Timothy Angelotti MD, PhD

Publications

• Systematic and quantitative analysis of G protein-coupled receptor trafficking motifs. Hurt CM, Ho VK, Angelotti T. Methods Enzymol. 2013: 521 171-87
• Regulation of G-protein coupled receptor traffic by an evolutionary conserved hydrophobic signal. Angelotti T, Daunt D, Shcherbakova OG, Kobilka B, Hurt CM. Traffic. 2010; 11 (4): 560-78
• Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalization. Lu R, Li Y, Zhang Y, Chen Y, Shields AD, Winder DG, Angelotti T, Jiao K, Limbird LE, Zhou Y, Wang Q. J Biol Chem. 2009; 284 (19): 13233-43
• Sex-specific modulation of spinal nociception by alpha2-adrenoceptors: differential regulation by estrogen and testosterone. Thompson AD, Angelotti T, Nag S, Mokha SS. Neuroscience. 2008; 153 (4): 1268-77
• Anesthetic implications of a near-lethal sodium azide exposure. Angelotti T, Mireles S, McMahon D. Anesth Analg. 2007; 104 (1): 229-30
• Molecular insights into alpha2 adrenergic receptor function: Clinical implications Hurt CM, Angelotti T. Seminars in Anesthesia, Perioperative Medicine and Pain. 2007; 26 (1): 28-34
• New methods for direct verification of correct endotracheal tube placement. Angelotti T, Brock-Utne J. Anesth Analg. 2007; 105 (4): 1168; author reply 1169
• Pharmacology and mechanism of action of pregabalin: the calcium channel alpha2-delta (alpha2-delta) subunit as a target for antiepileptic drug discovery. Taylor CP, Angelotti T, Fauman E. Epilepsy Res. 2007; 73 (2): 137-50
• Verification of endotracheal tube placement by prehospital providers: is a portable fiberoptic bronchoscope of value? Angelotti T, Weiss EL, Lemmens HJ, Brock-Utne J. Air Med J. 2006 Mar-Apr; 25 (2): 74-8; discussion 78-80
• Differential targeting and function of alpha2A and alpha2C adrenergic receptor subtypes in cultured sympathetic neurons. Brum PC, Hurt CM, Shcherbakova OG, Kobilka B, Angelotti T. Neuropharmacology. 2006; 51 (3): 397-413
• Anesthesia for older patients with hypertrophic cardiomyopathy: Is there cause for concern? Angelotti T, Fuller A, Rivera L, Schmiesing C. J Clin Anesth. 2005; 17 (6): 478-81
• Alpha2A and alpha2C adrenoceptors undergo agonist stimulated internalization when expressed in neurons: Role of cell type in signaling and trafficking of G-protein coupled receptors. Angelotti T, Hurt CM, Brum PC, Lee TW, Feng FY, Kobilka B.. Mol Pharm (in preparation).. 2004
• Diagnosis of an unsuspected maternal hemorrhage via fetal heart rate tracing. Doyle C, Angelotti T. J Clin Anesth. 2004; 16 (6): 465-8
• Right subclavian artery injury. Angelotti T, Amador ER. Anesth Analg. 2003; 96 (4): 1237
• Nodular invasive tracheobronchitis due to Aspergillus in a patient with systemic lupus erythematosus. Angelotti T, Krishna G, Scott J, Berry G, Weinacker A. Lupus. 2002; 11 (5): 325-8
• Activation of phosphatidylinositol 3-kinase is necessary for differentiation of FDC-P1 cells following stimulation of type III receptor tyrosine kinases. Kubota Y, Angelotti T, Niederfellner G, Herbst R, Ullrich A. Cell Growth Differ. 1998; 9 (3): 247-56
• The "VH1-like" dual-specificity protein tyrosine phosphatases. Martell KJ, Angelotti T, Ullrich A. Mol Cells. 1998; 8 (1): 2-11
• Enhancement of recombinant alpha 1 beta 1 gamma 2L gamma-aminobutyric acidA receptor whole-cell currents by protein kinase C is mediated through phosphorylation of both beta 1 and gamma 2L subunits. Lin YF, Angelotti TP, Dudek EM, Browning MD, Macdonald RL. Mol Pharmacol. 1996; 50 (1): 185-95
• Functional expression of recombinant GABAA receptor channels in L929 fibroblasts. Macdonald RL, Saxena NC, Angelotti TP. Epilepsy Res Suppl. 1996: 12 177-85
• Tissue-specific expression of splice variants of the mouse voltage-gated calcium channel alpha2/delta subunit. Angelotti T, Hofmann F. FEBS Lett. 1996; 397 (2-3): 331-7
• The type II isoform of cGMP-dependent protein kinase is dimeric and possesses regulatory and catalytic properties distinct from the type I isoforms. Gamm DM, Francis SH, Angelotti TP, Corbin JD, Uhler MD. J Biol Chem. 1995; 270 (45): 27380-8
• Fluorescent b-galactosidase staining of transfected cells prior to patch clamp recording. Angelotti, TP, Macdonald RL. AxoBits. 1994; 15 (15): 6-8
• Assembly of GABAA receptor subunits: alpha 1 beta 1 and alpha 1 beta 1 gamma 2S subunits produce unique ion channels with dissimilar single-channel properties. Angelotti TP, Macdonald RL. J Neurosci. 1993; 13 (4): 1429-40
• Assembly of GABAA receptor subunits: analysis of transient single-cell expression utilizing a fluorescent substrate/marker gene technique. Angelotti TP, Uhler MD, Macdonald RL. J Neurosci. 1993; 13 (4): 1418-28
• Enhancement of recombinant gamma-aminobutyric acid type A receptor currents by chronic activation of cAMP-dependent protein kinase. Angelotti TP, Uhler MD, Macdonald RL. Mol Pharmacol. 1993; 44 (6): 1202-10
• Kinetic properties of alpha 1 beta 1 gamma-aminobutyric acidA receptor channels expressed in Chinese hamster ovary cells: regulation by pentobarbital and picrotoxin. Porter NM, Angelotti TP, Twyman RE, MacDonald RL. Mol Pharmacol. 1992; 42 (5): 872-81
• Molecular and electrophysiological characterization of a allelic variant of the rat alpha 6 GABAA receptor subunit. Angelotti TP, Tan F, Chahine KG, Macdonald RL. Brain Res Mol Brain Res. 1992; 16 (1-2): 173-8
• Regulation of GABAA receptor channels by anticonvulsant and convulsant drugs and by phosphorylation. Macdonald RL, Twyman RE, Ryan-Jastrow T, Angelotti TP. Epilepsy Res Suppl. 1992: 9 265-77
• Biotinylated granulocyte/macrophage colony-stimulating factor analogues: effect of linkage chemistry on activity and binding. Angelotti TP, Clarke MF, Longino MA, Emerson SG. Bioconjug Chem. 1991 Nov-Dec; 2 (6): 466-74