Julie Parsonnet

Publication Details

  • Local epidemic history as a predictor of tuberculosis incidence in Saskatchewan Aboriginal communities INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE Pepperell, C., Chang, A. H., Wobeser, W., Parsonnet, J., Hoeppner, V. H. 2011; 15 (7): 899-905


    Average tuberculosis (TB) incidence rates are high in Canadian Aboriginal communities, but there is significant variability within this group.To determine whether local history of post-contact TB epidemics is predictive of contemporary epidemiology among Aboriginal communities in Saskatchewan, Canada.TB incidence, age-specific morbidity patterns and rates of clustering of TB genotypes from 1986 to 2004 were compared between two groups of communities: Group 1, in which post-contact epidemics of TB were established around 1870, and Group 2, in which they were delayed until after 1920. Concomitant effects of socio-economic and geographic variables were explored with multivariate models.Group 2 communities were characterized by higher annual incidence of TB (median 431 per 100,000 population vs. 38/100,000). In multivariate models that included socio-economic and geographic variables, historical grouping remained a significant independent predictor of community incidence of TB. Clustering of TB genotypes was associated with Group 2 (OR 8.7, 95%CI 3.3-22.7) and age 10-34 years (OR 2.5, 95%CI 1.1-5.7).TB transmission dynamics can vary significantly as a function of a population's historical experience with TB. Populations at different stages along the epidemic trajectory may be amenable to different types of interventions.

    View details for DOI 10.5588/ijtld.10.0556

    View details for Web of Science ID 000292234000008

    View details for PubMedID 21682962

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