John Cooke, MD, PhD

Publications

• Therapeutic transdifferentiation: a novel approach for vascular disease. Cooke JP, Circ Res. 2013; 112 (5): 748-50
• Activation of innate immunity is required for efficient nuclear reprogramming. Lee J, Sayed N, Hunter A, Au KF, Wong WH, Mocarski ES, Pera RR, Yakubov E, Cooke JP. Cell. 2012; 151 (3): 547-58
• Endothelial cells derived from nuclear reprogramming. Wong WT, Huang NF, Botham CM, Sayed N, Cooke JP. Circ Res. 2012; 111 (10): 1363-75
• Multifunctional in vivo vascular imaging using near-infrared II fluorescence. Hong G, Lee JC, Robinson JT, Raaz U, Xie L, Huang NF, Cooke JP, Dai H. Nat Med. 2012; 18 (12): 1841-6
• DDAH says NO to ADMA. Cooke JP, Ghebremariam YT. Arterioscler Thromb Vasc Biol. 2011; 31 (7): 1462-4
• Dietary nitrate, nitric oxide, and restenosis. Cooke JP, Ghebremariam YT. J Clin Invest. 2011; 121 (4): 1258-60
• Endothelial cells derived from human iPSCS increase capillary density and improve perfusion in a mouse model of peripheral arterial disease. Rufaihah AJ, Huang NF, Jamé S, Lee JC, Nguyen HN, Byers B, De A, Okogbaa J, Rollins M, Reijo-Pera R, Gambhir SS, Cooke JP. Arterioscler Thromb Vasc Biol. 2011; 31 (11): e72-9
• MicroRNA and mechanisms of impaired angiogenesis in diabetes mellitus. Leeper NJ, Cooke JP. Circulation. 2011; 123 (3): 236-8
• Embryonic stem cell-derived endothelial cells engraft into the ischemic hindlimb and restore perfusion. Huang NF, Niiyama H, Peter C, De A, Natkunam Y, Fleissner F, Li Z, Rollins MD, Wu JC, Gambhir SS, Cooke JP. Arterioscler Thromb Vasc Biol. 2010; 30 (5): 984-91
• Role of nitric oxide signaling in endothelial differentiation of embryonic stem cells. Huang NF, Fleissner F, Sun J, Cooke JP. Stem Cells Dev. 2010; 19 (10): 1617-26
• Cholinergic modulation of angiogenesis: role of the 7 nicotinic acetylcholine receptor. Wu JC, Chruscinski A, De Jesus Perez VA, Singh H, Pitsiouni M, Rabinovitch M, Utz PJ, Cooke JP. J Cell Biochem. 2009; 108 (2): 433-46
• Embryonic stem cell-derived endothelial cells for treatment of hindlimb ischemia. Huang NF, Niiyama H, De A, Gambhir SS, Cooke JP. J Vis Exp. 2009; (23)
• Dimethylarginine dimethylaminohydrolase overexpression enhances insulin sensitivity. Sydow K, Mondon CE, Schrader J, Konishi H, Cooke JP. Arterioscler Thromb Vasc Biol. 2008; 28 (4): 692-7
• A central role for nicotinic cholinergic regulation of growth factor-induced endothelial cell migration. Ng MK, Wu J, Chang E, Wang BY, Katzenberg-Clark R, Ishii-Watabe A, Cooke JP. Arterioscler Thromb Vasc Biol. 2007; 27 (1): 106-12
• Dimethylarginine dimethylaminohydrolase overexpression suppresses graft coronary artery disease. Tanaka M, Sydow K, Gunawan F, Jacobi J, Tsao PS, Robbins RC, Cooke JP. Circulation. 2005; 112 (11): 1549-56
• Overexpression of dimethylarginine dimethylaminohydrolase reduces tissue asymmetric dimethylarginine levels and enhances angiogenesis. Jacobi J, Sydow K, von Degenfeld G, Zhang Y, Dayoub H, Wang B, Patterson AJ, Kimoto M, Blau HM, Cooke JP. Circulation. 2005; 111 (11): 1431-8
• Asymmetrical dimethylarginine: the Uber marker? Cooke JP, Circulation. 2004; 109 (15): 1813-8
• Dimethylarginine dimethylaminohydrolase regulates nitric oxide synthesis: genetic and physiological evidence. Dayoub H, Achan V, Adimoolam S, Jacobi J, Stuehlinger MC, Wang BY, Tsao PS, Kimoto M, Vallance P, Patterson AJ, Cooke JP. Circulation. 2003; 108 (24): 3042-7
• Second hand smoke stimulates tumor angiogenesis and growth. Zhu BQ, Heeschen C, Sievers RE, Karliner JS, Parmley WW, Glantz SA, Cooke JP. Cancer Cell. 2003; 4 (3): 191-6
• A novel angiogenic pathway mediated by non-neuronal nicotinic acetylcholine receptors. Heeschen C, Weis M, Aicher A, Dimmeler S, Cooke JP. J Clin Invest. 2002; 110 (4): 527-36
• Impaired nitric oxide synthase pathway in diabetes mellitus: role of asymmetric dimethylarginine and dimethylarginine dimethylaminohydrolase. Lin KY, Ito A, Asagami T, Tsao PS, Adimoolam S, Kimoto M, Tsuji H, Reaven GM, Cooke JP. Circulation. 2002; 106 (8): 987-92
• Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Heeschen C, Jang JJ, Weis M, Pathak A, Kaji S, Hu RS, Tsao PS, Johnson FL, Cooke JP. Nat Med. 2001; 7 (7): 833-9
• Alternative ankle-brachial index method identifies additional at-risk individuals. Nead KT, Cooke JP, Olin JW, Leeper NJ. J Am Coll Cardiol. 2013
• Exercise capacity is the strongest predictor of mortality in patients with peripheral arterial disease. Leeper NJ, Myers J, Zhou M, Nead KT, Syed A, Kojima Y, Caceres RD, Cooke JP. J Vasc Surg. 2013; 57 (3): 728-33
• FXR agonist INT-747 upregulates DDAH expression and enhances insulin sensitivity in high-salt fed Dahl rats. Ghebremariam YT, Yamada K, Lee JC, Johnson CL, Atzler D, Anderssohn M, Agrawal R, Higgins JP, Patterson AJ, Böger RH, Cooke JP. PLoS One. 2013; 8 (4): e60653
