Holbrook Kohrt

Publications

• Adoptive cell therapy for lymphoma with CD4 T cells depleted of CD137-expressing regulatory T cells. Goldstein MJ, Kohrt HE, Houot R, Varghese B, Lin JT, Swanson E, Levy R. Cancer Res. 2012; 72 (5): 1239-47
• CD137 is expressed in follicular dendritic cell tumors and in classical Hodgkin and T-cell lymphomas: diagnostic and therapeutic implications. Anderson MW, Zhao S, Freud AG, Czerwinski DK, Kohrt H, Alizadeh AA, Houot R, Azambuja D, Biasoli I, Morais JC, Spector N, Molina-Kirsch HF, Warnke RA, Levy R, Natkunam Y. Am J Pathol. 2012; 181 (3): 795-803
• Co-transplantation of pure blood stem cells with antigen-specific but not bulk T cells augments functional immunity. Müller AM, Shashidhar S, Küpper NJ, Kohrt HE, Florek M, Negrin RS, Brown JM, Shizuru JA. Proc Natl Acad Sci U S A. 2012; 109 (15): 5820-5
• Combination strategies to enhance antitumor ADCC. Kohrt HE, Houot R, Marabelle A, Cho HJ, Osman K, Goldstein M, Levy R, Brody J. Immunotherapy. 2012; 4 (5): 511-27
• Long-term outcome of patients with metastatic breast cancer treated with high-dose chemotherapy and transplantation of purified autologous hematopoietic stem cells. Müller AM, Kohrt HE, Cha S, Laport G, Klein J, Guardino AE, Johnston LJ, Stockerl-Goldstein KE, Hanania E, Juttner C, Blume KG, Negrin RS, Weissman IL, Shizuru JA. Biol Blood Marrow Transplant. 2012; 18 (1): 125-33
• Rapid development of exhaustion and down-regulation of eomesodermin limit the antitumor activity of adoptively transferred murine natural killer cells. Gill S, Vasey AE, De Souza A, Baker J, Smith AT, Kohrt HE, Florek M, Gibbs KD, Tate K, Ritchie DS, Negrin RS. Blood. 2012; 119 (24): 5758-68
• Tailored temozolomide therapy according to MGMT methylation status for elderly patients with acute myeloid leukemia. Medeiros BC, Kohrt HE, Gotlib J, Coutre SE, Zhang B, Arber DA, Zehnder JL. Am J Hematol. 2012; 87 (1): 45-50
• The chemoattractant chemerin suppresses melanoma by recruiting natural killer cell antitumor defenses. Pachynski RK, Zabel BA, Kohrt HE, Tejeda NM, Monnier J, Swanson CD, Holzer AK, Gentles AJ, Sperinde GV, Edalati A, Hadeiba HA, Alizadeh AA, Butcher EC. J Exp Med. 2012; 209 (8): 1427-35
• What happened to the concept of the physician-scientist? Goldstein MJ, Kohrt HE. Acad Med. 2012; 87 (2): 132-3
• A CpG-loaded tumor cell vaccine induces antitumor CD4+ T cells that are effective in adoptive therapy for large and established tumors. Goldstein MJ, Varghese B, Brody JD, Rajapaksa R, Kohrt H, Czerwinski DK, Levy S, Levy R. Blood. 2011; 117 (1): 118-27
• Active and passive immunotherapy for lymphoma: proving principles and improving results. Brody J, Kohrt H, Marabelle A, Levy R. J Clin Oncol. 2011; 29 (14): 1864-75
• Acute myeloid leukaemia in the elderly: a review. Pollyea DA, Kohrt HE, Medeiros BC. Br J Haematol. 2011; 152 (5): 524-42
• CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies. Kohrt HE, Houot R, Goldstein MJ, Weiskopf K, Alizadeh AA, Brody J, Müller A, Pachynski R, Czerwinski D, Coutre S, Chao MP, Chen L, Tedder TF, Levy R. Blood. 2011; 117 (8): 2423-32
• CD8+CD44(hi) but not CD4+CD44(hi) memory T cells mediate potent graft antilymphoma activity without GVHD. Dutt S, Baker J, Kohrt HE, Kambham N, Sanyal M, Negrin RS, Strober S. Blood. 2011; 117 (11): 3230-9
• Cytotoxic T lymphocyte responses against melanocytes and melanoma. Chang GY, Kohrt HE, Stuge TB, Schwartz EJ, Weber JS, Lee PP. J Transl Med. 2011; 9 (1): 122
• Donor immunization with WT1 peptide augments antileukemic activity after MHC-matched bone marrow transplantation. Kohrt HE, Müller A, Baker J, Goldstein MJ, Newell E, Dutt S, Czerwinski D, Lowsky R, Strober S. Blood. 2011; 118 (19): 5319-29
• Prediction of survival in diffuse large B-cell lymphoma based on the expression of 2 genes reflecting tumor and microenvironment. Alizadeh AA, Gentles AJ, Alencar AJ, Liu CL, Kohrt HE, Houot R, Goldstein MJ, Zhao S, Natkunam Y, Advani RH, Gascoyne RD, Briones J, Tibshirani RJ, Myklebust JH, Plevritis SK, Lossos IS, Levy R. Blood. 2011; 118 (5): 1350-8
• Selective resistance of CD44hi T cells to p53-dependent cell death results in persistence of immunologic memory after total body irradiation. Yao Z, Jones J, Kohrt H, Strober S. J Immunol. 2011; 187 (8): 4100-8
