fortmann, S. P., Varady, A., Fair, J. M., Go, A. S., Quertermous, T., Hlatky, M. A., Iribarren, C. 2011; 11


    Lipoprotein-associated phospholipase A? (Lp-PLA?) is a predictor of cardiovascular events that has been shown to vary with race. The objective of this study was to examine factors associated with this racial variation.We measured Lp-PLA? mass and activity in 714 healthy older adults with no clinical coronary heart disease and not taking dyslipidemia medication. We evaluated the association between race and Lp-PLA? mass and activity levels after adjustment for various covariates using multivariable linear regression. These covariates included age, sex, diabetes, hypertension, body mass index, lipid measurements, C-reactive protein, smoking status, physical activity, diet, income, and education level. We further examined genetic covariates that included three single nucleotide polymorphisms shown to be associated with Lp-PLA? activity levels.The mean age was 66 years. Whites had the highest Lp-PLA? mass and activity levels, followed by Hispanics and Asians, and then African-Americans; in age and sex adjusted analyses, these differences were significant for each non-White race as compared to Whites (p < 0.0001). For example, African-Americans were predicted to have a 55.0 ng/ml lower Lp-PLA? mass and 24.7 nmol/ml-min lower activity, compared with Whites, independent of age and sex (p < 0.0001). After adjustment for all covariates, race remained significantly correlated with Lp-PLA? mass and activity levels (p < 0.001) with African-Americans having 44.8 ng/ml lower Lp-PLA? mass and 17.3 nmol/ml-min lower activity compared with Whites (p < 0.0001).Biological, lifestyle, demographic, and select genetic factors do not appear to explain variations in Lp-PLA? mass and activity levels between Whites and non-Whites, suggesting that Lp-PLA? mass and activity levels may need to be interpreted differently for various races.

    View details for DOI 10.1186/1471-2261-11-38

    View details for Web of Science ID 000293271500001

    View details for PubMedID 21714927

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