Stephen Galli
Academic Appointments
- Professor, Pathology
- Member, Bio-X
- Member, Stanford Cancer Institute
- Professor, Microbiology & Immunology
Key Documents
Contact Information
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Clinical Offices
Department of Pathology 300 Pasteur Dr L235 MC 5324 Stanford, CA 94305 Tel Work (650) 723-7975 Fax (650) 723-9435Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information Email Tel (650) 723-7975Alternate Contact Rochelle Roberts Administrative Assistant Email Tel Work 650-723-7975Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Pathology
- Pathology and Laboratory Medicine
Administrative Appointments
- Chair, Stanford University School of Medicine - Pathology (1999 - present)
Professional Education
| Medical Education: | Harvard Medical School MA (1973) |
| Residency: | Massachusetts General Hospital MA (1977) |
Postdoctoral Advisees
Nicolas Gaudenzio, Thomas Marichal, Laurent Reber, Riccardo Sibilano, Philipp Starkl
Internet Links
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information
Scientific Focus
Current Research Interests
Mast cells, which normally reside in the tissues, and basophils, which circulate in the blood, are major effector cells of asthma and other IgE-associated allergic disorders and immune responses to parasites. However, mast cells also have been implicated (as effector and/or immunoregulatory cells) in many other settings, including certain autoimmune or inflammatory disorders, innate immune responses to pathogens and resistance to exogenous and exogenous agents which can express significant toxicity; mast cells also may contribute importantly, in certain settings, to angiogenesis, the regulation of epithelial development and function and fibrosis and other examples of tissue remodeling.
The goals of Dr. Gallis laboratory are to develop and employ genetic approaches in mice to understand the regulation of mast cell and basophil development and the expression of mast cell and basophil function, and to elucidate the roles of these cells in health and disease. In parallel with these mouse studies, we investigate the roles of mast cells in human health and disease by conducting studies of human mast cells, or by analyzing specimens derived from patients with asthma or other disorders in which mast cell have been implicated.
Publications
- Evidence that mast cells are not required for healing of splinted cutaneous excisional wounds in mice. PLoS One. 2013; (3): e59167
- Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice. J Allergy Clin Immunol. 2013; (2): 541-8.e1-9
- PLA2G3 promotes mast cell maturation and function. Nat Immunol. 2013; (6): 527-9
- Critical role of P1-Runx1 in mouse basophil development. Blood. 2012; (1): 76-85
- Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice. Lab Invest. 2012; (10): 1472-82
- IgE and mast cells in allergic disease. Nat Med. 2012; (5): 693-704
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