• Anti-CD47 antibody synergizes with rituximab to promote phagocytosis and eradicate non-Hodgkin lymphoma. Chao MP, Alizadeh AA, Tang C, Myklebust JH, Varghese B, Gill S, Jan M, Cha AC, Chan CK, Tan BT, Park CY, Zhao F, Kohrt HE, Malumbres R, Briones J, Gascoyne RD, Lossos IS, Levy R, Weissman IL, Majeti R. Cell. 2010; 142 (5): 699-713
• Immunophenotypic features of acute myeloid leukemia with inv(3)(q21q26.2)/t(3;3)(q21;q26.2). Medeiros BC, Kohrt HE, Arber DA, Bangs CD, Cherry AM, Majeti R, Kogel KE, Azar CA, Patel S, Alizadeh AA. Leuk Res. 2010; 34 (5): 594-7
• NKT cells, Treg, and their interactions in bone marrow transplantation. Kohrt HE, Pillai AB, Lowsky R, Strober S. Eur J Immunol. 2010; 40 (7): 1862-9
• Quantitative, architectural analysis of immune cell subsets in tumor-draining lymph nodes from breast cancer patients and healthy lymph nodes. Setiadi AF, Ray NC, Kohrt HE, Kapelner A, Carcamo-Cavazos V, Levic EB, Yadegarynia S, van der Loos CM, Schwartz EJ, Holmes S, Lee PP. PLoS One. 2010; 5 (8): e12420
• Risk stratification in extranodal natural killer/T-cell lymphoma. Kohrt H, Lee M, Advani R. Expert Rev Anticancer Ther. 2010; 10 (9): 1395-405
• Second-line mitoxantrone, etoposide, and cytarabine for acute myeloid leukemia: a single-center experience. Kohrt HE, Patel S, Ho M, Owen T, Pollyea DA, Majeti R, Gotlib J, Coutre S, Liedtke M, Berube C, Alizadeh AA, Medeiros BC. Am J Hematol. 2010; 85 (11): 877-81
• Dynamic CD8 T-cell responses to tumor-associated Epstein-Barr virus antigens in patients with Epstein-Barr virus-negative Hodgkin's disease. Kohrt H, Johannsen A, Hoppe R, Horning SJ, Rosenberg SA, Advani R, Lee PP. Oncol Res. 2009; 18 (5-6): 287-92
• Extranodal natural killer/T-cell lymphoma: current concepts in biology and treatment. Kohrt H, Advani R. Leuk Lymphoma. 2009; 50 (11): 1773-84
• Nonmyeloablative conditioning with total lymphoid irradiation and antithymocyte globulin: an update. Kohrt H, Lowsky R. Curr Opin Hematol. 2009; 16 (6): 460-5
• TLI and ATG conditioning with low risk of graft-versus-host disease retains antitumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors. Kohrt HE, Turnbull BB, Heydari K, Shizuru JA, Laport GG, Miklos DB, Johnston LJ, Arai S, Weng WK, Hoppe RT, Lavori PW, Blume KG, Negrin RS, Strober S, Lowsky R. Blood. 2009; 114 (5): 1099-109
• Therapeutic effect of CD137 immunomodulation in lymphoma and its enhancement by Treg depletion. Houot R, Goldstein MJ, Kohrt HE, Myklebust JH, Alizadeh AA, Lin JT, Irish JM, Torchia JA, Kolstad A, Chen L, Levy R. Blood. 2009; 114 (16): 3431-8
• Total lymphoid irradiation for graft-versus-host disease protection. Kohrt H, Lowsky R. Curr Opin Oncol. 2009: 21 Suppl 1 S23-6
• Massive splenic infarct in a collegiate football player with hemoglobin SC disease. Ouyang DL, Kohrt HE, Garza D, Matheson GO. Clin J Sport Med. 2008; 18 (1): 89-91
• New models and online calculator for predicting non-sentinel lymph node status in sentinel lymph node positive breast cancer patients. Kohrt HE, Olshen RA, Bermas HR, Goodson WH, Wood DJ, Henry S, Rouse RV, Bailey L, Philben VJ, Dirbas FM, Dunn JJ, Johnson DL, Wapnir IL, Carlson RW, Stockdale FE, Hansen NM, Jeffrey SS. BMC Cancer. 2008: 8 66
• Optimizing therapy for acute myeloid leukemia. Kohrt HE, Coutre SE. J Natl Compr Canc Netw. 2008; 6 (10): 1003-16
• Renal failure and rhabdomyolysis associated with sitagliptin and simvastatin use. Kao DP, Kohrt HE, Kugler J. Diabet Med. 2008; 25 (10): 1229-30
• Antiviral prophylaxis for chemotherapy-induced reactivation of chronic hepatitis B virus infection. Kohrt HE, Ouyang DL, Keeffe EB. Clin Liver Dis. 2007; 11 (4): 965-91, x
• Systematic review: lamivudine prophylaxis for chemotherapy-induced reactivation of chronic hepatitis B virus infection. Kohrt HE, Ouyang DL, Keeffe EB. Aliment Pharmacol Ther. 2006; 24 (7): 1003-16
• Rapid assessment of recognition efficiency and functional capacity of antigen-specific T-cell responses. Kohrt HE, Shu CT, Stuge TB, Holmes SP, Weber J, Lee PP. J Immunother. 2005 Jul-Aug; 28 (4): 297-305
• Profile of immune cells in axillary lymph nodes predicts disease-free survival in breast cancer. Kohrt HE, Nouri N, Nowels K, Johnson D, Holmes S, Lee PP. PLoS Med. 2005; 2 (9): e284
• An ecological-transactional model of significant risk factors for child psychopathology in outer mongolia. Kohrt HE, Kohrt BA, Waldman I, Saltzman K, Carrion VG. Child Psychiatry Hum Dev. 2004; 35 (2): 163-81