Karl Deisseroth

Publications

• Driving fast-spiking cells induces gamma rhythm and controls sensory responses. Cardin JA, Carlén M, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore CI. Nature. 2009; 459 (7247): 663-7
• Optical deconstruction of parkinsonian neural circuitry. Gradinaru V, Mogri M, Thompson KR, Henderson JM, Deisseroth K. Science. 2009; 324 (5925): 354-9
• Parvalbumin neurons and gamma rhythms enhance cortical circuit performance. Sohal VS, Zhang F, Yizhar O, Deisseroth K. Nature. 2009; 459 (7247): 698-702
• Phasic firing in dopaminergic neurons is sufficient for behavioral conditioning. Tsai HC, Zhang F, Adamantidis A, Stuber GD, Bonci A, de Lecea L, Deisseroth K. Science. 2009; 324 (5930): 1080-4
• Temporally precise in vivo control of intracellular signalling. Airan RD, Thompson KR, Fenno LE, Bernstein H, Deisseroth K. Nature. 2009; 458 (7241): 1025-9
• Bi-stable neural state switches. Berndt A, Yizhar O, Gunaydin LA, Hegemann P, Deisseroth K. Nat Neurosci. 2009; 12 (2): 229-34
• Brain circuit dynamics. Hu ES, Airan RD, Vijaykumar R, Deisseroth K. Am J Psychiatry. 2008; 165 (7): 800
• Controlling neuronal activity. Schneider MB, Gradinaru V, Zhang F, Deisseroth K. Am J Psychiatry. 2008; 165 (5): 562
• Escape behavior elicited by single, channelrhodopsin-2-evoked spikes in zebrafish somatosensory neurons. Douglass AD, Kraves S, Deisseroth K, Schier AF, Engert F. Curr Biol. 2008; 18 (15): 1133-7
• Improved expression of halorhodopsin for light-induced silencing of neuronal activity. Zhao S, Cunha C, Zhang F, Liu Q, Gloss B, Deisseroth K, Augustine GJ, Feng G. Brain Cell Biol. 2008; 36 (1-4): 141-54
• Red-shifted optogenetic excitation: a tool for fast neural control derived from Volvox carteri. Zhang F, Prigge M, Beyrière F, Tsunoda SP, Mattis J, Yizhar O, Hegemann P, Deisseroth K. Nat Neurosci. 2008; 11 (6): 631-3
• eNpHR: a Natronomonas halorhodopsin enhanced for optogenetic applications. Gradinaru V, Thompson KR, Deisseroth K. Brain Cell Biol. 2008; 36 (1-4): 129-39
• An optical neural interface: in vivo control of rodent motor cortex with integrated fiberoptic and optogenetic technology. Aravanis AM, Wang LP, Zhang F, Meltzer LA, Mogri MZ, Schneider MB, Deisseroth K. J Neural Eng. 2007; 4 (3): S143-56
• Circuit-breakers: optical technologies for probing neural signals and systems. Zhang F, Aravanis AM, Adamantidis A, de Lecea L, Deisseroth K. Nat Rev Neurosci. 2007; 8 (8): 577-81
• High-speed imaging reveals neurophysiological links to behavior in an animal model of depression. Airan RD, Meltzer LA, Roy M, Gong Y, Chen H, Deisseroth K. Science. 2007; 317 (5839): 819-23
• High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. Wang H, Peca J, Matsuzaki M, Matsuzaki K, Noguchi J, Qiu L, Wang D, Zhang F, Boyden E, Deisseroth K, Kasai H, Hall WC, Feng G, Augustine GJ. Proc Natl Acad Sci U S A. 2007; 104 (19): 8143-8
• In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Arenkiel BR, Peca J, Davison IG, Feliciano C, Deisseroth K, Augustine GJ, Ehlers MD, Feng G. Neuron. 2007; 54 (2): 205-18
• Integration of light-controlled neuronal firing and fast circuit imaging. Airan RD, Hu ES, Vijaykumar R, Roy M, Meltzer LA, Deisseroth K. Curr Opin Neurobiol. 2007; 17 (5): 587-92
• Multimodal fast optical interrogation of neural circuitry. Zhang F, Wang LP, Brauner M, Liewald JF, Kay K, Watzke N, Wood PG, Bamberg E, Nagel G, Gottschalk A, Deisseroth K. Nature. 2007; 446 (7136): 633-9
• Neural substrates of awakening probed with optogenetic control of hypocretin neurons. Adamantidis AR, Zhang F, Aravanis AM, Deisseroth K, de Lecea L. Nature. 2007; 450 (7168): 420-4
• Nociceptive neurons protect Drosophila larvae from parasitoid wasps. Hwang RY, Zhong L, Xu Y, Johnson T, Zhang F, Deisseroth K, Tracey WD. Curr Biol. 2007; 17 (24): 2105-16
• Targeting and readout strategies for fast optical neural control in vitro and in vivo. Gradinaru V, Thompson KR, Zhang F, Mogri M, Kay K, Schneider MB, Deisseroth K. J Neurosci. 2007; 27 (52): 14231-8
