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Edda Spiekerkoetter

Academic Appointments

  • Assistant Professor of Medicine (Pulmonary and Critical Care Medicine)

Key Documents

Contact Information

  • Clinical Offices
    Pulmonary and Critical Care Medicine 300 Pasteur Dr H3143 MC 5236 Stanford, CA 94305
    Tel Work (650) 723-6381 Fax (650) 725-5489
  • Academic Offices
    Personal Information
    Email Tel (650) 724-1493
    Not for medical emergencies or patient use

Professional Overview

Clinical Focus

  • Pulmonary Hypertension
  • Pulmonary Disease
  • Vasoreactivity in pulmonary hypertension as a marker of vascular remodeling
  • Biomarkers
  • Clinical Trial, Phase II

Academic Appointments

Honors and Awards

  • Manuscript Award, Cardiovascular Institute at Stanford (Feb 2014)
  • Poster Award, Excellence Cluster Cardio-Pulmonary System (ECCPS) and Pulmonary Vascular Research Institute (PVRI) (Jan 2014)
  • Helmholtz International Research Group Award, Helmholtz Zentrum Muenchen, Germany (2013-2016)
  • Seed Grant- BMP signaling in the RV, Cardiovascular Institute Stanford (2013-2014)
  • Seed Grant - Phase II Clinical Trial, Wall Center of Pulmonary Vascular Disease (2012-2014)
  • Seed Grant - Phase II Clinical Trial, SPARK and Spectrum Stanford (2012-2014)
View All 11honors and awards of Edda Spiekerkoetter

Boards, Advisory Committees, Professional Organizations

  • Pulmonary Circulation Program Committee, American Thoracic Society (2013 - present)
  • Member at large, European Respiratory Society (2000 - present)
  • Member at large, American Thoracic Society (1998 - present)

Professional Education

Fellowship: Stanford Hospital and Clinics - Critical Care CA (2009)
Fellowship: Stanford University CA (2008)
Fellowship: Lucile Packard Children's Hospital CA (2006)
Residency: Medizinische Hochschule Hannover, Germany (2002)
Medical Education: University Hospital Freiburg, Germany (1995)

Patents

  • Edda Spiekerkoetter. "United States Patent 61481317 Low-Dose FK506 for the treatment of Pulmonary Arterial Hypertension", Leland Stanford Junior University

Scientific Focus

Current Research and Scholarly Interests

My research focuses on the importance of the Bone Morphogenetic Protein Receptor 2 (BMPR2) signaling pathway in pulmonary, pulmonary-vascular as well as cardiac disease.

In 2000 two independent groups discovered mutations in the BMPR2 pathway as the genetic basis for pulmonary arterial hypertension (PAH). Over the past years more mutations either directly involved in the BMPR2 pathway (Endoglin, ALk1, Smad9) or indirectly linked to the BMPR2 pathway (Caveolin-1) have been discovered, emphasizing the central role of BMPR2 signaling in familial PAH. It was subsequently found that reduced BMPR2 expression and signaling seems to be a feature of other sporadic or idiopathic forms of PAH.

Hypothesizing that increasing BMPR2 signaling might improve PAH, we have performed a High-Throughput Screen of FDA approved drugs to find BMPR2 activators and have identified the immuno-suppressive drug FK506 (Tacrolimus) as as the main activator.
We have subsequently shown that FK506 could rescue endothelial dysfunction in PAH, and prevent and reverse PAH in rodent models of experimental PAH (Spiekerkoetter JCI 2013).

This discovery has lead to the initiation of a phase II clinical trial to test the safety, tolerability and efficacy of low-dose FK506 in PAH at Stanford (http://www.clinicaltrials.gov NCT01647945)

My current research focuses on :
1. Novel ways how to modulate BMPR2 signaling (small molecule HTS screen, identifying novel modifier genes)
2. Evaluating the importance of BMPR2 signaling in the development of Right Ventricular Hypertrophy (RVH) and failure, which is the leading cause of death in PAH (Collaboration with Dres Sushma Reddy and Daniel Bernstein, Pediatric Cardiology, Stanford).
3. Evaluating the importance of BMPR2 signaling in vascular development in neonatal chronic lung disease (Collaboration with Dr. Anne Hilgendorff, Helmholz Institute, Muenchen, Germany).

Publications

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Publication Topics

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