Sean P. David, M.D., D.Phil.

Community and International Work Details

• Project Title:  Study of Tobacco Use in Minority Populations (STOMP) Genetics Consortium
• Topic/emphasis:  Genetics, Smoking, African Americans
• Partnering Organization(s):  SRI International, Memorial Sloan-Kettering Cancer Center, Brown University and other institutions.
• Populations Served:  African Americans
• Location:  International
• Specific Location:  US
• This an ongoing project:  Yes
• There are opportunities for student involvement in work:  Yes
• Description:  The first paper from the STOMP Genetics Consortium is published in Translational Psychiatry: http://www.nature.com/tp/journal/v2/n5/full/tp201241a.html The genetic architecture of smoking-related traits is not well described in non-European ancestral groups, but there is evidence that genetic determinants have important implications for multiple addictive behaviors in populations globally. We established the Study of Tobacco in Minority Populations (STOMP) Genetics Consortium, which represents 13 GWAS studies of men and women of African ancestry, to search for risk loci for smoking behaviors in this population. The STOMP Genetics Consortium is comprised of the following studies: the Women's Health Initiative SNP Health Association Resource (n=8208), the African American GWAS consortia of Breast Cancer (n=5061) and Prostate Cancer (n=5556), the Candidate Gene Association Resource Consortium (including the Atherosclerosis Risk in Communities (n=2916) study, the Cleveland Family Study (n=632), the Coronary Artery Risk Development in Young Adults (n=953) study, the Jackson Heart Study (n=2145) and the Multi-Ethnic Study of Atherosclerosis (n=1646)), the Cardiovascular Health Study (n=801), the Healthy Aging in Neighborhoods across the Life Span Study (n=918), the Health ABC Study (n=1137), the Genetic Study of Atherosclerosis Risk (n=1175) and the Hypertension Genetic Epidemiology Network (n=1241).