• Channelrhodopsin-2 and optical control of excitable cells. Zhang F, Wang LP, Boyden ES, Deisseroth K. Nat Methods. 2006; 3 (10): 785-92
• Next-generation optical technologies for illuminating genetically targeted brain circuits. Deisseroth K, Feng G, Majewska AK, Miesenböck G, Ting A, Schnitzer MJ. J Neurosci. 2006; 26 (41): 10380-6
• A role for circuit homeostasis in adult neurogenesis. Meltzer LA, Yabaluri R, Deisseroth K. Trends Neurosci. 2005; 28 (12): 653-60
• GABA excitation in the adult brain: a mechanism for excitation- neurogenesis coupling. Deisseroth K, Malenka RC. Neuron. 2005; 47 (6): 775-7
• Millisecond-timescale, genetically targeted optical control of neural activity. Boyden ES, Zhang F, Bamberg E, Nagel G, Deisseroth K. Nat Neurosci. 2005; 8 (9): 1263-8
• Excitation-neurogenesis coupling in adult neural stem/progenitor cells. Deisseroth K, Singla S, Toda H, Monje M, Palmer TD, Malenka RC. Neuron. 2004; 42 (4): 535-52
• Signaling from synapse to nucleus: the logic behind the mechanisms. Deisseroth K, Mermelstein PG, Xia H, Tsien RW. Curr Opin Neurobiol. 2003; 13 (3): 354-65
• Dynamic multiphosphorylation passwords for activity-dependent gene expression. Deisseroth K, Tsien RW. Neuron. 2002; 34 (2): 179-82
• Activity-dependent CREB phosphorylation: convergence of a fast, sensitive calmodulin kinase pathway and a slow, less sensitive mitogen-activated protein kinase pathway. Wu GY, Deisseroth K, Tsien RW. Proc Natl Acad Sci U S A. 2001; 98 (5): 2808-13
• Calmodulin priming: nuclear translocation of a calmodulin complex and the memory of prior neuronal activity. Mermelstein PG, Deisseroth K, Dasgupta N, Isaksen AL, Tsien RW. Proc Natl Acad Sci U S A. 2001; 98 (26): 15342-7
• Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology. Wu GY, Deisseroth K, Tsien RW. Nat Neurosci. 2001; 4 (2): 151-8
• Critical dependence of cAMP response element-binding protein phosphorylation on L-type calcium channels supports a selective response to EPSPs in preference to action potentials. Mermelstein PG, Bito H, Deisseroth K, Tsien RW. J Neurosci. 2000; 20 (1): 266-73
• Calmodulin supports both inactivation and facilitation of L-type calcium channels. Zühlke RD, Pitt GS, Deisseroth K, Tsien RW, Reuter H. Nature. 1999; 399 (6732): 159-62
• L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW, Crabtree GR. Nature. 1999; 401 (6754): 703-8
• Translocation of calmodulin to the nucleus supports CREB phosphorylation in hippocampal neurons. Deisseroth K, Heist EK, Tsien RW. Nature. 1998; 392 (6672): 198-202
• Ca2+-dependent regulation in neuronal gene expression. Bito H, Deisseroth K, Tsien RW. Curr Opin Neurobiol. 1997; 7 (3): 419-29
• CREB phosphorylation and dephosphorylation: a Ca(2+)- and stimulus duration-dependent switch for hippocampal gene expression. Bito H, Deisseroth K, Tsien RW. Cell. 1996; 87 (7): 1203-14
• Signaling from synapse to nucleus: postsynaptic CREB phosphorylation during multiple forms of hippocampal synaptic plasticity. Deisseroth K, Bito H, Tsien RW. Neuron. 1996; 16 (1): 89-101
• Synaptic plasticity: A molecular mechanism for metaplasticity. Deisseroth K, Bito H, Schulman H, Tsien RW. Curr Biol. 1995; 5 (12): 1334-8
• Cross-resistance of an amsacrine-resistant human leukemia line to topoisomerase II reactive DNA intercalating agents. Evidence for two topoisomerase II directed drug actions. Zwelling LA, Mayes J, Hinds M, Chan D, Altschuler E, Carroll B, Parker E, Deisseroth K, Radcliffe A, Seligman M. Biochemistry. 1991; 30 (16): 4048-55
• Identification of a point mutation in the topoisomerase II gene from a human leukemia cell line containing an amsacrine-resistant form of topoisomerase II. Hinds M, Deisseroth K, Mayes J, Altschuler E, Jansen R, Ledley FD, Zwelling LA. Cancer Res. 1991; 51 (17): 4729-31
• A restriction fragment length polymorphism for human topoisomerase II: possible relationship to drug-resistance. Zwelling LA, Mayes J, Deisseroth K, Hinds M, Grant G, Pathak S, Ledley FD, Vyas R, Hittelman W. Cancer Commun. 1990; 2 (11): 357-61