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Paul Utz

Academic Appointments

  • Professor of Medicine (Immunology and Rheumatology)

Key Documents

Contact Information

  • Clinical Offices
    Immunology and Rheumatology Clinic 300 Pasteur Dr A175 MC 5303 Stanford, CA 94305
    Tel Work (650) 723-6961 Fax (650) 725-8418
  • Academic Offices
    Personal Information
    Email Tel (650) 724-5421
    Alternate Contact
    Sharon Dickow Administrative Assistant Tel Work 723-7038
    Not for medical emergencies or patient use

Professional Overview

Bio

While earning his M.D. degree in 1991 from Stanford, Dr. Utz co-discovered the transcription factor Nuclear Factor of Activated T Cells (NFAT) with J.P. Shaw in Dr. Gerald Crabtree's laboratory. He completed his internal medicine residency, rheumatology fellowship, and post-doctoral training at Brigham and Women's Hospital in Boston prior to joining the Harvard Medical School Faculty in 1996. He joined the Stanford Faculty in 1999 and was promoted to Associate Professor of Medicine in 2005 and Professor in 2012. Professor Utz is an expert in the study of human and murine autoantibodies and autoantigens, apoptosis signaling pathways, animal models of autoimmunity, proteomics and multiplexed assay development for biomarker discovery.

Clinical Focus

  • Immunology and Rheumatology
  • Rheumatology

Academic Appointments

Administrative Appointments

  • Program Director, Medical Science Training Program (MSTP)., Stanford University School of Medicine (2013 - present)
  • Program Director, Rheumatology Fellowship Program., Stanford University School of Medicine (2012 - 2013)
  • MSTP Associate Director, Medical Science Training Program, Stanford University School of Medicine (2009 - 2013)
  • Member, Committee on Professionalism, Performance, and Promotion, Stanford University School of Medicine (2009 - present)
  • Associate Director of Education, Stanford University, ITI Institute (2007 - present)
  • Member, Cardiovascular Institute Steering Committee, Stanford University School of Medicine (2007 - 2010)
View All 15administrative appointments of Paul Utz

Honors and Awards

  • Elected Member, American Society for Clinical Investigation (2007)
  • Elected Member, The Kunkel Society (2006)
  • Divisional Teaching Award, Stanford University (2002)
  • Department of Medicine Teaching Award, Stanford University School of Medicine (2008)
  • Baxter Fellowship, Donald and Delia Baxter (2000)
  • Faculty Fellows Program, Stanford University School of Medicine (2009)
View All 22honors and awards of Paul Utz

Professional Education

Fellowship: Brigham and Women's Hospital Harvard Medical School MA (1996)
Residency: Brigham and Women's Hospital Harvard Medical School MA (1993)
Internship: Brigham and Women's Hospital Harvard Medical School MA (1992)
Board Certification: Rheumatology, American Board of Internal Medicine (1996)
Medical Education: Stanford University School of Medicine CA (1991)
M.D.: Stanford University, Medicine (1991)
View All 7

Community and International Work

Courses

2013-14

Prior Year Coursescourses of Paul Utz

Postdoctoral Advisees

David HaddonJen-Hao Kuo

Scientific Focus

Current Research and Scholarly Interests

Members of his laboratory are developing several cutting-edge proteomics technologies for immunological applications, including multiplex planar-based autoantigen microarrays for studying lupus, multiple sclerosis, and other diseases such as diabetes and MCTD; reverse phase protein lysate microarrays for studying blood cells; flow-based assays for analyzing samples from patients; and microfluidic capillary electrophoresis assays. Professor Utz is Founder and Faculty Director of the SIMR Summer High School Research Program, retired Chair of Education for the Federation of Clinical Immunology Societies, and assumed the role of Director of Stanford's Medical Scientist Training Program (MSTP) in August 2013. He provides formal lectures to undergraduate, graduate, and medical students in the Schools of Medicine and Engineering. He also teaches medical students, residents and fellows in the clinics and on the in-patient wards, and has won teaching awards in immunology and in medicine. Professor Utz is a member of the Scientific Advisory Boards of several biotechnology and pharmaceutical companies, and has cofounded 3 Bay Area companies.

The four major goals of our studies are:

(1) To understand the mechanisms by which highly-conserved, diverse molecules and complexes such as histones and splicing particles are targeted by T and B lymphocytes and to determine how an immune response directed against ubiquitous antigens leads to organ-specific autoimmune disease.

(2) To use autoimmune sera as molecular probes to study basic cellular processes, particularly apoptosis signaling pathways, alternative RNA splicing, and endoplasmic reticulum protein transport.

(3) To invent and validate novel technologies for high-throughput, multiplex proteomics signaling molecules and studies. We are currently focusing on proteomics analysis of proteins secreted by immune cells, including cytokines and autoantibodies.

(4) To take advantage of the information provided by autoantibody profiling methods to develop antigen-specific tolerizing therapies for common autoimmune diseases. We collaborate closely with the Stanford laboratory of Dr. Larry Steinman, the principle discoverer of DNA tolerizing technology. Our long-term goal is to develop patient-specific, individualized therapeutics.

Publications

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Publication Topics

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