Kari Nadeau, MD, PhD

Publications

• Immunomodulatory effect of vancomycin on Treg in pediatric inflammatory bowel disease and primary sclerosing cholangitis. Abarbanel DN, Seki SM, Davies Y, Marlen N, Benavides JA, Cox K, Nadeau KC, Cox KL. J Clin Immunol. 2013; 33 (2): 397-406
• Markers of antigen presentation and activation on eosinophils and T cells in the esophageal tissue of patients with eosinophilic esophagitis. Le-Carlson M, Seki S, Abarbanel D, Quiros A, Cox K, Nadeau KC. J Pediatr Gastroenterol Nutr. 2013; 56 (3): 257-62
• Multiplex meta-analysis of RNA expression to identify genes with variants associated with immune dysfunction. Morgan AA, Pyrgos VJ, Nadeau KC, Williamson PR, Butte AJ. J Am Med Inform Assoc. 2012 Mar-Apr; 19 (2): 284-8
• Asthma discordance in twins is linked to epigenetic modifications of T cells. Runyon RS, Cachola LM, Rajeshuni N, Hunter T, Garcia M, Ahn R, Lurmann F, Krasnow R, Jack LM, Miller RL, Swan GE, Kohli A, Jacobson AC, Nadeau KC. PLoS One. 2012; 7 (11): e48796
• Epigenetic modifications and improved regulatory T-cell function in subjects undergoing dual sublingual immunotherapy. Swamy RS, Reshamwala N, Hunter T, Vissamsetti S, Santos CB, Baroody FM, Hwang PH, Hoyte EG, Garcia MA, Nadeau KC. J Allergy Clin Immunol. 2012; 130 (1): 215-24.e7
• Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients. Gernez Y, Tirouvanziam R, Reshamwala N, Yu G, Weldon BC, Galli SJ, Herzenberg LA, Nadeau KC. J Clin Immunol. 2012; 32 (3): 565-73
• Oral immunotherapy and anti-IgE antibody-adjunctive treatment for food allergy. Nadeau KC, Kohli A, Iyengar S, DeKruyff RH, Umetsu DT. Immunol Allergy Clin North Am. 2012; 32 (1): 111-33
• Personal omics profiling reveals dynamic molecular and medical phenotypes. Chen R, Mias GI, Li-Pook-Than J, Jiang L, Lam HY, Chen R, Miriami E, Karczewski KJ, Hariharan M, Dewey FE, Cheng Y, Clark MJ, Im H, Habegger L, Balasubramanian S, O'Huallachain M, Dudley JT, Hillenmeyer S, Haraksingh R, Sharon D, Euskirchen G, Lacroute P, Bettinger K, Boyle AP, Kasowski M, Grubert F, Seki S, Garcia M, Whirl-Carrillo M, Gallardo M, Blasco MA, Greenberg PL, Snyder P, Klein TE, Altman RB, Butte AJ, Ashley EA, Gerstein M, Nadeau KC, Tang H, Snyder M. Cell. 2012; 148 (6): 1293-307
• The STAT5b Pathway Defect and Autoimmunity. Kanai T, Jenks J, Nadeau KC. Front Immunol. 2012: 3 234
• The safety of peanut oral immunotherapy in peanut-allergic subjects in a single-center trial. Yu GP, Weldon B, Neale-May S, Nadeau KC. Int Arch Allergy Immunol. 2012; 159 (2): 179-82
• Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Gernez Y, Tirouvanziam R, Yu G, Ghosn EE, Reshamwala N, Nguyen T, Tsai M, Galli SJ, Herzenberg LA, Herzenberg LA, Nadeau KC. Int Arch Allergy Immunol. 2011; 154 (4): 318-27
• Genotype, phenotype, and outcomes of nine patients with T-B+NK+ SCID. Yu GP, Nadeau KC, Berk DR, de Saint Basile G, Lambert N, Knapnougel P, Roberts J, Kavanau K, Dunn E, Stiehm ER, Lewis DB, Umetsu DT, Puck JM, Cowan MJ. Pediatr Transplant. 2011; 15 (7): 733-41
• Immunophenotyping of peripheral eosinophils demonstrates activation in eosinophilic esophagitis. Nguyen T, Gernez Y, Fuentebella J, Patel A, Tirouvanziam R, Reshamwala N, Bass D, Berquist WE, Cox KL, Kerner JA, Nadeau KC. J Pediatr Gastroenterol Nutr. 2011; 53 (1): 40-7