• Human induced pluripotent stem cell-derived endothelial cells exhibit functional heterogeneity. Rufaihah AJ, Huang NF, Kim J, Herold J, Volz KS, Park TS, Lee JC, Zambidis ET, Reijo-Pera R, Cooke JP. Am J Transl Res. 2013; 5 (1): 21-35
• Limited gene expression variation in human embryonic stem cell and induced pluripotent stem cell-derived endothelial cells. White MP, Rufaihah AJ, Liu L, Ghebremariam YT, Ivey KN, Cooke JP, Srivastava D. Stem Cells. 2013; 31 (1): 92-103
• Spatial patterning of endothelium modulates cell morphology, adhesiveness and transcriptional signature. Huang NF, Lai ES, Ribeiro AJ, Pan S, Pruitt BL, Fuller GG, Cooke JP. Biomaterials. 2013; 34 (12): 2928-37
• The modulation of endothelial cell morphology, function, and survival using anisotropic nanofibrillar collagen scaffolds. Huang NF, Okogbaa J, Lee JC, Jha A, Zaitseva TS, Paukshto MV, Sun JS, Punjya N, Fuller GG, Cooke JP. Biomaterials. 2013; 34 (16): 4038-47
• The role of dimethylarginine dimethylaminohydrolase (DDAH) in pulmonary fibrosis. Janssen W, Pullamsetti SS, Cooke J, Weissmann N, Guenther A, Schermuly RT. J Pathol. 2013; 229 (2): 242-9
• Usefulness of the addition of beta-2-microglobulin, cystatin C and C-reactive protein to an established risk factors model to improve mortality risk prediction in patients undergoing coronary angiography. Nead KT, Zhou MJ, Caceres RD, Sharp SJ, Wehner MR, Olin JW, Cooke JP, Leeper NJ. Am J Cardiol. 2013; 111 (6): 851-6
• Walking impairment questionnaire improves mortality risk prediction models in a high-risk cohort independent of peripheral arterial disease status. Nead KT, Zhou M, Caceres RD, Olin JW, Cooke JP, Leeper NJ. Circ Cardiovasc Qual Outcomes. 2013; 6 (3): 255-61
• Development of pluripotent stem cells for vascular therapy. Volz KS, Miljan E, Khoo A, Cooke JP. Vascul Pharmacol. 2012 May-Jun; 56 (5-6): 288-96
• A validated biomarker panel to identify peripheral artery disease. Hiatt WR, Zakharyan A, Fung ET, Crutcher G, Smith A, Stanford C, Cooke J. Vasc Med. 2012; 17 (6): 386-93
• Aligned nanofibrillar collagen regulates endothelial organization and migration. Lai ES, Huang NF, Cooke JP, Fuller GG. Regen Med. 2012; 7 (5): 649-61
• Bioluminescence imaging of stem cell-based therapeutics for vascular regeneration. Huang NF, Okogbaa J, Babakhanyan A, Cooke JP. Theranostics. 2012; 2 (4): 346-54
• Development of a dimethylarginine dimethylaminohydrolase (DDAH) assay for high-throughput chemical screening. Ghebremariam YT, Erlanson DA, Yamada K, Cooke JP. J Biomol Screen. 2012; 17 (5): 651-61
• Endovascular correction of cerebrovenous anomalies in multiple sclerosis: a retrospective review of an uncontrolled case series. Dake MD, Dantzker N, Bennett WL, Cooke JP. Vasc Med. 2012; 17 (3): 131-7
• Genetic determinants of the ankle-brachial index: a meta-analysis of a cardiovascular candidate gene 50K SNP panel in the candidate gene association resource (CARe) consortium. Wassel CL, Lamina C, Nambi V, Coassin S, Mukamal KJ, Ganesh SK, Jacobs DR, Franceschini N, Papanicolaou GJ, Gibson Q, Yanek LR, van der Harst P, Ferguson JF, Crawford DC, Waite LL, Allison MA, Criqui MH, McDermott MM, Mehra R, Cupples LA, Hwang SJ, Redline S, Kaplan RC, Heiss G, Rotter JI, Boerwinkle E, Taylor HA, Eraso LH, Haun M, Li M, Meisinger C, O'Connell JR, Shuldiner AR, Tybjærg-Hansen A, Frikke-Schmidt R, Kollerits B, Rantner B, Dieplinger B, Stadler M, Mueller T, Haltmayer M, Klein-Weigel P, Summerer M, Wichmann HE, Asselbergs FW, Navis G, Mateo Leach I, Brown-Gentry K, Goodloe R, Assimes TL, Becker DM, Cooke JP, Absher DM, Olin JW, Mitchell BD, Reilly MP, Mohler ER, North KE, Reiner AP, Kronenberg F, Murabito JM. Atherosclerosis. 2012; 222 (1): 138-47
• Genetics of peripheral artery disease. Leeper NJ, Kullo IJ, Cooke JP. Circulation. 2012; 125 (25): 3220-8
• Imaging vascular nicotine receptors: a new window onto vascular disease. Cooke JP, JACC Cardiovasc Imaging. 2012; 5 (5): 537-9
• In Memoriam of John T. Shepherd, MD, DSc. Vanhoutte PM, Cooke JP, Cohen RA. Circulation. 2012; 125 (2): 393-4
• Lymphangiogenesis: a potential new therapy for lymphedema? Cooke JP, Circulation. 2012; 125 (7): 853-5
• Nicotine and pathological angiogenesis. Lee J, Cooke JP. Life Sci. 2012; 91 (21-22): 1058-64
• Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats. Tian XY, Wong WT, Leung FP, Zhang Y, Wang YX, Lee HK, Ng CF, Chen ZY, Yao X, Au CL, Lau CW, Vanhoutte PM, Cooke JP, Huang Y. Antioxid Redox Signal. 2012; 16 (4): 363-73
• PPARδ activation protects endothelial function in diabetic mice. Tian XY, Wong WT, Wang N, Lu Y, Cheang WS, Liu J, Liu L, Liu Y, Lee SS, Chen ZY, Cooke JP, Yao X, Huang Y. Diabetes. 2012; 61 (12): 3285-93
• Identification and classification of acute cardiac rejection by intragraft transcriptional profiling. Holweg CT, Potena L, Luikart H, Yu T, Berry GJ, Cooke JP, Valantine HA, Mocarski ES. Circulation. 2011; 123 (20): 2236-43
