William Robinson

Publications

• Blood autoantibody and cytokine profiles predict response to anti-tumor necrosis factor therapy in rheumatoid arthritis. Hueber W, Tomooka BH, Batliwalla F, Li W, Monach PA, Tibshirani RJ, Van Vollenhoven RF, Lampa J, Saito K, Tanaka Y, Genovese MC, Klareskog L, Gregersen PK, Robinson WH. Arthritis Res Ther. 2009; 11 (3): R76
• Molecular framework for response to imatinib mesylate in systemic sclerosis. Chung L, Fiorentino DF, Benbarak MJ, Adler AS, Mariano MM, Paniagua RT, Milano A, Connolly MK, Ratiner BD, Wiskocil RL, Whitfield ML, Chang HY, Robinson WH. Arthritis Rheum. 2009; 60 (2): 584-91
• Tyrosine kinases as targets for the treatment of rheumatoid arthritis. D'Aura Swanson C, Paniagua RT, Lindstrom TM, Robinson WH. Nat Rev Rheumatol. 2009; 5 (6): 317-24
• Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Han MH, Hwang SI, Roy DB, Lundgren DH, Price JV, Ousman SS, Fernald GH, Gerlitz B, Robinson WH, Baranzini SE, Grinnell BW, Raine CS, Sobel RA, Han DK, Steinman L. Nature. 2008; 451 (7182): 1076-81
• Lipid microarrays identify key mediators of autoimmune brain inflammation. Kanter JL, Narayana S, Ho PP, Catz I, Warren KG, Sobel RA, Steinman L, Robinson WH. Nat Med. 2006; 12 (1): 138-43
• Selective tyrosine kinase inhibition by imatinib mesylate for the treatment of autoimmune arthritis. Paniagua RT, Sharpe O, Ho PP, Chan SM, Chang A, Higgins JP, Tomooka BH, Thomas FM, Song JJ, Goodman SB, Lee DM, Genovese MC, Utz PJ, Steinman L, Robinson WH. J Clin Invest. 2006; 116 (10): 2633-42
• Citrullination within the atherosclerotic plaque: A potential target for the anti-citrullinated protein antibody response in rheumatoid arthritis. Sokolove J, Sharpe O, Brennan M, Lahey LJ, Kao AH, Krishnan E, Edmundowicz D, Lepus CM, Wasko MC, Robinson WH. Arthritis Rheum. 2013
• Serum autoantibodies to myelin peptides distinguish acute disseminated encephalomyelitis from relapsing- remitting multiple sclerosis. Van Haren K, Tomooka BH, Kidd BA, Banwell B, Bar-Or A, Chitnis T, Tenembaum SN, Pohl D, Rostasy K, Dale RC, O'Connor KC, Hafler DA, Steinman L, Robinson WH. Mult Scler. 2013
• Autoantibody epitope spreading in the pre-clinical phase predicts progression to rheumatoid arthritis. Sokolove J, Bromberg R, Deane KD, Lahey LJ, Derber LA, Chandra PE, Edison JD, Gilliland WR, Tibshirani RJ, Norris JM, Holers VM, Robinson WH. PLoS One. 2012; 7 (5): e35296
• Development and deployment of antigen arrays for investigation of B-cell fine specificity in autoimmune disease. Sokolove J, Lindstrom TM, Robinson WH. Front Biosci (Elite Ed). 2012: 4 320-30
• Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis. Lin JT, Stein EA, Wong MT, Kalpathy KJ, Su LL, Utz PJ, Robinson WH, Fathman CG. Clin Immunol. 2012; 142 (2): 127-38
• Identification of naturally occurring fatty acids of the myelin sheath that resolve neuroinflammation. Ho PP, Kanter JL, Johnson AM, Srinagesh HK, Chang EJ, Purdy TM, van Haren K, Wikoff WR, Kind T, Khademi M, Matloff LY, Narayana S, Hur EM, Lindstrom TM, He Z, Fiehn O, Olsson T, Han X, Han MH, Steinman L, Robinson WH. Sci Transl Med. 2012; 4 (137): 137ra73
