Mark Nicolls

Publications

• Complement-mediated microvascular injury leads to chronic rejection. Khan MA, Nicolls MR. Adv Exp Med Biol. 2013: 735 233-46
• Developing better biomarkers for connective tissue disease-associated interstitial lung disease: citrullinated hsp90 autoantibodies in rheumatoid arthritis. Deane KD, Nicolls MR. Arthritis Rheum. 2013; 65 (4): 864-8
• Targeting complement component 5a promotes vascular integrity and limits airway remodeling. Khan MA, Maasch C, Vater A, Klussmann S, Morser J, Leung LL, Atkinson C, Tomlinson S, Heeger PS, Nicolls MR. Proc Natl Acad Sci U S A. 2013; 110 (15): 6061-6
• A brief overview of mouse models of pulmonary arterial hypertension: problems and prospects. Gomez-Arroyo J, Saleem SJ, Mizuno S, Syed AA, Bogaard HJ, Abbate A, Taraseviciene-Stewart L, Sung Y, Kraskauskas D, Farkas D, Conrad DH, Nicolls MR, Voelkel NF. Am J Physiol Lung Cell Mol Physiol. 2012; 302 (10): L977-91
• Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth. Hilgendorff A, Parai K, Ertsey R, Juliana Rey-Parra G, Thébaud B, Tamosiuniene R, Jain N, Navarro EF, Starcher BC, Nicolls MR, Rabinovitch M, Bland RD. Am J Physiol Lung Cell Mol Physiol. 2012; 303 (3): L215-27
• New methods for monitoring dynamic airway tissue oxygenation and perfusion in experimental and clinical transplantation. Khan MA, Dhillon G, Jiang X, Lin YC, Nicolls MR. Am J Physiol Lung Cell Mol Physiol. 2012; 303 (10): L861-9
• New models of pulmonary hypertension based on VEGF receptor blockade-induced endothelial cell apoptosis. Nicolls MR, Mizuno S, Taraseviciene-Stewart L, Farkas L, Drake JI, Al Husseini A, Gomez-Arroyo JG, Voelkel NF, Bogaard HJ. Pulm Circ. 2012; 2 (4): 434-42
• Pathobiology of pulmonary arterial hypertension and right ventricular failure. Voelkel NF, Gomez-Arroyo J, Abbate A, Bogaard HJ, Nicolls MR. Eur Respir J. 2012; 40 (6): 1555-65
• Potential for overuse of corticosteroids and vasopressin in septic shock. Hsu JL, Liu V, Patterson AJ, Martin GS, Nicolls MR, Russell JA. Crit Care. 2012; 16 (5): 447
• Severe pulmonary arterial hypertension induced by SU5416 and ovalbumin immunization. Mizuno S, Farkas L, Al Husseini A, Farkas D, Gomez-Arroyo J, Kraskauskas D, Nicolls MR, Cool CD, Bogaard HJ, Voelkel NF. Am J Respir Cell Mol Biol. 2012; 47 (5): 679-87
• Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection. Jiang X, Khan MA, Tian W, Beilke J, Natarajan R, Kosek J, Yoder MC, Semenza GL, Nicolls MR. J Clin Invest. 2011; 121 (6): 2336-49
• CD4+ T cells and complement independently mediate graft ischemia in the rejection of mouse orthotopic tracheal transplants. Khan MA, Jiang X, Dhillon G, Beilke J, Holers VM, Atkinson C, Tomlinson S, Nicolls MR. Circ Res. 2011; 109 (11): 1290-301
• Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice. Hilgendorff A, Parai K, Ertsey R, Jain N, Navarro EF, Peterson JL, Tamosiuniene R, Nicolls MR, Starcher BC, Rabinovitch M, Bland RD. Am J Respir Crit Care Med. 2011; 184 (5): 537-46
• Regulatory T cells and pulmonary hypertension. Tamosiuniene R, Nicolls MR. Trends Cardiovasc Med. 2011; 21 (6): 166-71
• Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension. Tamosiuniene R, Tian W, Dhillon G, Wang L, Sung YK, Gera L, Patterson AJ, Agrawal R, Rabinovitch M, Ambler K, Long CS, Voelkel NF, Nicolls MR. Circ Res. 2011; 109 (8): 867-79
• Bronchial blood supply after lung transplantation without bronchial artery revascularization. Nicolls MR, Zamora MR. Curr Opin Organ Transplant. 2010; 15 (5): 563-7
• Characterization of connective tissue disease-associated pulmonary arterial hypertension from REVEAL: identifying systemic sclerosis as a unique phenotype. Chung L, Liu J, Parsons L, Hassoun PM, McGoon M, Badesch DB, Miller DP, Nicolls MR, Zamanian RT. Chest. 2010; 138 (6): 1383-94
• Immunomodulatory strategies prevent the development of autoimmune emphysema. Hanaoka M, Nicolls MR, Fontenot AP, Kraskauskas D, Mack DG, Kratzer A, Salys J, Kraskauskiene V, Burns N, Voelkel NF, Taraseviciene-Stewart L. Respir Res. 2010: 11 179