• Rapid oral desensitization in combination with omalizumab therapy in patients with cow's milk allergy. Nadeau KC, Schneider LC, Hoyte L, Borras I, Umetsu DT. J Allergy Clin Immunol. 2011; 127 (6): 1622-4
• STAT5b Deficiency: An Unsuspected Cause of Growth Failure, Immunodeficiency, and Severe Pulmonary Disease Nadeau KC, Hwa V, Rosenfeld R. J Pediatr. 2011; 158 (5): 701-8
• Serum amyloid A overrides Treg anergy via monocyte-dependent and Treg-intrinsic, SOCS3-associated pathways. Nguyen KD, Macaubas C, Nadeau KC, Truong P, Yoon T, Lee T, Park JL, Mellins ED. Blood. 2011; 117 (14): 3793-8
• T(H)1, T(H)2, and T(H)17 cells instruct monocytes to differentiate into specialized dendritic cell subsets. Alonso MN, Wong MT, Zhang AL, Winer D, Suhoski MM, Tolentino LL, Gaitan J, Davidson MG, Kung TH, Galel DM, Nadeau KC, Kim J, Utz PJ, Söderström K, Engleman EG. Blood. 2011; 118 (12): 3311-20
• Ambient Air Pollution Impairs Regulatory T-Cell Function in Asthma. Nadeau KC, Hyman-McDonald C, Hammond K, Balmes J, Tager I. J Allergy Clin Immunol. 2010; 126 (4): 845-852
• Bradykinin Inhibitors in Hereditary Angioedema Nelson K, Nadeau KC. J Angioedema. 2010; 1 (1): 27-30
• Eotaxin and FGF enhance signaling through an extracellular signal-related kinase (ERK)-dependent pathway in the pathogenesis of Eosinophilic esophagitis. Huang JJ, Joh JW, Fuentebella J, Patel A, Nguyen T, Seki S, Hoyte L, Reshamwala N, Nguyen C, Quiros A, Bass D, Sibley E, Berquist W, Cox K, Kerner J, Nadeau KC. Allergy Asthma Clin Immunol. 2010; 6 (1): 25
• Epoprostenol-Associated Pneumonitis: Diagnostic Use of a T Cell Proliferation Assay Kudelko KT, De Jesus Perez V, Jaddad F, Zamanian RG, Nadeau KC, Leung A, Liu J. J Heart Lung Transplant. 2010; 29 (9): 1071-5
• Increased HLA-DR Expression on Tissue Eosinophils in Eosinophilic Esophagitis. Patel AJ, Fuentebella J, Gernez Y, Nguyen T, Bass D, Berquist W, Cox K, Sibley E, Kerner J, Nadeau KC. J Pediatr Gastroenterol Nutr. 2010; 51 (3): 290-4
• Increased Number of Regulatory T Cells in Children with Eosinophilic Esophagitis. Fuentebella J, Patel A, Nguyen T, Sanjanwala B, Berquist W, Kerner KA, Bass D, Cox K, Hurwitz M, Hung J, Nguyen C, Quiros JA, Nadeau KC. J Pediatr Gastroenterol Nutri. 2010; 51 (3): 283-9
• Individual variation in the germline Ig gene repertoire inferred from variable region gene rearrangements. Boyd SD, Gaëta BA, Jackson KJ, Fire AZ, Marshall EL, Merker JD, Maniar JM, Zhang LN, Sahaf B, Jones CD, Simen BB, Hanczaruk B, Nguyen KD, Nadeau KC, Egholm M, Miklos DB, Zehnder JL, Collins AM. J Immunol. 2010; 184 (12): 6986-92
• Migration of regulatory T cells toward airway epithelial cells is impaired in chronic rhinosinusitis with nasal polyposis. Kim YM, Munoz A, Hwang PH, Nadeau KC. Clin Immunol. 2010; 137 (1): 111-21
• TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway. Nguyen KD, Vanichsarn C, Nadeau KC. Allergy Asthma Clin Immunol. 2010; 6 (1): 4
• Impaired IL-10-dependent induction of tolerogenic dendritic cells by CD4+CD25hiCD127lo/- natural regulatory T cells in human allergic asthma. Nguyen KD, Vanichsarn C, Nadeau KC. Am J Respir Crit Care Med. 2009; 180 (9): 823-33