• Increased nitric oxide availability attenuates high fat diet metabolic alterations and gene expression associated with insulin resistance. Razny U, Kiec-Wilk B, Wator L, Polus A, Dyduch G, Solnica B, Malecki M, Tomaszewska R, Cooke JP, Dembinska-Kiec A. Cardiovasc Diabetol. 2011: 10 68
• Low lifetime recreational activity is a risk factor for peripheral arterial disease. Wilson AM, Sadrzadeh-Rafie AH, Myers J, Assimes T, Nead KT, Higgins M, Gabriel A, Olin J, Cooke JP. J Vasc Surg. 2011; 54 (2): 427-32, 432.e1-4
• Meal-induced increases in C-reactive protein, interleukin-6 and tumour necrosis factor α are attenuated by prandial + basal insulin in patients with Type 2 diabetes. Beisswenger PJ, Brown WV, Ceriello A, Le NA, Goldberg RB, Cooke JP, Robbins DC, Sarwat S, Yuan H, Jones CA, Tan MH. Diabet Med. 2011; 28 (9): 1088-95
• Solubility partner IF2 Domain I enables high yield synthesis of transducible transcription factors in Escherichia coli. Yang WC, Welsh JP, Lee J, Cooke JP, Swartz JR. Protein Expr Purif. 2011; 80 (1): 145-51
• The role of nicotine in the pathogenesis of atherosclerosis. Lee J, Cooke JP. Atherosclerosis. 2011; 215 (2): 281-3
• Two decades of progress in vascular medicine. Leeper NJ, Lee JT, Cooke JP. Am J Med. 2011; 124 (9): 791-2
• A matrix micropatterning platform for cell localization and stem cell fate determination. Huang NF, Patlolla B, Abilez O, Sharma H, Rajadas J, Beygui RE, Zarins CK, Cooke JP. Acta Biomater. 2010; 6 (12): 4614-21
• Assessing endothelial vasodilator function with the Endo-PAT 2000. Axtell AL, Gomari FA, Cooke JP. J Vis Exp. 2010; (44)
• Asymmetric dimethylarginine correlates with measures of disease severity, major adverse cardiovascular events and all-cause mortality in patients with peripheral arterial disease. Wilson AM, Shin DS, Weatherby C, Harada RK, Ng MK, Nair N, Kielstein J, Cooke JP. Vasc Med. 2010; 15 (4): 267-74
• Biomarkers of peripheral arterial disease. Cooke JP, Wilson AM. J Am Coll Cardiol. 2010; 55 (19): 2017-23
• Cholinergic activation of hematopoietic stem cells: role in tobacco-related disease? Chang E, Forsberg EC, Wu J, Bingyin Wang, Prohaska SS, Allsopp R, Weissman IL, Cooke JP. Vasc Med. 2010; 15 (5): 375-85
• Chronic exposure to nicotine impairs cholinergic angiogenesis. Konishi H, Wu J, Cooke JP. Vasc Med. 2010; 15 (1): 47-54
• DDAH: a target for vascular therapy? Cooke JP, Vasc Med. 2010; 15 (3): 235-8
• Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. Rodionov RN, Dayoub H, Lynch CM, Wilson KM, Stevens JW, Murry DJ, Kimoto M, Arning E, Bottiglieri T, Cooke JP, Baumbach GL, Faraci FM, Lentz SR. Circ Res. 2010; 106 (3): 551-8
• Relationship of asymmetric dimethylarginine and homocysteine to vascular aging in systemic lupus erythematosus patients. Perna M, Roman MJ, Alpert DR, Crow MK, Lockshin MD, Sammaritano L, Devereux RB, Cooke JP, Salmon JE. Arthritis Rheum. 2010; 62 (6): 1718-22
• Sex differences in the prevalence of peripheral artery disease in patients undergoing coronary catheterization. Sadrzadeh Rafie AH, Stefanick ML, Sims ST, Phan T, Higgins M, Gabriel A, Assimes T, Narasimhan B, Nead KT, Myers J, Olin J, Cooke JP. Vasc Med. 2010; 15 (6): 443-50
• Stem cell therapy for vascular regeneration: adult, embryonic, and induced pluripotent stem cells. Leeper NJ, Hunter AL, Cooke JP. Circulation. 2010; 122 (5): 517-26
• The emerging role of the thioredoxin system in angiogenesis. Dunn LL, Buckle AM, Cooke JP, Ng MK. Arterioscler Thromb Vasc Biol. 2010; 30 (11): 2089-98
• Topical mecamylamine for diabetic macular edema. Campochiaro PA, Shah SM, Hafiz G, Heier JS, Lit ES, Zimmer-Galler I, Channa R, Nguyen QD, Syed B, Do DV, Lu L, Monk J, Cooke JP, Kengatharan MK, Hsu HH. Am J Ophthalmol. 2010; 149 (5): 839-51.e1
• Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways. de Jesus Perez VA, Alastalo TP, Wu JC, Axelrod JD, Cooke JP, Amieva M, Rabinovitch M. J Cell Biol. 2009; 184 (1): 83-99
• Cell-free production of transducible transcription factors for nuclear reprogramming. Yang WC, Patel KG, Lee J, Ghebremariam YT, Wong HE, Cooke JP, Swartz JR. Biotechnol Bioeng. 2009; 104 (6): 1047-58
• Does improving mood in depressed patients alter factors that may affect cardiovascular disease risk? Taylor CB, Conrad A, Wilhelm FH, Strachowski D, Khaylis A, Neri E, Giese-Davis J, Roth WT, Cooke JP, Kraemer H, Spiegel D. J Psychiatr Res. 2009; 43 (16): 1246-52
• Extensive characterization of the human DDAH1 transgenic mice. Schwedhelm E, von Leitner EC, Atzler D, Schmitz C, Jacobi J, Meinertz T, Münzel T, Baldus S, Cooke JP, Böger RH, Maas R, Sydow K. Pharmacol Res. 2009; 60 (6): 494-502
• Hypercholesterolemia impairs exercise capacity in mice. Maxwell AJ, Niebauer J, Lin PS, Tsao PS, Bernstein D, Cooke JP. Vasc Med. 2009; 14 (3): 249-57