• Lung transplant airway hypoxia: a diathesis to fibrosis? Dhillon GS, Zamora MR, Roos JE, Sheahan D, Sista RR, Van der Starre P, Weill D, Nicolls MR. Am J Respir Crit Care Med. 2010; 182 (2): 230-6
• Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report. Erzurum S, Rounds SI, Stevens T, Aldred M, Aliotta J, Archer SL, Asosingh K, Balaban R, Bauer N, Bhattacharya J, Bogaard H, Choudhary G, Dorn GW, Dweik R, Fagan K, Fallon M, Finkel T, Geraci M, Gladwin MT, Hassoun PM, Humbert M, Kaminski N, Kawut SM, Loscalzo J, McDonald D, McMurtry IF, Newman J, Nicolls M, Rabinovitch M, Shizuru J, Oka M, Polgar P, Rodman D, Schumacker P, Stenmark K, Tuder R, Voelkel N, Sullivan E, Weinshilboum R, Yoder MC, Zhao Y, Gail D, Moore TM. Am J Respir Crit Care Med. 2010; 182 (12): 1554-62
• Increased regulatory and decreased CD8+ cytotoxic T cells in the blood of patients with idiopathic pulmonary arterial hypertension. Ulrich S, Nicolls MR, Taraseviciene L, Speich R, Voelkel N. Respiration. 2008; 75 (3): 272-80
• Absence of T cells confers increased pulmonary arterial hypertension and vascular remodeling. Nicolls MR*, Taraseviciene-Stewart L, Kraskauskas D, Scerbavicius R, Burns N, Cool C, Wood K, Parr JE, Boackle SA, Voelkel NF (*co-1st author). Am J Respir Crit Care Med. 2007; 175 (12): 1280-9
• Angiogenesis in chronic lung disease. Voelkel NF, Douglas IS, Nicolls M. Chest. 2007; 131 (3): 874-9
• Endogenous signals released from necrotic cells augment inflammatory responses to bacterial endotoxin. El Mezayen R, El Gazzar M, Seeds MC, McCall CE, Dreskin SC, Nicolls MR. Immunol Lett. 2007; 111 (1): 36-44
• Hypoxia and the lung: beyond hypoxic vasoconstriction. Nicolls MR, Voelkel NF. Antioxid Redox Signal. 2007; 9 (6): 741-3
• Microvascular destruction identifies murine allografts that cannot be rescued from airway fibrosis. Babu AN, Murakawa T, Thurman JM, Miller EJ, Henson PM, Zamora MR, Voelkel NF, Nicolls MR. J Clin Invest. 2007; 117 (12): 3774-85
• Oxidant stress, immune dysregulation, and vascular function in type I diabetes. Nicolls MR, Haskins K, Flores SC. Antioxid Redox Signal. 2007; 9 (7): 879-89
• The matrix comes to lung transplantation. Babu AN, Nicolls MR. Transplantation. 2007; 83 (6): 683-4
• Thymoquinone attenuates proinflammatory responses in lipopolysaccharide-activated mast cells by modulating NF-kappaB nuclear transactivation. El Gazzar MA, El Mezayen R, Nicolls MR, Dreskin SC. Biochim Biophys Acta. 2007; 1770 (4): 556-64
• Transfer of allograft specific tolerance requires CD4+CD25+T cells but not interleukin-4 or transforming growth factor-beta and cannot induce tolerance to linked antigens. Hall BM, Plain KM, Verma ND, Tran GT, Boyd R, Robinson CM, Nicolls MR, Berger ME, Nomura M, Hodgkinson SJ. Transplantation. 2007; 83 (8): 1075-84
• Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation. El Gazzar M, El Mezayen R, Marecki JC, Nicolls MR, Canastar A, Dreskin SC. Int Immunopharmacol. 2006; 6 (7): 1135-42
• Downregulation of leukotriene biosynthesis by thymoquinone attenuates airway inflammation in a mouse model of allergic asthma. El Gazzar M, El Mezayen R, Nicolls MR, Marecki JC, Dreskin SC. Biochim Biophys Acta. 2006; 1760 (7): 1088-95
• Effect of thymoquinone on cyclooxygenase expression and prostaglandin production in a mouse model of allergic airway inflammation. El Mezayen R, El Gazzar M, Nicolls MR, Marecki JC, Dreskin SC, Nomiyama H. Immunol Lett. 2006; 106 (1): 72-81
• Is alveolar destruction and emphysema in chronic obstructive pulmonary disease an immune disease? Taraseviciene-Stewart L, Douglas IS, Nana-Sinkam PS, Lee JD, Tuder RM, Nicolls MR, Voelkel NF. Proc Am Thorac Soc. 2006; 3 (8): 687-90
• LFA-1 (CD11a) as a therapeutic target. Nicolls MR, Gill RG. Am J Transplant. 2006; 6 (1): 27-36
