Gilbert Chu

Publications

• Cooperative assembly of a protein-DNA filament for nonhomologous end joining. Tsai CJ, Chu G. J Biol Chem. 2013
• Local false discovery rate facilitates comparison of different microarray experiments. Hong WJ, Tibshirani R, Chu G. Nucleic Acids Res. 2009; 37 (22): 7483-97
• Here comes the sun: recognition of UV-damaged DNA. Chu G, Yang W. Cell. 2008; 135 (7): 1172-4
• Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends. Tsai CJ, Kim SA, Chu G. Proc Natl Acad Sci U S A. 2007; 104 (19): 7851-6
• Processing of DNA for nonhomologous end-joining is controlled by kinase activity and XRCC4/ligase IV. Budman J, Kim SA, Chu G. J Biol Chem. 2007; 282 (16): 11950-9
• Processing of DNA for nonhomologous end-joining by cell-free extract. Budman J, Chu G. EMBO J. 2005; 24 (4): 849-60
• Toxicity from radiation therapy associated with abnormal transcriptional responses to DNA damage. Rieger KE, Hong WJ, Tusher VG, Tang J, Tibshirani R, Chu G. Proc Natl Acad Sci U S A. 2004; 101 (17): 6635-40
• Significance analysis of microarrays applied to the ionizing radiation response. Tusher VG, Tibshirani R, Chu G. Proc Natl Acad Sci U S A. 2001; 98 (9): 5116-21
• Electrophoretic mobility shift assays for protein-DNA complexes involved in DNA repair. Tsai C, Smider V, Hwang BJ, Chu G. Methods Mol Biol. 2012: 920 53-78
• An information theoretic, microfluidic-based single cell analysis permits identification of subpopulations among putatively homogeneous stem cells. Glotzbach JP, Januszyk M, Vial IN, Wong VW, Gelbard A, Kalisky T, Thangarajah H, Longaker MT, Quake SR, Chu G, Gurtner GC. PLoS One. 2011; 6 (6): e21211
• Assays for nonhomologous end joining in extracts. Budman J, Chu G. Methods Enzymol. 2006: 408 430-44
• Portrait of transcriptional responses to ultraviolet and ionizing radiation in human cells. Rieger KE, Chu G. Nucleic Acids Res. 2004; 32 (16): 4786-803
• Diagnosis of multiple cancer types by shrunken centroids of gene expression. Tibshirani R, Hastie T, Narasimhan B, Chu G. Proc Natl Acad Sci U S A. 2002; 99 (10): 6567-72
• Synapsis of DNA ends by DNA-dependent protein kinase. DeFazio LG, Stansel RM, Griffith JD, Chu G. EMBO J. 2002; 21 (12): 3192-200
• Xeroderma pigmentosum complementation group E and UV-damaged DNA-binding protein. Tang J, Chu G. DNA Repair (Amst). 2002; 1 (8): 601-16
• p53 Binds and activates the xeroderma pigmentosum DDB2 gene in humans but not mice. Tan T, Chu G. Mol Cell Biol. 2002; 22 (10): 3247-54
• Activation of DNA-dependent protein kinase by single-stranded DNA ends. Hammarsten O, DeFazio LG, Chu G. J Biol Chem. 2000; 275 (3): 1541-50
• Xeroderma pigmentosum p48 gene enhances global genomic repair and suppresses UV-induced mutagenesis. Tang JY, Hwang BJ, Ford JM, Hanawalt PC, Chu G. Mol Cell. 2000; 5 (4): 737-44
• Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair. Hwang BJ, Ford JM, Hanawalt PC, Chu G. Proc Natl Acad Sci U S A. 1999; 96 (2): 424-8
• Structure of DNA-dependent protein kinase: implications for its regulation by DNA. Leuther KK, Hammarsten O, Kornberg RD, Chu G. EMBO J. 1999; 18 (5): 1114-23
• The use of electrophoretic mobility shift assays to study DNA repair. Hwang BJ, Smider V, Chu G. Methods Mol Biol. 1999: 113 103-20