• Inhibition of epidermal growth factor receptor tyrosine kinase ameliorates collagen-induced arthritis. Swanson CD, Akama-Garren EH, Stein EA, Petralia JD, Ruiz PJ, Edalati A, Lindstrom TM, Robinson WH. J Immunol. 2012; 188 (7): 3513-21
• New tools for classification and monitoring of autoimmune diseases. Maecker HT, Lindstrom TM, Robinson WH, Utz PJ, Hale M, Boyd SD, Shen-Orr SS, Fathman CG. Nat Rev Rheumatol. 2012; 8 (6): 317-28
• Response to 'Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4' - authors' reply. Sohn DH, Sokolove J, Sharpe O, Erhart JC, Chandra PE, Lahey LJ, Lindstrom TM, Hwang I, Boyer KA, Andriacchi TP, Robinson WH. Arthritis Res Ther. 2012; 14 (5): 406
• Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins. Rothbard JB, Kurnellas MP, Brownell S, Adams CM, Su L, Axtell RC, Chen R, Fathman CG, Robinson WH, Steinman L. J Biol Chem. 2012; 287 (13): 9708-21
• Chaperone activity of α B-crystallin is responsible for its incorrect assignment as an autoantigen in multiple sclerosis. Rothbard JB, Zhao X, Sharpe O, Strohman MJ, Kurnellas M, Mellins ED, Robinson WH, Steinman L. J Immunol. 2011; 186 (7): 4263-8
• Chemerin158K protein is the dominant chemerin isoform in synovial and cerebrospinal fluids but not in plasma. Zhao L, Yamaguchi Y, Sharif S, Du XY, Song JJ, Lee DM, Recht LD, Robinson WH, Morser J, Leung LL. J Biol Chem. 2011; 286 (45): 39520-7
• Fishing for biomarkers with antigen mimics. Lindstrom TM, Robinson WH. Cell. 2011; 144 (1): 13-5
• Human peptidome display. Robinson WH, Steinman L. Nat Biotechnol. 2011; 29 (6): 500-2
• Identification of a central role for complement in osteoarthritis. Wang Q, Rozelle AL, Lepus CM, Scanzello CR, Song JJ, Larsen DM, Crish JF, Bebek G, Ritter SY, Lindstrom TM, Hwang I, Wong HH, Punzi L, Encarnacion A, Shamloo M, Goodman SB, Wyss-Coray T, Goldring SR, Banda NK, Thurman JM, Gobezie R, Crow MK, Holers VM, Lee DM, Robinson WH. Nat Med. 2011; 17 (12): 1674-9
• Immune complexes containing citrullinated fibrinogen costimulate macrophages via Toll-like receptor 4 and Fcγ receptor. Sokolove J, Zhao X, Chandra PE, Robinson WH. Arthritis Rheum. 2011; 63 (1): 53-62
• Novel multiplex technology for diagnostic characterization of rheumatoid arthritis. Chandra PE, Sokolove J, Hipp BG, Lindstrom TM, Elder JT, Reveille JD, Eberl H, Klause U, Robinson WH. Arthritis Res Ther. 2011; 13 (3): R102
• Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis. Song JJ, Hwang I, Cho KH, Garcia MA, Kim AJ, Wang TH, Lindstrom TM, Lee AT, Nishimura T, Zhao L, Morser J, Nesheim M, Goodman SB, Lee DM, Bridges SL, Gregersen PK, Leung LL, Robinson WH. J Clin Invest. 2011; 121 (9): 3517-27
• Role of the Toll-like receptor pathway in the recognition of orthopedic implant wear-debris particles. Pearl JI, Ma T, Irani AR, Huang Z, Robinson WH, Smith RL, Goodman SB. Biomaterials. 2011; 32 (24): 5535-42
