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Eric Sibley, M.D., Ph.D.

Academic Appointments

  • Associate Professor of Pediatrics (Gastroenterology)

Key Documents

Contact Information

  • Clinical Offices
    Pediatric Gastroenterology 730 Welch Rd 2nd Fl Palo Alto, CA 94304
    Tel Work (650) 721-2250 Fax (650) 498-5608
  • Academic Offices
    Personal Information
    Email Tel (650) 723-5070
    Not for medical emergencies or patient use

Professional Overview

Clinical Focus

  • Gastroenterology/Nutrition/Hepatology, Pediatric
  • Pediatric Gastroenterology

Academic Appointments

Administrative Appointments

  • Assistant Dean for Academic Advising, Stanford University School of Medicine (2012 - present)
  • Senator, School of Medicine Faculty Senate (2009 - present)
  • Associate Director (Research), Stanford Pediatric Gastroenterology Training Program (2004 - present)
  • Chair/Vice-Chair, Growth, Development and Aging Section, American Gastroenterology Association (2007 - 2011)
  • Editor-In-Chief, Journal of Pediatric Gastroenterology and Nutrition (2006 - 2010)
  • Member, Clinical and Integrative Gastrointestinal Pathobiology Study Section, NIH (2004 - 2007)
View All 7administrative appointments of Eric Sibley

Honors and Awards

  • Member, American Clinical and Climatological Association (2010-present)
  • Council, elected, American Gastroenterology Association (2007-2011)
  • Council, elected, Society for Pediatric Research (2005-2008)
  • Named Investigator Award, Stanford Digestive Disease Center (2002-2003)
  • Young Faculty Investigator Award, North American Society for Pediatric Gastroenterology and Nutrition (1998)

Professional Education

Undergraduate Education: Harvard College, A.B., Biochemical Sciences (1982)
Medical Education: Johns Hopkins University School of Medicine MD (1990)
Graduate Education: The Johns Hopkins University, Ph.D., Biological Chemistry (1990)
Internship: Harbor-UCLA Medical Center CA (1991)
Residency: Harbor-UCLA Medical Center CA (1993)
Fellowship: Stanford University School of Medicine CA (1996)
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Scientific Focus

Current Research and Scholarly Interests

Transcriptional Regulation of Intestine-Specific Gene Expression during Gut Development and Maturation.

The mammalian gastrointestinal tract matures from a primitive tube into morphologically and functionally distinct regions during development. The mature small intestine functions in the digestion and absorption of ingested nutrients. Expression of several nutrient hydrolases is spatially restricted to distinct segments along the cephalo-caudal axis of the small intestine and is temporally regulated during postnatal maturation. Intestinal lactase, the hydrolase responsible for the digestion of lactose in milk, is expressed at highest levels in the jejunal segment of the small intestine shortly after birth and then declines dramatically just prior to weaning in most mammals.

Our research is directed towards defining the mechanisms regulating the spatial and temporal restriction of lactase gene expression during intestinal development. The normal maturational decline in lactase enzymatic activity is correlated with a decline in lactase messenger RNA levels and is transcriptionally regulated. We are currently identifying maturation-specific lactase gene cis elements and characterizing the nuclear proteins interacting with those elements in cell culture and transgenic animals. We seek to define the interactions of the lactase gene elements and nuclear factors involved in mediating transcriptional control. The overall goal is to relate these lactase control mechanisms to the broader pathways specifying acquisition of a small intestinal phenotype. We are also investigating gene transfer methods to deliver specific genes to the intestine.


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Publication Topics

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