• Mechanisms of autoimmune emphysema. Taraseviciene-Stewart L, Burns N, Kraskauskas D, Nicolls MR, Tuder RM, Voelkel NF. Proc Am Thorac Soc. 2006; 3 (6): 486-7
• An animal model of autoimmune emphysema. Taraseviciene-Stewart L, Scerbavicius R, Choe KH, Moore M, Sullivan A, Nicolls MR, Fontenot AP, Tuder RM, Voelkel NF. Am J Respir Crit Care Med. 2005; 171 (7): 734-42
• Autoimmunity and pulmonary hypertension: a perspective. Nicolls MR, Taraseviciene-Stewart L, Rai PR, Badesch DB, Voelkel NF. Eur Respir J. 2005; 26 (6): 1110-8
• Chemokine-mediated angiogenesis: an essential link in the evolution of airway fibrosis? Douglas IS, Nicolls MR. J Clin Invest. 2005; 115 (5): 1133-6
• Simultaneous LFA-1 and CD40 ligand antagonism prevents airway remodeling in orthotopic airway transplantation: implications for the role of respiratory epithelium as a modulator of fibrosis. Murakawa T, Kerklo MM, Zamora MR, Wei Y, Gill RG, Henson PM, Grover FL, Nicolls MR. J Immunol. 2005; 174 (7): 3869-79
• The protective role of T-lymphocytes in pulmonary vascular remodeling. Taraseviciene-Stewart L, Scerbavicius DK, Burns N, Cool CD, Nicolls MR, Voelkel NF. Chest. 2005; 128 (6 Suppl): 571S-572S
• Type 2 diabetes mellitus as a conformational disease. Hayden MR, Tyagi SC, Kerklo MM, Nicolls MR. JOP. 2005; 6 (4): 287-302
• Following universal prophylaxis with intravenous ganciclovir and cytomegalovirus immune globulin, valganciclovir is safe and effective for prevention of CMV infection following lung transplantation. Zamora MR, Nicolls MR, Hodges TN, Marquesen J, Astor T, Grazia T, Weill D. Am J Transplant. 2004; 4 (10): 1635-42
• The clinical and biological relationship between Type II diabetes mellitus and Alzheimer's disease. Nicolls MR, Curr Alzheimer Res. 2004; 1 (1): 47-54
• Gene microarray study corroborates proteomic findings in rodent islet cells. Cardozo AK, Berthou L, Kruhøffer M, Orntoft T, Nicolls MR, Eizirik DL. J Proteome Res. 2003 Sep-Oct; 2 (5): 553-5
• Proteomics as a tool for discovery: proteins implicated in Alzheimer's disease are highly expressed in normal pancreatic islets. Nicolls MR, D'Antonio JM, Hutton JC, Gill RG, Czwornog JL, Duncan MW. J Proteome Res. 2003 Mar-Apr; 2 (2): 199-205
• CD4-dependent generation of dominant transplantation tolerance induced by simultaneous perturbation of CD154 and LFA-1 pathways. Nicolls MR, Coulombe M, Beilke J, Gelhaus HC, Gill RG. J Immunol. 2002; 169 (9): 4831-9
• Interferon-gamma is not a universal requirement for islet allograft survival. Nicolls MR, Coulombe M, Diamond AS, Beilke J, Gill RG. Transplantation. 2002; 74 (4): 472-7
• Reversal of experimental allergic encephalomyelitis with non-mitogenic, non-depleting anti-CD3 mAb therapy with a preferential effect on T(h)1 cells that is augmented by IL-4. Tran GT, Carter N, He XY, Spicer TS, Plain KM, Nicolls M, Hall BM, Hodgkinson SJ. Int Immunol. 2001; 13 (9): 1109-20
• The basis of immunogenicity of endocrine allografts. Nicolls MR, Coulombe M, Gill RG. Crit Rev Immunol. 2001; 21 (1-3): 87-101
• Anti-LFA-1 therapy induces long-term islet allograft acceptance in the absence of IFN-gamma or IL-4. Nicolls MR, Coulombe M, Yang H, Bolwerk A, Gill RG. J Immunol. 2000; 164 (7): 3627-34
• Diffuse alveolar hemorrhage with underlying pulmonary capillaritis in the retinoic acid syndrome. Nicolls MR, Terada LS, Tuder RM, Prindiville SA, Schwarz MI. Am J Respir Crit Care Med. 1998; 158 (4): 1302-5
• Induction of long-term specific tolerance to allografts in rats by therapy with an anti-CD3-like monoclonal antibody. Nicolls MR, Aversa GG, Pearce NW, Spinelli A, Berger MF, Gurley KE, Hall BM. Transplantation. 1993; 55 (3): 459-68
• Induction of tolerance to heart allografts in rats using posttransplant total lymphoid irradiation and anti-T cell antibodies. Woodley SL, Gurley KE, Hoffmann SL, Nicolls MR, Hagberg R, Clayberger C, Holm B, Wang X, Hall BM, Strober S. Transplantation. 1993; 56 (6): 1443-7