• Tyrosine kinase inhibitors ameliorate autoimmune encephalomyelitis in a mouse model of multiple sclerosis. Crespo O, Kang SC, Daneman R, Lindstrom TM, Ho PP, Sobel RA, Steinman L, Robinson WH. J Clin Immunol. 2011; 31 (6): 1010-20
• Tyrosine kinases in inflammatory dermatologic disease. Paniagua RT, Fiorentino DF, Chung L, Robinson WH. J Am Acad Dermatol. 2011; 65 (2): 389-403
• A model for harmonizing flow cytometry in clinical trials. Maecker HT, McCoy JP, Amos M, Elliott J, Gaigalas A, Wang L, Aranda R, Banchereau J, Boshoff C, Braun J, Korin Y, Reed E, Cho J, Hafler D, Davis M, Fathman CG, Robinson W, Denny T, Weinhold K, Desai B, Diamond B, Gregersen P, Di Meglio P, DiMeglio P, Nestle FO, Nestle F, Peakman M, Villanova F, Villnova F, Ferbas J, Field E, Kantor A, Kawabata T, Komocsar W, Lotze M, Nepom J, Ochs H, O'Lone R, Phippard D, Plevy S, Rich S, Roederer M, Rotrosen D, Yeh JH. Nat Immunol. 2010; 11 (11): 975-8
• A multitude of kinases--which are the best targets in treating rheumatoid arthritis? Lindstrom TM, Robinson WH. Rheum Dis Clin North Am. 2010; 36 (2): 367-83
• Autoimmunity against fibrinogen mediates inflammatory arthritis in mice. Ho PP, Lee LY, Zhao X, Tomooka BH, Paniagua RT, Sharpe O, BenBarak MJ, Chandra PE, Hueber W, Steinman L, Robinson WH. J Immunol. 2010; 184 (1): 379-90
• Biomarkers for rheumatoid arthritis: making it personal. Lindstrom TM, Robinson WH. Scand J Clin Lab Invest Suppl. 2010: 242 79-84
• Endogenous antibodies promote rapid myelin clearance and effective axon regeneration after nerve injury. Vargas ME, Watanabe J, Singh SJ, Robinson WH, Barres BA. Proc Natl Acad Sci U S A. 2010; 107 (26): 11993-8
• Natural killer cells trigger osteoclastogenesis and bone destruction in arthritis. Söderström K, Stein E, Colmenero P, Purath U, Müller-Ladner U, de Matos CT, Tarner IH, Robinson WH, Engleman EG. Proc Natl Acad Sci U S A. 2010; 107 (29): 13028-33
• Rheumatoid arthritis: a role for immunosenescence? Lindstrom TM, Robinson WH. J Am Geriatr Soc. 2010; 58 (8): 1565-75
• c-Fms-mediated differentiation and priming of monocyte lineage cells play a central role in autoimmune arthritis. Paniagua RT, Chang A, Mariano MM, Stein EA, Wang Q, Lindstrom TM, Sharpe O, Roscow C, Ho PP, Lee DM, Robinson WH. Arthritis Res Ther. 2010; 12 (1): R32
• Autoimmune disease classification by inverse association with SNP alleles. Sirota M, Schaub MA, Batzoglou S, Robinson WH, Butte AJ. PLoS Genet. 2009; 5 (12): e1000792
• Engagement of CD81 induces ezrin tyrosine phosphorylation and its cellular redistribution with filamentous actin. Coffey GP, Rajapaksa R, Liu R, Sharpe O, Kuo CC, Krauss SW, Sagi Y, Davis RE, Staudt LM, Sharman JP, Robinson WH, Levy S. J Cell Sci. 2009; 122 (Pt 17): 3137-44
• Genomics and proteomics: Applications in autoimmune diseases. Hueber W, Robinson WH. Pharmgenomics Pers Med. 2009: 2 39-48
• Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease. Britschgi M, Olin CE, Johns HT, Takeda-Uchimura Y, LeMieux MC, Rufibach K, Rajadas J, Zhang H, Tomooka B, Robinson WH, Clark CM, Fagan AM, Galasko DR, Holtzman DM, Jutel M, Kaye JA, Lemere CA, Leszek J, Li G, Peskind ER, Quinn JF, Yesavage JA, Ghiso JA, Wyss-Coray T. Proc Natl Acad Sci U S A. 2009; 106 (29): 12145-50
• Thrombin-activatable carboxypeptidase B cleavage of osteopontin regulates neutrophil survival and synoviocyte binding in rheumatoid arthritis. Sharif SA, Du X, Myles T, Song JJ, Price E, Lee DM, Goodman SB, Nagashima M, Morser J, Robinson WH, Leung LL. Arthritis Rheum. 2009; 60 (10): 2902-12
• Epitope spreading to citrullinated antigens in mouse models of autoimmune arthritis and demyelination. Kidd BA, Ho PP, Sharpe O, Zhao X, Tomooka BH, Kanter JL, Steinman L, Robinson WH. Arthritis Res Ther. 2008; 10 (5): R119
• Genomic and proteomic analysis reveals a threshold level of MYC required for tumor maintenance. Shachaf CM, Gentles AJ, Elchuri S, Sahoo D, Soen Y, Sharpe O, Perez OD, Chang M, Mitchel D, Robinson WH, Dill D, Nolan GP, Plevritis SK, Felsher DW. Cancer Res. 2008; 68 (13): 5132-42
• Regulation of tissue inflammation by thrombin-activatable carboxypeptidase B (or TAFI). Leung LL, Myles T, Nishimura T, Song JJ, Robinson WH. Mol Immunol. 2008; 45 (16): 4080-3
• Identification of biomarkers associated with the development of hepatocellular carcinoma in CuZn superoxide dismutase deficient mice. Elchuri S, Naeemuddin M, Sharpe O, Robinson WH, Huang TT. Proteomics. 2007; 7 (12): 2121-9
• Imatinib for the treatment of rheumatic diseases. Paniagua RT, Robinson WH. Nat Clin Pract Rheumatol. 2007; 3 (4): 190-1
• Induction of antigen-specific tolerance in multiple sclerosis after immunization with DNA encoding myelin basic protein in a randomized, placebo-controlled phase 1/2 trial. Bar-Or A, Vollmer T, Antel J, Arnold DL, Bodner CA, Campagnolo D, Gianettoni J, Jalili F, Kachuck N, Lapierre Y, Niino M, Oger J, Price M, Rhodes S, Robinson WH, Shi FD, Utz PJ, Valone F, Weiner L, Steinman L, Garren H. Arch Neurol. 2007; 64 (10): 1407-15
• Protective and therapeutic role for alphaB-crystallin in autoimmune demyelination. Ousman SS, Tomooka BH, van Noort JM, Wawrousek EF, O'Connor KC, Hafler DA, Sobel RA, Robinson WH, Steinman L. Nature. 2007; 448 (7152): 474-9
• Proteomic analysis of secreted proteins in early rheumatoid arthritis: anti-citrulline autoreactivity is associated with up regulation of proinflammatory cytokines. Hueber W, Tomooka BH, Zhao X, Kidd BA, Drijfhout JW, Fries JF, van Venrooij WJ, Metzger AL, Genovese MC, Robinson WH. Ann Rheum Dis. 2007; 66 (6): 712-9
• Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. Kuhn KA, Kulik L, Tomooka B, Braschler KJ, Arend WP, Robinson WH, Holers VM. J Clin Invest. 2006; 116 (4): 961-73
• Antigen arrays for antibody profiling. Robinson WH, Curr Opin Chem Biol. 2006; 10 (1): 67-72
• Fluid supported lipid bilayers containing monosialoganglioside GM1: a QCM-D and FRAP study. Weng KC, Kanter JL, Robinson WH, Frank CW. Colloids Surf B Biointerfaces. 2006; 50 (1): 76-84
