Clinical Focus

• Cardiology
• Cardiovascular genetics
• Hypertrophic Cardiomyopathy
• Heart Failure
• Sports Medicine

Administrative Appointments

• Director, Stanford Center for Inherited Cardiovascular Disease (2010 - present)
• Director, Stanford Hypertrophic Cardiomyopathy Center (2006 - present)
• Director, Stanford Cardiopulmonary Exercise Testing Laboratory (2009 - present)
• Executive Committee, Stanford Cardiovascular Institute (2010 - present)
• Leadership committee, AHA Council on Functional Genomics and Translational Biology (2009 - present)

Honors and Awards

• NIH Director's New Innovator Award, National Institutes of Health (2009)
• Innovative Research Award, American Heart Association (2009)
• Faculty Scholar, Donald E. and Delia B. Baxter Foundation (2009)
• Career Development Award (K08), National Institutes of Health (2006)
• Western Affiliates Young Investigator Award, American Heart Association (2004)

Professional Education

Postdoctoral Advisees

Frederick Dewey , Joshua Knowles , Qiaoyun Shi , Fouad Taghavi , Kathia Zaleta Rivera

Graduate & Fellowship Program Affiliations

• Biomedical Informatics
• Genetics
• Medicine
• Molecular and Genetic Medicine
• Cardiovascular Medicine

Community & International Work

• Arbor Free Cardiology Clinic 

Internet Links

• Ashley Lab website

Current Research Interests

We are interested in the molecular genetics of heart muscle disease. We take an integrative approach, using high dimensional genomic analysis to identify myocardial gene expression networks then use molecular, cellular and physiology tools to assay the biological systems. Our interests range from fit to failing hearts.

Clinical Trials

• Randomized Exercise Study including patients with hypertrophic cardiomyopathy Recruiting

Publications

• Addition of the electrocardiogram to the preparticipation examination of college athletes. Le VV, Wheeler MT, Mandic S, Dewey F, Fonda H, Perez M, Sungar G, Garza D, Ashley EA, Matheson G, Froelicher V. Clin J Sport Med. 2010; 20 (2): 98-105
• Challenges in the clinical application of whole-genome sequencing. Ormond KE, Wheeler MT, Hudgins L, Klein TE, Butte AJ, Altman RB, Ashley EA, Greely HT. Lancet. 2010; 375 (9727): 1749-51
• Chromatin regulation by Brg1 underlies heart muscle development and disease. Hang CT, Yang J, Han P, Cheng HL, Shang C, Ashley E, Zhou B, Chang CP. Nature. 2010; 466 (7302): 62-7
• Clinical assessment incorporating a personal genome. Ashley EA, Butte AJ, Wheeler MT, Chen R, Klein TE, Dewey FE, Dudley JT, Ormond KE, Pavlovic A, Morgan AA, Pushkarev D, Neff NF, Hudgins L, Gong L, Hodges LM, Berlin DS, Thorn CF, Sangkuhl K, Hebert JM, Woon M, Sagreiya H, Whaley R, Knowles JW, Chou MF, Thakuria JV, Rosenbaum AM, Zaranek AW, Church GM, Greely HT, Quake SR, Altman RB. Lancet. 2010; 375 (9725): 1525-35
• Cost-effectiveness of preparticipation screening for prevention of sudden cardiac death in young athletes. Wheeler MT, Heidenreich PA, Froelicher VF, Hlatky MA, Ashley EA. Ann Intern Med. 2010; 152 (5): 276-86