• Measurement and clinical monitoring of human lymphocyte clonality by massively parallel VDJ pyrosequencing. Boyd SD, Marshall EL, Merker JD, Maniar JM, Zhang LN, Sahaf B, Jones CD, Simen BB, Hanczaruk B, Nguyen KD, Nadeau KC, Egholm M, Miklos DB, Zehnder JL, Fire AZ. Sci Transl Med. 2009; 1 (12): 12ra23
• Neonatal alloimmune thrombocytopenia and neutropenia associated with maternal human leukocyte antigen antibodies. Gramatges MM, Fani P, Nadeau K, Pereira S, Jeng MR. Pediatr Blood Cancer. 2009; 53 (1): 97-9
• Regulatory T cell dysfunction in subjects with common variable immunodeficiency complicated by autoimmune disease. Yu GP, Chiang D, Song SJ, Hoyte EG, Huang J, Vanishsarn C, Nadeau KC. Clin Immunol. 2009; 131 (2): 240-53
• Selective deregulation in chemokine signaling pathways of CD4+CD25(hi)CD127(lo)/(-) regulatory T cells in human allergic asthma. Nguyen KD, Vanichsarn C, Fohner A, Nadeau KC. J Allergy Clin Immunol. 2009; 123 (4): 933-9.e10
• T Lymphocytes and Its Subsets in Transplanted Small Bowel Treated with Alemtuzumab (Campath-1H) Fuentebella J, Seki S, Nadeau KC, Castillo RO. Proc XI Int Small Bowel Transplant Sym. 2009: Dec 37-42
• A novel mutation associated with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy. Bhui RD, Lewis DB, Nadeau KC. Ann Allergy Asthma Immunol. 2008; 100 (2): 169
• Idiopathic neutropenia of childhood is associated with Fas/FasL expression. Nadeau KC, Callejas A, Wong WB, Joh JW, Cohen HJ, Jeng MR. Clin Immunol. 2008; 129 (3): 438-47
• Increased cytotoxicity of CD4+ invariant NKT cells against CD4+CD25hiCD127lo/- regulatory T cells in allergic asthma. Nguyen KD, Vanichsarn C, Nadeau KC. Eur J Immunol. 2008; 38 (7): 2034-45
• XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma. Nguyen KD, Fohner A, Booker JD, Dong C, Krensky AM, Nadeau KC. J Immunol. 2008; 181 (8): 5386-95
• Altered phosphorylated signal transducer and activator of transcription profile of CD4+CD161+ T cells in asthma: modulation by allergic status and oral corticosteroids. Gernez Y, Tirouvanziam R, Nguyen KD, Herzenberg LA, Krensky AM, Nadeau KC. J Allergy Clin Immunol. 2007; 120 (6): 1441-8
• Cutting edge: Decreased accumulation and regulatory function of CD4+ CD25(high) T cells in human STAT5b deficiency. Cohen AC, Nadeau KC, Tu W, Hwa V, Dionis K, Bezrodnik L, Teper A, Gaillard M, Heinrich J, Krensky AM, Rosenfeld RG, Lewis DB. J Immunol. 2006; 177 (5): 2770-4
• Lgl1 is suppressed in oxygen toxicity animal models of bronchopulmonary dysplasia and normalizes during recovery in air. Nadeau K, Jankov RP, Tanswell AK, Sweezey NB, Kaplan F. Pediatr Res. 2006; 59 (3): 389-95
• Successful conversion from conventional immunosuppression to anti-CD154 monoclonal antibody costimulatory molecule blockade in rhesus renal allograft recipients. Cho CS, Burkly LC, Fechner JH, Kirk AD, Oberley TD, Dong Y, Brunner KG, Peters D, Tenhoor CN, Nadeau K, Yagci G, Ishido N, Schultz JM, Tsuchida M, Hamawy MM, Knechtle SJ. Transplantation. 2001; 72 (4): 587-97
• Inhibition of CD40 ligand (CD154) in the treatment of factor VIII inhibitors. Ewenstein BM, Hoots WK, Lusher JM, DiMichele D, White GC, Adelman B, Nadeau K. Haematologica. 2000; 85 (10 Suppl): 35-9
• Renal allograft protection with losartan in Fisher-->Lewis rats: hemodynamics, macrophages, and cytokines. Ziai F, Nagano H, Kusaka M, Coito AJ, Troy JL, Nadeau KC, Rennke HG, Tilney NL, Brenner BM, MacKenzie HS. Kidney Int. 2000; 57 (6): 2618-25