• Proteomic biomarkers for autoimmune disease. Hueber W, Robinson WH. Proteomics. 2006; 6 (14): 4100-5
• Tolerizing DNA vaccines for autoimmune arthritis. Ho PP, Higgins JP, Kidd BA, Tomooka B, Digennaro C, Lee LY, de Vegvar HE, Steinman L, Robinson WH. Autoimmunity. 2006; 39 (8): 675-82
• A suppressive oligodeoxynucleotide enhances the efficacy of myelin cocktail/IL-4-tolerizing DNA vaccination and treats autoimmune disease. Ho PP, Fontoura P, Platten M, Sobel RA, DeVoss JJ, Lee LY, Kidd BA, Tomooka BH, Capers J, Agrawal A, Gupta R, Zernik J, Yee MK, Lee BJ, Garren H, Robinson WH, Steinman L. J Immunol. 2005; 175 (9): 6226-34
• Antigen microarray profiling of autoantibodies in rheumatoid arthritis. Hueber W, Kidd BA, Tomooka BH, Lee BJ, Bruce B, Fries JF, Sønderstrup G, Monach P, Drijfhout JW, van Venrooij WJ, Utz PJ, Genovese MC, Robinson WH. Arthritis Rheum. 2005; 52 (9): 2645-55
• Suppression of autoimmunity via microbial mimics of altered peptide ligands. Steinman L, Utz PJ, Robinson WH. Curr Top Microbiol Immunol. 2005: 296 55-63
• Treatment of autoimmune neuroinflammation with a synthetic tryptophan metabolite. Platten M, Ho PP, Youssef S, Fontoura P, Garren H, Hur EM, Gupta R, Lee LY, Kidd BA, Robinson WH, Sobel RA, Selley ML, Steinman L. Science. 2005; 310 (5749): 850-5
• Characterization of novel antigens recognized by serum autoantibodies from anti-CD1 TCR-transgenic lupus mice. Hueber W, Zeng D, Sharpe O, Robinson WH, Strober S, Utz PJ. Eur J Immunol. 2004; 34 (6): 1654-62
• High-throughput methods for measuring autoantibodies in systemic lupus erythematosus and other autoimmune diseases. Graham KL, Robinson WH, Steinman L, Utz PJ. Autoimmunity. 2004; 37 (4): 269-72
• Immunity to the extracellular domain of Nogo-A modulates experimental autoimmune encephalomyelitis. Fontoura P, Ho PP, DeVoss J, Zheng B, Lee BJ, Kidd BA, Garren H, Sobel RA, Robinson WH, Tessier-Lavigne M, Steinman L. J Immunol. 2004; 173 (11): 6981-92
• Microarray profiling of antiviral antibodies for the development of diagnostics, vaccines, and therapeutics. Neuman de Vegvar HE, Robinson WH. Clin Immunol. 2004; 111 (2): 196-201
• Unlocking the "PAD" lock on rheumatoid arthritis. Utz PJ, Genovese MC, Robinson WH. Ann Rheum Dis. 2004; 63 (4): 330-2
• Autoantibodies in early arthritis: advances in diagnosis and prognostication. Hueber W, Utz PJ, Robinson WH. Clin Exp Rheumatol. 2003 Sep-Oct; 21 (5 Suppl 31): S59-64
• Genomic and proteomic analysis of multiple sclerosis. Opinion. Robinson WH, Utz PJ, Steinman L. Curr Opin Immunol. 2003; 15 (6): 660-7
• Microarray profiling of antibody responses against simian-human immunodeficiency virus: postchallenge convergence of reactivities independent of host histocompatibility type and vaccine regimen. Neuman de Vegvar HE, Amara RR, Steinman L, Utz PJ, Robinson HL, Robinson WH. J Virol. 2003; 77 (20): 11125-38