• Murine model of hindlimb ischemia. Niiyama H, Huang NF, Rollins MD, Cooke JP. J Vis Exp. 2009; (23)
• nAChRs mediate human embryonic stem cell-derived endothelial cells: proliferation, apoptosis, and angiogenesis. Yu J, Huang NF, Wilson KD, Velotta JB, Huang M, Li Z, Lee A, Robbins RC, Cooke JP, Wu JC. PLoS One. 2009; 4 (9): e7040
• Asymmetric dimethylarginine and cardiac allograft vasculopathy progression: modulation by sirolimus. Potena L, Fearon WF, Sydow K, Holweg C, Luikart H, Chin C, Weisshaar D, Mocarski ES, Lewis DB, Valantine HA, Cooke JP. Transplantation. 2008; 85 (6): 827-33
• Endothelial nicotinic acetylcholine receptors and angiogenesis. Cooke JP, Ghebremariam YT. Trends Cardiovasc Med. 2008; 18 (7): 247-53
• Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation. Dayoub H, Rodionov RN, Lynch C, Cooke JP, Arning E, Bottiglieri T, Lentz SR, Faraci FM. Stroke. 2008; 39 (1): 180-4
• Two cardiovascular risk factors in one? Homocysteine and its relation to glomerular filtration rate. A meta-analysis of 41 studies with 27,000 participants. Kielstein JT, Salpeter SR, Buckley NS, Cooke JP, Fliser D. Kidney Blood Press Res. 2008; 31 (4): 259-67
• A novel bioluminescent tumor model of human renal cancer cell lines: an in vitro and in vivo characterization. Peter C, Kielstein JT, Clarke-Katzenberg R, Adams MC, Pitsiouni M, Kambham N, Karimi MA, Kengatharan KM, Cooke JP. J Urol. 2007; 177 (6): 2342-6
• Angiogenesis and the role of the endothelial nicotinic acetylcholine receptor. Cooke JP, Life Sci. 2007; 80 (24-25): 2347-51
• Beta2-microglobulin as a biomarker in peripheral arterial disease: proteomic profiling and clinical studies. Wilson AM, Kimura E, Harada RK, Nair N, Narasimhan B, Meng XY, Zhang F, Beck KR, Olin JW, Fung ET, Cooke JP. Circulation. 2007; 116 (12): 1396-403
• Changes in coronary arterial dimensions early after cardiac transplantation. Fearon WF, Potena L, Hirohata A, Sakurai R, Yamasaki M, Luikart H, Lee J, Vana ML, Cooke JP, Mocarski ES, Yeung AC, Valantine HA. Transplantation. 2007; 83 (6): 700-5
• Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease. Li Z, Wu JC, Sheikh AY, Kraft D, Cao F, Xie X, Patel M, Gambhir SS, Robbins RC, Cooke JP, Wu JC. Circulation. 2007; 116 (11 Suppl): I46-54
• Dimethylarginine dimethylaminohydrolase promotes endothelial repair after vascular injury. Konishi H, Sydow K, Cooke JP. J Am Coll Cardiol. 2007; 49 (10): 1099-105
• Frequent occult infection with Cytomegalovirus in cardiac transplant recipients despite antiviral prophylaxis. Potena L, Holweg CT, Vana ML, Bashyam L, Rajamani J, McCormick AL, Cooke JP, Valantine HA, Mocarski ES. J Clin Microbiol. 2007; 45 (6): 1804-10
• Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology. Knowles JW, Assimes TL, Li J, Quertermous T, Cooke JP. Arterioscler Thromb Vasc Biol. 2007; 27 (10): 2068-78
• L-arginine supplementation in peripheral arterial disease: no benefit and possible harm. Wilson AM, Harada R, Nair N, Balasubramanian N, Cooke JP. Circulation. 2007; 116 (2): 188-95
• NOx and ADMA changes with focal ischemia, amelioration with the chaperonin GroEL. Xu L, Wang B, Kaur K, Kho MF, Cooke JP, Giffard RG. Neurosci Lett. 2007; 418 (2): 201-4
• Nonbone marrow-derived circulating progenitor cells contribute to postnatal neovascularization following tissue ischemia. Aicher A, Rentsch M, Sasaki K, Ellwart JW, Fändrich F, Siebert R, Cooke JP, Dimmeler S, Heeschen C. Circ Res. 2007; 100 (4): 581-9
• SVMB Presidential address: Vascular medicine: past, present and future. Cooke JP, Vasc Med. 2007; 12 (3): 215-8
• Should we measure asymmetric dimethylarginine in patients with coronary artery disease? Kielstein JT, Cooke JP. Clin Chem. 2007; 53 (2): 161-3
• Psychophysiological and cortisol responses to psychological stress in depressed and nondepressed older men and women with elevated cardiovascular disease risk. Taylor CB, Conrad A, Wilhelm FH, Neri E, DeLorenzo A, Kramer MA, Giese-Davis J, Roth WT, Oka R, Cooke JP, Kraemer H, Spiegel D. Psychosom Med. 2006 Jul-Aug; 68 (4): 538-46
• A pilot study of ranolazine in patients with intermittent claudication. Ma A, Garland WT, Smith WB, Skettino S, Navarro MT, Chan AQ, Anderson BE, Cooke JP. Int Angiol. 2006; 25 (4): 361-9
• ADMA increases arterial stiffness and decreases cerebral blood flow in humans. Kielstein JT, Donnerstag F, Gasper S, Menne J, Kielstein A, Martens-Lobenhoffer J, Scalera F, Cooke JP, Fliser D, Bode-Böger SM. Stroke. 2006; 37 (8): 2024-9
• Acute rejection and cardiac allograft vascular disease is reduced by suppression of subclinical cytomegalovirus infection. Potena L, Holweg CT, Chin C, Luikart H, Weisshaar D, Narasimhan B, Fearon WF, Lewis DB, Cooke JP, Mocarski ES, Valantine HA. Transplantation. 2006; 82 (3): 398-405
• Endothelial progenitor cells participate in nicotine-mediated angiogenesis. Heeschen C, Chang E, Aicher A, Cooke JP. J Am Coll Cardiol. 2006; 48 (12): 2553-60