• Cloning and characterization of the two enzymes responsible for trypanothione biosynthesis in Crithidia fasciculata. Tetaud E, Manai F, Barrett MP, Nadeau K, Walsh CT, Fairlamb AH. J Biol Chem. 1998; 273 (31): 19383-90
• Effects of explosive brain death on cytokine activation of peripheral organs in the rat. Takada M, Nadeau KC, Hancock WW, Mackenzie HS, Shaw GD, Waaga AM, Chandraker A, Sayegh MH, Tilney NL. Transplantation. 1998; 65 (12): 1533-42
• Influence of initial antigen-independent events on acute allograft rejection: inhibition by a soluble P-selectin ligand and low-dose cyclosporine in combination. Kusaka M, Nadeau KC, Takada M, Nagano H, Shaw GD, Tilney NL. Transplant Proc. 1998; 30 (4): 1027-8
• Late blockade of T cell costimulation interrupts progression of experimental chronic allograft rejection. Chandraker A, Azuma H, Nadeau K, Carpenter CB, Tilney NL, Hancock WW, Sayegh MH. J Clin Invest. 1998; 101 (11): 2309-18
• Early cellular and molecular changes in ischemia/reperfusion injury: inhibition by a selectin antagonist, P-selectin glycoprotein ligand-1. Takada M, Nadeau KC, Shaw GD, Tilney NL. Transplant Proc. 1997 Feb-Mar; 29 (1-2): 1324-5
• Inhibition of CD28-B7 T-cell costimulatory activation pathway affects intragraft cytokine and growth factor expression in chronic renal allograft rejection. Nadeau K, Azuma H, Chandraker A, Sayegh MH, Tilney NL. Transplant Proc. 1997 Feb-Mar; 29 (1-2): 1038
• Initial ischemia/reperfusion injury influences late functional and structural changes in the kidney. Azuma H, Nadeau K, Takada M, Tilney NL. Transplant Proc. 1997 Feb-Mar; 29 (1-2): 1528-9
• CD28-b7 blockade in organ dysfunction secondary to cold ischemia/reperfusion injury. Chandraker A, Takada M, Nadeau KC, Peach R, Tilney NL, Sayegh MH. Kidney Int. 1997; 52 (6): 1678-84
• Cellular and molecular predictors of chronic renal dysfunction after initial ischemia/reperfusion injury of a single kidney. Azuma H, Nadeau K, Takada M, Mackenzie HS, Tilney NL. Transplantation. 1997; 64 (2): 190-7
• Immigrating unaccompanied minors--a neglected minority? Nadeau K, Hannibal K, Sirkin S, Nightingale EO. West J Med. 1997; 166 (3): 221-2
• Infection-associated macrophage activation accelerates chronic renal allograft rejection in rats. Nagano H, Nadeau KC, Kusaka M, Heeman UW, Tilney NL. Transplantation. 1997; 64 (11): 1602-5
• Nephron mass modulates the hemodynamic, cellular, and molecular response of the rat renal allograft. Azuma H, Nadeau K, Mackenzie HS, Brenner BM, Tilney NL. Transplantation. 1997; 63 (4): 519-28
• Prevention of late renal changes after initial ischemia/reperfusion injury by blocking early selectin binding. Takada M, Nadeau KC, Shaw GD, Tilney NL. Transplantation. 1997; 64 (11): 1520-5
• Sequential cellular and molecular kinetics in acutely rejecting renal allografts in rats. Nagano H, Nadeau KC, Takada M, Kusaka M, Tilney NL. Transplantation. 1997; 63 (8): 1101-8
• The cytokine-adhesion molecule cascade in ischemia/reperfusion injury of the rat kidney. Inhibition by a soluble P-selectin ligand. Takada M, Nadeau KC, Shaw GD, Marquette KA, Tilney NL. J Clin Invest. 1997; 99 (11): 2682-90
