Upinder Singh
Academic Appointments
- Associate Professor, Medicine - Infectious Diseases
- Member, Bio-X
- Associate Professor, Microbiology & Immunology
Key Documents
Contact Information
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Clinical Offices
Infectious Disease Clinic 300 Pasteur Dr Lane Bldg Rm L-136 Stanford, CA 94305 Tel Work (650) 723-6961 Fax (650) 725-8418
- Academic Offices
Personal Information Email Tel (650) 723-4045Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Infectious Disease
- Infectious Diseases
Administrative Appointments
- Division Chief, Infectious Diseases and Geographic Medicine (2010 - present)
- Fellowship Co-Director, Division of Infectious Diseases (2008 - present)
Honors and Awards
- Member, ASCI (2010)
Professional Education
| Fellowship: | University of Virginia School of Medicine VA (1998) |
| Internship: | University of Virginia Health System VA (1993) |
| Medical Education: | Ohio State University OH (1992) |
| BS: | Ohio State University, Biochemistry (1987) |
| MD: | Ohio State University, Medicine (1992) |
Postdoctoral Advisees
Sean Collins, Bardees Foda, Lily Horng, Amanda Kamali, Shanthi Kappagoda, Dipak Manna, George Melikian, Eva Mortensen, John Openshaw, Venkata Raveendra Pothineni, Eugene Richardson, Harleen Sahni, Madeline Slater, Elizabeth Soda, Paul Waldron, Stanley Wang
Graduate & Fellowship Program Affiliations
Community and International Work
- Investigating E. histolytica genetic diversity, Bangladesh and Georgia
Internet Links
Scientific Focus
Current Research Interests
Dr Singh studies the molecular basis of pathogenesis of a medically important parasite, Entamoeba histolytica. The work is aimed at understanding the virulence determinants that E. histolytica utilizes in causing invasive colonic and hepatic disease. Using a combination of genetic and genomic approaches we are identifying novel mechanisms that the parasite has developed for invading the human host. Additionally, we study the epidemiological trends of of amebic infection, with the goal of identifying a parasite molecular signature that correlates with invasive potential.
Publications
- Nucleus-localized antisense small RNAs with 5'-polyphosphate termini regulate long term transcriptional gene silencing in Entamoeba histolytica G3 strain. J Biol Chem. 2011; (52): 44467-79
- An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion. Genes Dev. 2008; (12): 1636-46
- Small RNAs with 5'-polyphosphate termini associate with a Piwi-related protein and regulate gene expression in the single-celled eukaryote Entamoeba histolytica. PLoS Pathog. 2008; (11): e1000219
- Distinct distal gut microbiome diversity and composition in healthy children from Bangladesh and the United States. PLoS One. 2013; (1): e53838
- Regulation of H2O2 stress-responsive genes through a novel transcription factor in the protozoan pathogen Entamoeba histolytica. J Biol Chem. 2013; (6): 4462-74
- A detoxifying oxygen reductase in the anaerobic protozoan Entamoeba histolytica. Eukaryot Cell. 2012; (9): 1112-8
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