• Limb hemodynamics are not predictive of functional capacity in patients with PAD. Szuba A, Oka RK, Harada R, Cooke JP. Vasc Med. 2006; 11 (3): 155-63
• Microenvironmental VEGF distribution is critical for stable and functional vessel growth in ischemia. von Degenfeld G, Banfi A, Springer ML, Wagner RA, Jacobi J, Ozawa CR, Merchant MJ, Cooke JP, Blau HM. FASEB J. 2006; 20 (14): 2657-9
• Response to Letter by Tsuda. Kielstein JT, Donnerstag F, Gasper S, Menne J, Fliser D, Kielstein A, Martens-Lobenhoffer J, Scalera F, Bode-Boger SM, Cooke J. Stroke. 2006
• SVMB presidential address. The time has come for vascular medicine. Cooke JP, Vasc Med. 2006; 11 (3): 177-80
• Symmetric dimethylarginine (SDMA) as endogenous marker of renal function--a meta-analysis. Kielstein JT, Salpeter SR, Bode-Boeger SM, Cooke JP, Fliser D. Nephrol Dial Transplant. 2006; 21 (9): 2446-51
• T-cell immunity to subclinical cytomegalovirus infection reduces cardiac allograft disease. Tu W, Potena L, Stepick-Biek P, Liu L, Dionis KY, Luikart H, Fearon WF, Holmes TH, Chin C, Cooke JP, Valantine HA, Mocarski ES, Lewis DB. Circulation. 2006; 114 (15): 1608-15
• ADMA regulates angiogenesis: genetic and metabolic evidence. Achan V, Ho HK, Heeschen C, Stuehlinger M, Jang JJ, Kimoto M, Vallance P, Cooke JP. Vasc Med. 2005; 10 (1): 7-14
• ADMA: its role in vascular disease. Cooke JP, Vasc Med. 2005: 10 Suppl 1 S11-7
• Insulin resistance: potential role of the endogenous nitric oxide synthase inhibitor ADMA. Sydow K, Mondon CE, Cooke JP. Vasc Med. 2005: 10 Suppl 1 S35-43
• Mechanisms of Raynaud's disease. Cooke JP, Marshall JM. Vasc Med. 2005; 10 (4): 293-307
• Vascular compliance versus flow-mediated vasodilation: correlation with cardiovascular risk factors. Nair N, Oka RK, Waring LD, Umoh EM, Taylor CB, Cooke JP. Vasc Med. 2005; 10 (4): 275-83
• Adenoviral gene transfer with soluble vascular endothelial growth factor receptors impairs angiogenesis and perfusion in a murine model of hindlimb ischemia. Jacobi J, Tam BY, Wu G, Hoffman J, Cooke JP, Kuo CJ. Circulation. 2004; 110 (16): 2424-9
• Capillary electrophoretic and micellar electrokinetic separations of asymmetric dimethyl-L-arginine and structurally related amino acids: quantitation in human plasma. Trapp G, Sydow K, Dulay MT, Chou T, Cooke JP, Zare RN. J Sep Sci. 2004; 27 (17-18): 1483-90
• Cytomegalovirus infection impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine in transplant arteriosclerosis. Weis M, Kledal TN, Lin KY, Panchal SN, Gao SZ, Valantine HA, Mocarski ES, Cooke JP. Circulation. 2004; 109 (4): 500-5
• Developmental endothelial locus-1 (Del-1), a novel angiogenic protein: its role in ischemia. Ho HK, Jang JJ, Kaji S, Spektor G, Fong A, Yang P, Hu BS, Schatzman R, Quertermous T, Cooke JP. Circulation. 2004; 109 (10): 1314-9
• Discordant effects of a soluble VEGF receptor on wound healing and angiogenesis. Jacobi J, Tam BY, Sundram U, von Degenfeld G, Blau HM, Kuo CJ, Cooke JP. Gene Ther. 2004; 11 (3): 302-9
• Isoflavones improve vascular reactivity in post-menopausal women with hypercholesterolemia. Lissin LW, Oka R, Lakshmi S, Cooke JP. Vasc Med. 2004; 9 (1): 26-30
• Nicotine and angiogenesis: a new paradigm for tobacco-related diseases. Cooke JP, Bitterman H. Ann Med. 2004; 36 (1): 33-40
• The pivotal role of nitric oxide for vascular health. Cooke JP, Can J Cardiol. 2004: 20 Suppl B 7B-15B
• A novel mechanism for pulmonary arterial hypertension? Cooke JP, Circulation. 2003; 108 (12): 1420-1
• Cardiac allograft vasculopathy and dysregulation of the NO synthase pathway. Weis M, Cooke JP. Arterioscler Thromb Vasc Biol. 2003; 23 (4): 567-75
• Endothelial dysfunction induced by hyperhomocyst(e)inemia: role of asymmetric dimethylarginine. Stühlinger MC, Oka RK, Graf EE, Schmölzer I, Upson BM, Kapoor O, Szuba A, Malinow MR, Wascher TC, Pachinger O, Cooke JP. Circulation. 2003; 108 (8): 933-8
• Flow, NO, and atherogenesis. Cooke JP, Proc Natl Acad Sci U S A. 2003; 100 (3): 768-70
• Flow-responsive remodeling after angioplasty is enhanced by high cholesterol diet. Prevention with pyrrolidine dithiocarbamate. Ward MR, Tsao PS, Herity NA, Cooke JP, Yeung AC. Atherosclerosis. 2003; 168 (2): 333-41
• NO and angiogenesis. Cooke JP, Atheroscler Suppl. 2003; 4 (4): 53-60
• NOS inhibition accelerates atherogenesis: reversal by exercise. Niebauer J, Maxwell AJ, Lin PS, Wang D, Tsao PS, Cooke JP. Am J Physiol Heart Circ Physiol. 2003; 285 (2): H535-40
• Nicotine promotes arteriogenesis. Heeschen C, Weis M, Cooke JP. J Am Coll Cardiol. 2003; 41 (3): 489-96
• Effect of local delivery of L-arginine on in-stent restenosis in humans. Suzuki T, Hayase M, Hibi K, Hosokawa H, Yokoya K, Fitzgerald PJ, Yock PG, Cooke JP, Suzuki T, Yeung AC. Am J Cardiol. 2002; 89 (4): 363-7
