Cristina M. Alvira

Publications

• Inhibiting NF-κB in the developing lung disrupts angiogenesis and alveolarization. Iosef C, Alastalo TP, Hou Y, Chen C, Adams ES, Lyu SC, Cornfield DN, Alvira CM. Am J Physiol Lung Cell Mol Physiol. 2012; 302 (10): L1023-36
• Voltage-dependent anion channel-2 interaction with nitric oxide synthase enhances pulmonary artery endothelial cell nitric oxide production. Alvira CM, Umesh A, Husted C, Ying L, Hou Y, Lyu SC, Nowak J, Cornfield DN. Am J Respir Cell Mol Biol. 2012; 47 (5): 669-78
• Inhibition of transforming growth factor β worsens elastin degradation in a murine model of Kawasaki disease. Alvira CM, Guignabert C, Kim YM, Chen C, Wang L, Duong TT, Yeung RS, Li DY, Rabinovitch M. Am J Pathol. 2011; 178 (3): 1210-20
• Rho kinase modulates postnatal adaptation of the pulmonary circulation through separate effects on pulmonary artery endothelial and smooth muscle cells. Alvira CM, Sukovich DJ, Lyu SC, Cornfield DN. Am J Physiol Lung Cell Mol Physiol. 2010; 299 (6): L872-8
• Nuclear factor-kappaB activation in neonatal mouse lung protects against lipopolysaccharide-induced inflammation. Alvira CM, Abate A, Yang G, Dennery PA, Rabinovitch M. Am J Respir Crit Care Med. 2007; 175 (8): 805-15
• Hypoxia-inducible factor-1α in pulmonary artery smooth muscle cells lowers vascular tone by decreasing Myosin light chain phosphorylation. Kim YM, Barnes EA, Alvira CM, Ying L, Reddy S, Cornfield DN. Circ Res. 2013; 112 (9): 1230-3
• Hypoxia-inducible factor-1α regulates KCNMB1 expression in human pulmonary artery smooth muscle cells. Ahn YT, Kim YM, Adams E, Lyu SC, Alvira CM, Cornfield DN. Am J Physiol Lung Cell Mol Physiol. 2012; 302 (3): L352-9
• miR-29b participates in early aneurysm development in Marfan syndrome. Merk DR, Chin JT, Dake BA, Maegdefessel L, Miller MO, Kimura N, Tsao PS, Iosef C, Berry GJ, Mohr FW, Spin JM, Alvira CM, Robbins RC, Fischbein MP. Circ Res. 2012; 110 (2): 312-24
• Neutrophil elastase is produced by pulmonary artery smooth muscle cells and is linked to neointimal lesions. Kim YM, Haghighat L, Spiekerkoetter E, Sawada H, Alvira CM, Wang L, Acharya S, Rodriguez-Colon G, Orton A, Zhao M, Rabinovitch M. Am J Pathol. 2011; 179 (3): 1560-72
• Prolonged mechanical ventilation with air induces apoptosis and causes failure of alveolar septation and angiogenesis in lungs of newborn mice. Mokres LM, Parai K, Hilgendorff A, Ertsey R, Alvira CM, Rabinovitch M, Bland RD. Am J Physiol Lung Cell Mol Physiol. 2010; 298 (1): L23-35
• LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor. Ying L, Lau A, Alvira CM, West R, Cann GM, Zhou B, Kinnear C, Jan E, Sarnow P, Van de Rijn M, Rabinovitch M. J Cell Sci. 2009; 122 (Pt 9): 1441-51
• Tie2-mediated loss of peroxisome proliferator-activated receptor-gamma in mice causes PDGF receptor-beta-dependent pulmonary arterial muscularization. Guignabert C, Alvira CM, Alastalo TP, Sawada H, Hansmann G, Zhao M, Wang L, El-Bizri N, Rabinovitch M. Am J Physiol Lung Cell Mol Physiol. 2009; 297 (6): L1082-90
• An antiproliferative BMP-2/PPARgamma/apoE axis in human and murine SMCs and its role in pulmonary hypertension. Hansmann G, de Jesus Perez VA, Alastalo TP, Alvira CM, Guignabert C, Bekker JM, Schellong S, Urashima T, Wang L, Morrell NW, Rabinovitch M. J Clin Invest. 2008; 118 (5): 1846-57
• Mechanical ventilation uncouples synthesis and assembly of elastin and increases apoptosis in lungs of newborn mice. Prelude to defective alveolar septation during lung development? Bland RD, Ertsey R, Mokres LM, Xu L, Jacobson BE, Jiang S, Alvira CM, Rabinovitch M, Shinwell ES, Dixit A. Am J Physiol Lung Cell Mol Physiol. 2008; 294 (1): L3-14
• Reactivation of gammaHV68 induces neointimal lesions in pulmonary arteries of S100A4/Mts1-overexpressing mice in association with degradation of elastin. Spiekerkoetter E, Alvira CM, Kim YM, Bruneau A, Pricola KL, Wang L, Ambartsumian N, Rabinovitch M. Am J Physiol Lung Cell Mol Physiol. 2008; 294 (2): L276-89