Paul A. Khavari, MD, PhD

Publications

• ACTL6a enforces the epidermal progenitor state by suppressing SWI/SNF-dependent induction of KLF4. Bao X, Tang J, Lopez-Pajares V, Tao S, Qu K, Crabtree GR, Khavari PA. Cell Stem Cell. 2013; 12 (2): 193-203
• Control of somatic tissue differentiation by the long non-coding RNA TINCR. Kretz M, Siprashvili Z, Chu C, Webster DE, Zehnder A, Qu K, Lee CS, Flockhart RJ, Groff AF, Chow J, Johnston D, Kim GE, Spitale RC, Flynn RA, Zheng GX, Aiyer S, Raj A, Rinn JL, Chang HY, Khavari PA. Nature. 2013; 493 (7431): 231-5
• IQGAP1 scaffold-kinase interaction blockade selectively targets RAS-MAP kinase-driven tumors. Jameson KL, Mazur PK, Zehnder AM, Zhang J, Zarnegar B, Sage J, Khavari PA. Nat Med. 2013; 19 (5): 626-30
• ZNF750 is a p63 target gene that induces KLF4 to drive terminal epidermal differentiation. Sen GL, Boxer LD, Webster DE, Bussat RT, Qu K, Zarnegar BJ, Johnston D, Siprashvili Z, Khavari PA. Dev Cell. 2012; 22 (3): 669-77
• DNMT1 maintains progenitor function in self-renewing somatic tissue. Sen GL, Reuter JA, Webster DE, Zhu L, Khavari PA. Nature. 2010; 463 (7280): 563-7
• Invasive three-dimensional organotypic neoplasia from multiple normal human epithelia Ridky TW, Khavari PA. Nature Medicine. 2010: 16 1450-1455
• Modeling inducible human tissue neoplasia identifies an extracellular matrix interaction network involved in cancer progression. Reuter JA, Ortiz-Urda S, Kretz M, Garcia J, Scholl FA, Pasmooij AM, Cassarino D, Chang HY, Khavari PA. Cancer Cell. 2009; 15 (6): 477-88
• Type VII collagen is required for Ras-driven human epidermal tumorigenesis. Ortiz-Urda S, Garcia J, Green CL, Chen L, Lin Q, Veitch DP, Sakai LY, Lee H, Marinkovich MP, Khavari PA. Science. 2005; 307 (5716): 1773-6
• Use of human tissue to assess the oncogenic activity of melanoma-associated mutations. Chudnovsky Y, Adams AE, Robbins PB, Lin Q, Khavari PA. Nat Genet. 2005; 37 (7): 745-9
• NF-kappaB blockade and oncogenic Ras trigger invasive human epidermal neoplasia. Dajee M, Lazarov M, Zhang JY, Cai T, Green CL, Russell AJ, Marinkovich MP, Tao S, Lin Q, Kubo Y, Khavari PA. Nature. 2003; 421 (6923): 639-43
• CDK4 coexpression with Ras generates malignant human epidermal tumorigenesis. Lazarov M, Kubo Y, Cai T, Dajee M, Tarutani M, Lin Q, Fang M, Tao S, Green CL, Khavari PA. Nat Med. 2002; 8 (10): 1105-14
• Stable nonviral genetic correction of inherited human skin disease Ortiz-Urda S, Thyagarajan B, Keene DR, Lin Q, Fang M, Calos MP, Khavari PA. Nature Medicine. 2002: 8 1166-1170
• Stable nonviral genetic correction of inherited human skin disease. Ortiz-Urda S, Thyagarajan B, Keene DR, Lin Q, Fang M, Calos MP, Khavari PA. Nat Med. 2002; 8 (10): 1166-70
• Conjugation of arginine oligomers to cyclosporin A facilitates topical delivery and inhibition of inflammation. Rothbard JB, Garlington S, Lin Q, Kirschberg T, Kreider E, McGrane PL, Wender PA, Khavari PA. Nat Med. 2000; 6 (11): 1253-7
• Immunization via hair follicles by topical application of naked DNA to normal skin. Fan H, Lin Q, Morrissey GR, Khavari PA. Nat Biotechnol. 1999; 17 (9): 870-2
• Gene therapy: progress, problems, prospects. Blau H, Khavari P. Nat Med. 1997; 3 (6): 612-3
• Induction of basal cell carcinoma features in transgenic human skin expressing Sonic Hedgehog. Fan H, Oro AE, Scott MP, Khavari PA. Nat Med. 1997; 3 (7): 788-92
• Sustainable cutaneous gene delivery. Deng H, Lin Q, Khavari PA. Nat Biotechnol. 1997; 15 (13): 1388-91
• Corrective gene transfer in the human skin disorder lamellar ichthyosis. Choate KA, Medalie DA, Morgan JR, Khavari PA. Nat Med. 1996; 2 (11): 1263-7
• Nucleosome disruption and enhancement of activator binding by a human SW1/SNF complex. Kwon H, Imbalzano AN, Khavari PA, Kingston RE, Green MR. Nature. 1994; 370 (6489): 477-81
• The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Dunaief JL, Strober BE, Guha S, Khavari PA, Alin K, Luban J, Begemann M, Crabtree GR, Goff SP. Cell. 1994; 79 (1): 119-30
• BRG1 contains a conserved domain of the SWI2/SNF2 family necessary for normal mitotic growth and transcription. Khavari PA, Peterson CL, Tamkun JW, Mendel DB, Crabtree GR. Nature. 1993; 366 (6451): 170-4
• Characterization of a cofactor that regulates dimerization of a mammalian homeodomain protein. Mendel DB, Khavari PA, Conley PB, Graves MK, Hansen LP, Admon A, Crabtree GR. Science. 1991; 254 (5039): 1762-7