• Endothelial determinants of dendritic cell adhesion and migration: new implications for vascular diseases. Weis M, Schlichting CL, Engleman EG, Cooke JP. Arterioscler Thromb Vasc Biol. 2002; 22 (11): 1817-23
• Metformin treatment lowers asymmetric dimethylarginine concentrations in patients with type 2 diabetes. Asagami T, Abbasi F, Stuelinger M, Lamendola C, McLaughlin T, Cooke JP, Reaven GM, Tsao PS. Metabolism. 2002; 51 (7): 843-6
• Nicotine accelerates angiogenesis and wound healing in genetically diabetic mice. Jacobi J, Jang JJ, Sundram U, Dayoub H, Fajardo LF, Cooke JP. Am J Pathol. 2002; 161 (1): 97-104
• Relationship between insulin resistance and an endogenous nitric oxide synthase inhibitor. Stühlinger MC, Abbasi F, Chu JW, Lamendola C, McLaughlin TL, Cooke JP, Reaven GM, Tsao PS. JAMA. 2002; 287 (11): 1420-6
• Short polymers of arginine rapidly translocate into vascular cells: effects on nitric oxide synthesis. Uemura S, Rothbard JB, Matsushita H, Tsao PS, Fathman CG, Cooke JP. Circ J. 2002; 66 (12): 1155-60
• Statins have biphasic effects on angiogenesis. Weis M, Heeschen C, Glassford AJ, Cooke JP. Circulation. 2002; 105 (6): 739-45
• Atherogenesis and the arginine hypothesis. Cooke JP, Oka RK. Curr Atheroscler Rep. 2001; 3 (3): 252-9
• Cholesterol-induced upregulation of angiotensin II and its effects on monocyte-endothelial interaction and superoxide production. Niebauer J, Tsao PS, Lin PS, Pratt RE, Cooke JP. Vasc Med. 2001; 6 (3): 133-8
• Homocysteine impairs the nitric oxide synthase pathway: role of asymmetric dimethylarginine. Stühlinger MC, Tsao PS, Her JH, Kimoto M, Balint RF, Cooke JP. Circulation. 2001; 104 (21): 2569-75
• L-arginine enhances aerobic exercise capacity in association with augmented nitric oxide production. Maxwell AJ, Ho HV, Le CQ, Lin PS, Bernstein D, Cooke JP. J Appl Physiol. 2001; 90 (3): 933-8
• Maintaining the endothelium: preventive strategies for vessel integrity. Lissin LW, Cooke JP. Prev Cardiol. 2001; 4 (1): 28-37
• Nicotine is an agent of angiogenesis. Nicotine stimulates angiogenesis and promotes tumor growth and atherosclerosis. Heeschen C, et al. Nat Med. 2001; 7 (7): 833-9
• Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus. Abbasi F, Asagmi T, Cooke JP, Lamendola C, McLaughlin T, Reaven GM, Stuehlinger M, Tsao PS. Am J Cardiol. 2001; 88 (10): 1201-3
• eNOS activity is reduced in senescent human endothelial cells: Preservation by hTERT immortalization. Matsushita H, Chang E, Glassford AJ, Cooke JP, Chiu CP, Tsao PS. Circ Res. 2001; 89 (9): 793-8
• An endogenous inhibitor of nitric oxide synthase regulates endothelial adhesiveness for monocytes. Böger RH, Bode-Böger SM, Tsao PS, Lin PS, Chan JR, Cooke JP. J Am Coll Cardiol. 2000; 36 (7): 2287-95
• Angiogenesis is impaired by hypercholesterolemia: role of asymmetric dimethylarginine. Jang JJ, Ho HK, Kwan HH, Fajardo LF, Cooke JP. Circulation. 2000; 102 (12): 1414-9
• Asymmetric dimethylarginine increases mononuclear cell adhesiveness in hypercholesterolemic humans. Chan JR, Böger RH, Bode-Böger SM, Tangphao O, Tsao PS, Blaschke TF, Cooke JP. Arterioscler Thromb Vasc Biol. 2000; 20 (4): 1040-6
• Decongestive lymphatic therapy for patients with cancer-related or primary lymphedema. Szuba A, Cooke JP, Yousuf S, Rockson SG. Am J Med. 2000; 109 (4): 296-300
• Differential expression of nitric oxide by dermal microvascular endothelial cells from patients with scleroderma. Romero LI, Zhang DN, Cooke JP, Ho HK, Avalos E, Herrera R, Herron GS. Vasc Med. 2000; 5 (3): 147-58
• Does ADMA cause endothelial dysfunction? Cooke JP, Arterioscler Thromb Vasc Biol. 2000; 20 (9): 2032-7
• Maintaining the endothelium: preventive strategies for vessel integrity. Wroblewski Lissin L, Cooke JP. Prev Cardiol. 2000; 3 (4): 172-177
• Photoangioplasty for human peripheral atherosclerosis: results of a phase I trial of photodynamic therapy with motexafin lutetium (Antrin). Rockson SG, Kramer P, Razavi M, Szuba A, Filardo S, Fitzgerald P, Cooke JP, Yousuf S, DeVault AR, Renschler MF, Adelman DC. Circulation. 2000; 102 (19): 2322-4
• Phytoestrogens and cardiovascular health. Lissin LW, Cooke JP. J Am Coll Cardiol. 2000; 35 (6): 1403-10
• Rapid and efficient vascular transport of arginine polymers inhibits myointimal hyperplasia. Uemura S, Fathman CG, Rothbard JB, Cooke JP. Circulation. 2000; 102 (21): 2629-35
• The endothelium: a new target for therapy. Cooke JP, Vasc Med. 2000; 5 (1): 49-53
• Fibroblast growth factor as therapy for critical limb ischemia: a case report. Cooke JP, Bhatnagar R, Szuba A, Rockson SG. Vasc Med. 1999; 4 (2): 89-91
• Gene transfer of nitric oxide synthase: effects on endothelial biology. Niebauer J, Dulak J, Chan JR, Tsao PS, Cooke JP. J Am Coll Cardiol. 1999; 34 (4): 1201-7
• Impaired aerobic capacity in hypercholesterolemic mice: partial reversal by exercise training. Niebauer J, Maxwell AJ, Lin PS, Tsao PS, Kosek J, Bernstein D, Cooke JP. Am J Physiol. 1999; 276 (4 Pt 2): H1346-54