• Protein arrays for autoantibody profiling and fine-specificity mapping. Robinson WH, Steinman L, Utz PJ. Proteomics. 2003; 3 (11): 2077-84
• Protein microarrays guide tolerizing DNA vaccine treatment of autoimmune encephalomyelitis. Robinson WH, Fontoura P, Lee BJ, de Vegvar HE, Tom J, Pedotti R, DiGennaro CD, Mitchell DJ, Fong D, Ho PP, Ruiz PJ, Maverakis E, Stevens DB, Bernard CC, Martin R, Kuchroo VK, van Noort JM, Genain CP, Amor S, Olsson T, Utz PJ, Garren H, Steinman L. Nat Biotechnol. 2003; 21 (9): 1033-9
• Autoantibody profiling for the study and treatment of autoimmune disease. Hueber W, Utz PJ, Steinman L, Robinson WH. Arthritis Res. 2002; 4 (5): 290-5
• Autoantigen microarrays for multiplex characterization of autoantibody responses. Robinson WH, DiGennaro C, Hueber W, Haab BB, Kamachi M, Dean EJ, Fournel S, Fong D, Genovese MC, de Vegvar HE, Skriner K, Hirschberg DL, Morris RI, Muller S, Pruijn GJ, van Venrooij WJ, Smolen JS, Brown PO, Steinman L, Utz PJ. Nat Med. 2002; 8 (3): 295-301
• Millennium Award. Proteomics for the development of DNA tolerizing vaccines to treat autoimmune disease. Robinson WH, Garren H, Utz PJ, Steinman L. Clin Immunol. 2002; 103 (1): 7-12
• Protein and peptide array analysis of autoimmune disease. Robinson WH, Steinman L, Utz PJ. Biotechniques. 2002: Suppl 66-9
• Proteomics technologies for the study of autoimmune disease. Robinson WH, Steinman L, Utz PJ. Arthritis Rheum. 2002; 46 (4): 885-93
• Demyelinating and neurologic events reported in association with tumor necrosis factor alpha antagonism: by what mechanisms could tumor necrosis factor alpha antagonists improve rheumatoid arthritis but exacerbate multiple sclerosis? Robinson WH, Genovese MC, Moreland LW. Arthritis Rheum. 2001; 44 (9): 1977-83
• Allele-specific expression of the mouse B-cell surface protein CD72 on T cells. Robinson WH, Landolfi MM, Parnes JR. Immunogenetics. 1997; 45 (3): 195-200
• Human CD6 possesses a large, alternatively spliced cytoplasmic domain. Robinson WH, Neuman de Vegvar HE, Prohaska SS, Rhee JW, Parnes JR. Eur J Immunol. 1995; 25 (10): 2765-9
• Identification of a mouse protein homologous to the human CD6 T cell surface protein and sequence of the corresponding cDNA. Robinson WH, Prohaska SS, Santoro JC, Robinson HL, Parnes JR. J Immunol. 1995; 155 (10): 4739-48
• Structure of the mouse CD72 (Lyb-2) gene and its alternatively spliced transcripts. Ying H, Nakayama E, Robinson WH, Parnes JR. J Immunol. 1995; 154 (6): 2743-52
• Biochemical identity of the mouse Ly-19.2 and Ly-32.2 alloantigens with the B cell differentiation antigen Lyb-2/CD72. Robinson WH, Landolfi MM, Schäfer H, Parnes JR. J Immunol. 1993; 151 (9): 4764-72
• Extensive polymorphism in the extracellular domain of the mouse B cell differentiation antigen Lyb-2/CD72. Robinson WH, Ying H, Miceli MC, Parnes JR. J Immunol. 1992; 149 (3): 880-6
• Synthesis of viral-specific ribonucleic Acid in rubella virus-infected cells. Wong KT, Robinson WS, Merigan TC. J Virol. 1969; 4 (6): 901-3