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Kari Nadeau, MD, PhD

Academic Appointments

  • Associate Professor of Pediatrics (Allergy & Clinical Immunology) and, by courtesy, of Otolaryngology - Head and Neck Surgery at LPCH

Key Documents

Contact Information

Professional Overview

Clinical Focus

  • Allergy and Immunology
  • Adult and Pediatric Asthma, Allergy, and Immunology

Academic Appointments

Administrative Appointments

  • Associate Professor, Affiliate appointment in Otolaryngology (2011 - present)
  • Associate Professor, Pediatrics (2011 - present)
  • Faculty Member, Multidisciplinary Program in Immunology (2007 - present)
  • Faculty Member, Stanford Institute of Immunity, Transplantation and Infectious Disease (2007 - present)
  • Assistant Professor, Pediatrics (2007 - 2011)
  • Assistant Professor, Affiliate appointment in Otolaryngology (2007 - 2011)
View All 11administrative appointments of Kari Nadeau

Honors and Awards

  • Junior Faculty Award, Clinical Immunological Society (2010)
  • National Junior Faculty Award, American Lung Association (2009)
  • Fellow, American Academy of Asthma, Allergy and Immunology (2008-present)
  • Speaker Award, La Entrada Inspirational Speaker Series (2007)
  • National Junior Faculty Award, American Academy of Asthma, Allergy and Immunology (2007)
  • Stanford Free Clinics Teaching Award, Stanford Medical School (June 2007)
View All 9honors and awards of Kari Nadeau

Professional Education

Board Certification: Pediatrics, American Board of Pediatrics (2006)
Fellowship: Stanford University Medical Center CA (2006)
Residency: Children's Hospital Boston MA (1997)
Residency: Stanford University Medical Center CA (2004)
Internship: Children's Hospital Boston MA (1996)
Medical Education: Harvard Medical School MA (1995)
View All 9

Community and International Work

Courses

2013-14

Prior Year Coursescourses of Kari Nadeau

Graduate and Fellowship Program Affiliations

Scientific Focus

Current Research and Scholarly Interests

The Nadeau Laboratory focuses on the mechanisms of immune dysfunction in primary immune disease (PID), allergy, and asthma. In recent years, allergic disorders have reached epidemic proportions in children and adults. Many studies have determined that the immune system of patients with allergies (also called atopy), such as asthma, atopic dermatitis, food allergies, allergic rhinitis, allergic conjunctivitis and other atopic disorders, is overactive and skewed toward a certain subtype of immune cell called the Th2 cell. So far, there is little understanding of how cells turn off this abnormal proliferation and activation of the Th2 cell.

The Nadeau Laboratory has found that a type of cell, called the natural regulatory T cells (nTreg), can decrease Th2 cell overactivation in allergies, thus leading to improvement or even reversal of the allergic condition. By understanding how these Treg cells work, we hope to discover new diagnostic and therapeutic ways to treat or prevent allergic conditions.

The Nadeau Laboratory maintains a database and sample/tissue bank of healthy controls and patients treated at LPCH/Stanford Medical Center with allergic disorders. The main focus of our laboratory is five-fold:

1. To determine the role of STAT5a and STAT5b in Treg development and function;
2. Since Tregs may respond to pollution, we are studying the effect of ambient air pollution on Tregs;
3. Since most allergic conditions start in childhood, we are examining the role of Th2 and Treg in different age groups with and without allergies;
4. Since the activity of Th2 and Treg is determined by their interactions with other cell types, such as epithelial cells and dendritic cells, we are studying their effects on Th2/Treg interactions; and
5. Since improvement of Treg function is associated with improvement of allergic conditions, we are designing new allergy treatments (for example, sublingual immunotherapy, small molecule chemokines) that enhance Treg function.

Publications

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Publication Topics

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