• L-arginine and nitric oxide-related compounds in plasma: comparison of normal and arginine-free diets in a 24-h crossover study. Tangphao O, Chalon S, Coulston AM, Moreno H, Chan JR, Cooke JP, Hoffman BB, Blaschke TF. Vasc Med. 1999; 4 (1): 27-32
• Local L-arginine delivery after balloon angioplasty reduces monocyte binding and induces apoptosis. Niebauer J, Schwarzacher SP, Hayase M, Wang B, Kernoff RS, Cooke JP, Yeung AC. Circulation. 1999; 100 (17): 1830-5
• Mononuclear cell adherence to cultured endothelium is enhanced by hypertension and insulin resistance in healthy nondiabetic volunteers. Chen NG, Abbasi F, Lamendola C, McLaughlin T, Cooke JP, Tsao PS, Reaven GM. Circulation. 1999; 100 (9): 940-3
• Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP. Circulation. 1999; 99 (24): 3092-5
• Regression of atherosclerosis: role of nitric oxide and apoptosis. Wang BY, Ho HK, Lin PS, Schwarzacher SP, Pollman MJ, Gibbons GH, Tsao PS, Cooke JP. Circulation. 1999; 99 (9): 1236-41
• [Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis]. Miyazaki H, Matsuoka H, Cooke JP, Usui M, Ueda S, Okuda S, Imaizumi T. J Cardiol. 1999; 33 (2): 105-6
• Asymmetric dimethylarginine (ADMA): a novel risk factor for endothelial dysfunction: its role in hypercholesterolemia. Böger RH, Bode-Böger SM, Szuba A, Tsao PS, Chan JR, Tangphao O, Blaschke TF, Cooke JP. Circulation. 1998; 98 (18): 1842-7
• Cardiovascular effects of L-arginine. Maxwell AJ, Cooke JP. Curr Opin Nephrol Hypertens. 1998; 7 (1): 63-70
• Endothelial alterations in hypercholesterolemia: more than simply vasodilator dysfunction. Tsao PS, Cooke JP. J Cardiovasc Pharmacol. 1998: 32 Suppl 3 S48-53
• Images in vascular medicine. Phlegmasia coerulea dolens--venous gangrene. Szuba A, Cooke JP, Rockson SG. Vasc Med. 1998; 3 (1): 29-31
• Interaction of diabetes and hypertension on determinants of endothelial adhesiveness. Tsao PS, Niebauer J, Buitrago R, Lin PS, Wang BY, Cooke JP, Chen YD, Reaven GM. Arterioscler Thromb Vasc Biol. 1998; 18 (6): 947-53
• Is atherosclerosis an arginine deficiency disease? Cooke JP, J Investig Med. 1998; 46 (8): 377-80
• Limb blood flow during exercise is dependent on nitric oxide. Maxwell AJ, Schauble E, Bernstein D, Cooke JP. Circulation. 1998; 98 (4): 369-74
• Nutriceuticals for cardiovascular health. Cooke JP, Am J Cardiol. 1998; 82 (10A): 43S-46S
• Peripheral arterial insufficiency: mechanisms, natural history, and therapeutic options. Rockson SG, Cooke JP. Adv Intern Med. 1998: 43 253-77
• Thromboangiitis obliterans. An update on Buerger's disease. Szuba A, Cooke JP. West J Med. 1998; 168 (4): 255-60
• Adherence of mononuclear cells to endothelium in vitro is increased in patients with NIDDM. Carantoni M, Abbasi F, Chu L, Chen YD, Reaven GM, Tsao PS, Varasteh B, Cooke JP. Diabetes Care. 1997; 20 (9): 1462-5
• Adhesiveness of mononuclear cells in hypercholesterolemic humans is normalized by dietary L-arginine. Theilmeier G, Chan JR, Zalpour C, Anderson B, Wang BY, Wolf A, Tsao PS, Cooke JP. Arterioscler Thromb Vasc Biol. 1997; 17 (12): 3557-64
• Anti-CD43 inhibits monocyte-endothelial adhesion in inflammation and atherogenesis. McEvoy LM, Jutila MA, Tsao PS, Cooke JP, Butcher EC. Blood. 1997; 90 (9): 3587-94
• Dietary L-arginine supplementation normalizes platelet aggregation in hypercholesterolemic humans. Wolf A, Zalpour C, Theilmeier G, Wang BY, Ma A, Anderson B, Tsao PS, Cooke JP. J Am Coll Cardiol. 1997; 29 (3): 479-85
• Local intramural delivery of L-arginine enhances nitric oxide generation and inhibits lesion formation after balloon angioplasty. Schwarzacher SP, Lim TT, Wang B, Kernoff RS, Niebauer J, Cooke JP, Yeung AC. Circulation. 1997; 95 (7): 1863-9
• Nitric oxide regulates monocyte chemotactic protein-1. Tsao PS, Wang B, Buitrago R, Shyy JY, Cooke JP. Circulation. 1997; 96 (3): 934-40
• Nitric oxide synthase: role in the genesis of vascular disease. Cooke JP, Dzau VJ. Annu Rev Med. 1997: 48 489-509
• Novel vascular molecule involved in monocyte adhesion to aortic endothelium in models of atherogenesis. McEvoy LM, Sun H, Tsao PS, Cooke JP, Berliner JA, Butcher EC. J Exp Med. 1997; 185 (12): 2069-77
• Role of digital artery adrenoceptors in Raynaud's disease. Cooke JP, Creager SJ, Scales KM, Ren C, Tsapatsaris NP, Beetham WP, Creager MA. Vasc Med. 1997; 2 (1): 1-7
• The pathophysiology of peripheral arterial disease: rational targets for drug intervention. Cooke JP, Vasc Med. 1997; 2 (3): 227-30
• Therapeutic interventions in endothelial dysfunction: endothelium as a target organ. Cooke JP, Clin Cardiol. 1997; 20 (11 Suppl 2): II-45-51
• A novel therapy for lymphedema complicated by lymphorrhea. Szuba A, Cooke JP, Rockson SG. Vasc Med. 1996; 1 (4): 247-50
• Acute myocardial infarction in a young woman with systemic lupus erythematosus. Fearon WF, Cooke JP. Vasc Med. 1996; 1 (1): 19-23
