Sean P. David, M.D., D.Phil.

Community and International Work Details

  • Project Title:  CYP2A6 genotype and smoking in China
  • Topic/emphasis:  Genetic influences on smoking
  • Partnering Organization(s):  Sun Yat-sen University; University of Toronto
  • Location:  International
  • Specific Location:  Guangzhou, P.R. China
  • This an ongoing project:  Yes
  • There are opportunities for student involvement in work:  Yes
  • Description:  The first paper was published in Addiction: http://onlinelibrary.wiley.com/doi/10.1111/j.1360-0443.2010.03353.x/suppinfo This project involves genotyping a cohort of more than 1,300 smokers in southeastern China for the cytochrome P450 (CYP2A6) enzyme gene, which moderates nicotine metabolism. CYP2A6 genotype is associated with hepatic nicotine metabolism and cigarette consumption rates. The role of genetics, tobacco and effects on chronic disease are being examined to identify biomarkers of tobacco cessation and prevention of chronic, non-communicable diseases.

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