• The role of the B7 costimulatory pathway in experimental cold ischemia/reperfusion injury. Takada M, Chandraker A, Nadeau KC, Sayegh MH, Tilney NL. J Clin Invest. 1997; 100 (5): 1199-203
• Unaccompanied children in detention in the US. Nadeau KC, Pediatrics. 1997; 99 (4): 653
• Blockade of T-cell costimulation prevents development of experimental chronic renal allograft rejection. Azuma H, Chandraker A, Nadeau K, Hancock WW, Carpenter CB, Tilney NL, Sayegh MH. Proc Natl Acad Sci U S A. 1996; 93 (22): 12439-44
• Inflammatory mediators, cells and their products in acute host alloresponsiveness. Tilney NL, Nadeau K. Ann Transplant. 1996; 1 (3): 5-13
• Sequential cytokine expression in renal allografts in rats immunosuppressed with maintenance cyclosporine or mycophenolate mofetil. Nadeau KC, Azuma H, Tilney NL. Transplantation. 1996; 62 (9): 1363-6
• Prevention of functional, structural, and molecular changes of chronic rejection of rat renal allografts by a specific macrophage inhibitor. Azuma H, Nadeau KC, Ishibashi M, Tilney NL. Transplantation. 1995; 60 (12): 1577-82
• Sequential cytokine dynamics in chronic rejection of rat renal allografts: roles for cytokines RANTES and MCP-1. Nadeau KC, Azuma H, Tilney NL. Proc Natl Acad Sci U S A. 1995; 92 (19): 8729-33
• Molecular and biochemical comparison of the 70-kDa heat shock proteins of Trypanosoma cruzi. Olson CL, Nadeau KC, Sullivan MA, Winquist AG, Donelson JE, Walsh CT, Engman DM. J Biol Chem. 1994; 269 (5): 3868-74
• Quantitation of the interaction of the immunosuppressant deoxyspergualin and analogs with Hsc70 and Hsp90. Nadeau K, Nadler SG, Saulnier M, Tepper MA, Walsh CT. Biochemistry. 1994; 33 (9): 2561-7
• Hsp90 chaperonins possess ATPase activity and bind heat shock transcription factors and peptidyl prolyl isomerases. Nadeau K, Das A, Walsh CT. J Biol Chem. 1993; 268 (2): 1479-87
• Studies on the interaction of the immunosuppressant 15-deoxyspergualin with heat shock proteins. Nadler SG, Cleaveland J, Tepper MA, Walsh C, Nadeau K. Ann N Y Acad Sci. 1993: 696 412-4
• 83-kilodalton heat shock proteins of trypanosomes are potent peptide-stimulated ATPases. Nadeau K, Sullivan MA, Bradley M, Engman DM, Walsh CT. Protein Sci. 1992; 1 (8): 970-9
• Kinetic isotope effect analysis of the reaction catalyzed by Trypanosoma congolense trypanothione reductase. Leichus BN, Bradley M, Nadeau K, Walsh CT, Blanchard JS. Biochemistry. 1992; 31 (28): 6414-20
• Molecular studies on trypanothione reductase: an antiparasitic target enzyme. Walsh C, Bradley M, Nadeau K. Curr Top Cell Regul. 1992: 33 409-17
• Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata. Smith K, Nadeau K, Bradley M, Walsh C, Fairlamb AH. Protein Sci. 1992; 1 (7): 874-83
• A test for genetic exchange in mixed infections of Leishmania major in the sand fly Phlebotomus papatasi. Panton LJ, Tesh RB, Nadeau KC, Beverley SM. J Protozool. 1991 May-Jun; 38 (3): 224-8
• Molecular studies on trypanothione reductase, a target for antiparasitic drugs. Walsh C, Bradley M, Nadeau K. Trends Biochem Sci. 1991; 16 (8): 305-9
• The promoter of the latency-associated transcripts of herpes simplex virus type 1 contains a functional cAMP-response element: role of the latency-associated transcripts and cAMP in reactivation of viral latency. Leib DA, Nadeau KC, Rundle SA, Schaffer PA. Proc Natl Acad Sci U S A. 1991; 88 (1): 48-52