• Arginine restores nitric oxide activity and inhibits monocyte accumulation after vascular injury in hypercholesterolemic rabbits. Wang BY, Candipan RC, Arjomandi M, Hsiun PT, Tsao PS, Cooke JP. J Am Coll Cardiol. 1996; 28 (6): 1573-9
• Cardiovascular effects of exercise: role of endothelial shear stress. Niebauer J, Cooke JP. J Am Coll Cardiol. 1996; 28 (7): 1652-60
• Felodipine inhibits intimal lesion formation in the hypercholesterolemic rabbit: differential effects on endothelial and monocyte determinants of atherogenesis. Wang BY, Niebauer J, Singer AH, Tsao PS, Cooke JP. Vasc Med. 1996; 1 (3): 173-9
• Fluid flow inhibits endothelial adhesiveness. Nitric oxide and transcriptional regulation of VCAM-1. Tsao PS, Buitrago R, Chan JR, Cooke JP. Circulation. 1996; 94 (7): 1682-9
• Hypertension-enhanced monocyte adhesion in experimental atherosclerosis. Tropea BI, Huie P, Cooke JP, Tsao PS, Sibley RK, Zarins CK. J Vasc Surg. 1996; 23 (4): 596-605
• Induction of nitric oxide synthase in the human cardiac allograft is associated with contractile dysfunction of the left ventricle. Lewis NP, Tsao PS, Rickenbacher PR, Xue C, Johns RA, Haywood GA, von der Leyen H, Trindade PT, Cooke JP, Hunt SA, Billingham ME, Valantine HA, Fowler MB. Circulation. 1996; 93 (4): 720-9
• Regression or progression. Dependency on vascular nitric oxide. Candipan RC, Wang BY, Buitrago R, Tsao PS, Cooke JP. Arterioscler Thromb Vasc Biol. 1996; 16 (1): 44-50
• Role of nitric oxide in progression and regression of atherosclerosis. Cooke JP, West J Med. 1996; 164 (5): 419-24
• Discordant effects of dietary L-arginine on vascular structure and reactivity in hypercholesterolemic rabbits. Singer AH, Tsao PS, Wang BY, Bloch DA, Cooke JP. J Cardiovasc Pharmacol. 1995; 25 (5): 710-6
• Exposure to shear stress alters endothelial adhesiveness. Role of nitric oxide. Tsao PS, Lewis NP, Alpert S, Cooke JP. Circulation. 1995; 92 (12): 3513-9
• Fluid shear stress induces endothelial transforming growth factor beta-1 transcription and production. Modulation by potassium channel blockade. Ohno M, Cooke JP, Dzau VJ, Gibbons GH. J Clin Invest. 1995; 95 (3): 1363-9
• Gene therapy inhibiting neointimal vascular lesion: in vivo transfer of endothelial cell nitric oxide synthase gene. von der Leyen HE, Gibbons GH, Morishita R, Lewis NP, Zhang L, Nakajima M, Kaneda Y, Cooke JP, Dzau VJ. Proc Natl Acad Sci U S A. 1995; 92 (4): 1137-41
• Genetic engineering of vein grafts resistant to atherosclerosis. Mann MJ, Gibbons GH, Kernoff RS, Diet FP, Tsao PS, Cooke JP, Kaneda Y, Dzau VJ. Proc Natl Acad Sci U S A. 1995; 92 (10): 4502-6
• Medical therapy of peripheral arterial occlusive disease. Cooke JP, Ma AO. Surg Clin North Am. 1995; 75 (4): 569-79
• The role of coronary angiography and coronary revascularization before noncardiac vascular surgery. Mason JJ, Owens DK, Harris RA, Cooke JP, Hlatky MA. JAMA. 1995; 273 (24): 1919-25
• Dietary arginine prevents atherogenesis in the coronary artery of the hypercholesterolemic rabbit. Wang BY, Singer AH, Tsao PS, Drexler H, Kosek J, Cooke JP. J Am Coll Cardiol. 1994; 23 (2): 452-8
• Effect of L-arginine on coronary endothelial function in cardiac transplant recipients. Relation to vessel wall morphology. Drexler H, Fischell TA, Pinto FJ, Chenzbraun A, Botas J, Cooke JP, Alderman EL. Circulation. 1994; 89 (4): 1615-23
• Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine. Tsao PS, McEvoy LM, Drexler H, Butcher EC, Cooke JP. Circulation. 1994; 89 (5): 2176-82
• L-arginine attenuates platelet reactivity in hypercholesterolemic rabbits. Tsao PS, Theilmeier G, Singer AH, Leung LL, Cooke JP. Arterioscler Thromb. 1994; 14 (10): 1529-33
• The vasculopathy of aging. Cooper LT, Cooke JP, Dzau VJ. J Gerontol. 1994; 49 (5): B191-6
• Vascular injury augments adrenergic neurotransmission. Candipan RC, Hsiun PT, Pratt R, Cooke JP. Circulation. 1994; 89 (2): 777-84
• Shear stress elevates endothelial cGMP. Role of a potassium channel and G protein coupling. Ohno M, Gibbons GH, Dzau VJ, Cooke JP. Circulation. 1993; 88 (1): 193-7
• Vascular biology and medicine in the 1990s: scope, concepts, potentials, and perspectives. Dzau VJ, Gibbons GH, Cooke JP, Omoigui N. Circulation. 1993; 87 (3): 705-19
• Antiatherogenic effects of L-arginine in the hypercholesterolemic rabbit. Cooke JP, Singer AH, Tsao P, Zera P, Rowan RA, Billingham ME. J Clin Invest. 1992; 90 (3): 1168-72
• The role of endothelial dysfunction in restenosis. Cooke JP, Tsao PS. Rev Port Cardiol. 1992; 11 (10): 889-92
• Endothelial dysfunction in hypercholesterolemia is corrected by L-arginine. Cooke JP, Dzau J, Creager A. Basic Res Cardiol. 1991: 86 Suppl 2 173-81
• Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator. Cooke JP, Rossitch E, Andon NA, Loscalzo J, Dzau VJ. J Clin Invest. 1991; 88 (5): 1663-71