Samuel Strober

Publication Details

  • DEFICITS IN T HELPER-CELLS AFTER TOTAL LYMPHOID IRRADIATION (TLI) - REDUCED IL-2 SECRETION AND NORMAL IL-2 RECEPTOR EXPRESSION IN THE MIXED LEUKOCYTE REACTION (MLR) CELLULAR IMMUNOLOGY Bass, H., Strober, S. 1990; 126 (1): 129-142

    Abstract:

    Spleen cells from BALB/c mice treated with total lymphoid irradiation (TLI) and from normal, unirradiated mice were compared in the mixed leukocyte reaction (MLR). Although the percentage of CD4+ cells in the spleen was close to normal, 4 to 6 weeks after TLI, the MLR of unfractionated spleen cells from irradiated mice was more than 10-fold lower than controls. A similar reduction was observed when purified CD4+ cells were used as responders in the MLR. Secretion of IL-2 by cells from irradiated mice was also about 10-fold lower than controls. However, the percentage of CD4+ and CD8+ cells which expressed IL-2 surface receptors during the MLR was similar using spleen cells from irradiated and control mice. Addition of an exogenous source of IL-2 restored the proliferative capacity of the irradiated cells and suggests that the lack of IL-2 secretion is the likely explanation of the marked deficit in the MLR of CD4+ spleen cells after TLI.

    View details for Web of Science ID A1990CP72500011

    View details for PubMedID 2137375

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