• DNA-dependent protein kinase: DNA binding and activation in the absence of Ku. Hammarsten O, Chu G. Proc Natl Acad Sci U S A. 1998; 95 (2): 525-30
• Failure of hairpin-ended and nicked DNA To activate DNA-dependent protein kinase: implications for V(D)J recombination. Smider V, Rathmell WK, Brown G, Lewis S, Chu G. Mol Cell Biol. 1998; 18 (11): 6853-8
• p48 Activates a UV-damaged-DNA binding factor and is defective in xeroderma pigmentosum group E cells that lack binding activity. Hwang BJ, Toering S, Francke U, Chu G. Mol Cell Biol. 1998; 18 (7): 4391-9
• DNA-dependent protein kinase is not required for accumulation of p53 or cell cycle arrest after DNA damage. Rathmell WK, Kaufmann WK, Hurt JC, Byrd LL, Chu G. Cancer Res. 1997; 57 (1): 68-74
• Double strand break repair. Chu G, J Biol Chem. 1997; 272 (39): 24097-100
• The end-joining reaction in V(D)J recombination. Smider V, Chu G. Semin Immunol. 1997; 9 (3): 189-97
• Isolation of a cDNA encoding a UV-damaged DNA binding factor defective in xeroderma pigmentosum group E cells. Hwang BJ, Liao JC, Chu G. Mutat Res. 1996; 362 (1): 105-17
• Role of the Ku autoantigen in V(D)J recombination and double-strand break repair. Chu G, Curr Top Microbiol Immunol. 1996: 217 113-32
• Xeroderma pigmentosum, Cockayne syndrome and trichothiodystrophy: do the genes explain the diseases? Chu G, Mayne L. Trends Genet. 1996; 12 (5): 187-92
• A DNA end-binding factor involved in double-strand break repair and V(D)J recombination. Rathmell WK, Chu G. Mol Cell Biol. 1994; 14 (7): 4741-8
• A novel role for DNA photolyase: binding to DNA damaged by drugs is associated with enhanced cytotoxicity in Saccharomyces cerevisiae. Fox ME, Feldman BJ, Chu G. Mol Cell Biol. 1994; 14 (12): 8071-7
• Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair. Chu G, J Biol Chem. 1994; 269 (2): 787-90
• Involvement of the Ku autoantigen in the cellular response to DNA double-strand breaks. Rathmell WK, Chu G. Proc Natl Acad Sci U S A. 1994; 91 (16): 7623-7
• Restoration of X-ray resistance and V(D)J recombination in mutant cells by Ku cDNA. Smider V, Rathmell WK, Lieber MR, Chu G. Science. 1994; 266 (5183): 288-91
• Xeroderma pigmentosum group E binding factor recognizes a broad spectrum of DNA damage. Payne A, Chu G. Mutat Res. 1994; 310 (1): 89-102
• Massive cisplatin overdose by accidental substitution for carboplatin. Toxicity and management. Chu G, Mantin R, Shen YM, Baskett G, Sussman H. Cancer. 1993; 72 (12): 3707-14
• Purification and characterization of a human protein that binds to damaged DNA. Hwang BJ, Chu G. Biochemistry. 1993; 32 (6): 1657-66
• Bag model for DNA migration during pulsed-field electrophoresis. Chu G, Proc Natl Acad Sci U S A. 1991; 88 (24): 11071-5
• Pulsed-field electrophoresis of megabase-sized DNA. Gunderson K, Chu G. Mol Cell Biol. 1991; 11 (6): 3348-54
• Separation of large DNA by a variable-angle contour-clamped homogeneous electric field apparatus. Chu G, Gunderson K. Anal Biochem. 1991; 194 (2): 439-46
• Cisplatin-resistant cells express increased levels of a factor that recognizes damaged DNA. Chu G, Chang E. Proc Natl Acad Sci U S A. 1990; 87 (9): 3324-7
• Xeroderma pigmentosum group E cells lack a nuclear factor that binds to damaged DNA. Chu G, Chang E. Science. 1988; 242 (4878): 564-7