Biography
Dr. Wu also conduct research in cardiac developmental biology/congenital heart disease, stem cell biology and translation of stem cells into new treatments for congenital heart disease, adult heart failure and rhythm disorders.
In addition to completion of residency program and board certification in internal medicine, Dr. Wu has also completed a 3-year ACGME-accredited fellowship in cardiovascular disease with board certification and additional clinical training in echocardiography at Massachusetts General Hospital and cardiac developmental biology research training at Boston Children's Hospital/Harvard Medical School in Boston, MA.
Professional Summary
Education & Certifications
- Board Certification: American Board of Internal Medicine, Cardiovascular Disease (2016)
- Research Fellowship, Boston Children's Hospital/Harvard Medical School, Stem Cell Biology (2006)
- Fellowship: Massachusetts General Hospital (2005) MA
- Board Certification, Internal Medicine, ABIM (2003)
- Residency: Duke University Medical Center (2001) NC
- Medical Education: Duke University School of Medicine (1999) NC
- PhD, Duke University School of Arts and Sciences, Pathology (1998)
- BS, Stanford University, Mechanical Engineering (1992)
- BS, Stanford University, Biological Science (1992)
Honors & Awards
- 2018 Kenneth D. Bloch Memorial Lecturer in Vascular Biology, American Heart Association (2018)
- Abstract of Distinction, Research Symposium - Massachusetts General Hospital (2005)
- ACCF/Bristol Meyers Travel Award, American College of Cardiology (2002)
- Award for Academic Excellence and Achievement, American Society of Clinical Pathologists (1996, 1997)
- Cardiovascular Medicine Division Teaching Award, Department of Medicine, Stanford University School of Medicine (2015)
- Career Development Award in Cardiovascular Medicine, American College of Cardiology Foundation/Pfizer (2004-2007)
- Consulting Editors of the Year, Circulation Research (2018)
- David Lawrence Stein Award, American Heart Association-Western Affiliate (2014)
- de Gunzburg Family Scholar, Massachusetts General Hospital (2006)
- Distinguished Achievement Award, Basic Cardiovascular Sciences Council, American Heart Association (2022)
- Elected Member, American Society for Clinical Investigation (ASCI) (2016)
- Elected Member, Association of American Physicians (AAP) (2024)
- Elected Member, Association of University Cardiologists (AUC) (2023)
- Endowed Faculty Scholar, Child Health Research Institute/ Lucile Packard Foundation for Children's Health (2013-2018)
- Established Investigator Award, American Heart Association (2017-2021)
- Experimental Pathologist-in-Training, American Society for Investigative Pathology (1998)
- Fellow, American College of Cardiology (2010)
- Henry Christian Award for Research Excellence, American Federation for Medical Research (1999)
- Joan and Sanford I. Weill Scholar, Stanford Cardiovascular Institute (2020-)
- K08 Mentored Clinical Scientist Award, NIH/NHLBI (2005-2011)
- Merck/ACC Young Investigator Award - 2nd Place, American College of Cardiology (2001)
- NIH Director's New Innovator Award, National Institutes of Health, Office of the Director (2008-2013)
- NIH Director's Pioneer Award, National Institutes of Health, Office of the Director (2014-2019)
- NIH/NHLBI Scholarship, Keystone Symposium on Molecular Mechanism of Cardiac Disease and Regeneration (2005)
- President's Award for Academic Excellence, Stanford University (1989)
- Progenitor Cell Biology Consortium, Co-Principal Investigator, NIH/NHLBI (2009-2016)
- Seed Grant Award (Co-Recipient with Dr. Beth Pruitt), Stanford Cardiovascular Institute (2013-2014)
- Seed Grant Recipient, Harvard Stem Cell Institute (2008-2010)
- SPARK Research Award, Division of Cardiology, Massachusetts General Hospital (2010-2011)
- Superior Editorial Consultant, Circulation Research (2017)
- Tau Beta Pi, Stanford University School of Engineering (1992)
- Terman Award, Stanford University School of Engineering (1992)
- Young Investigator Competitive Award in Cardiovascular Medicine, GlaxoSmithKline Education and Research Foundation (2007-2009)
Memberships
- Chair-Elect, AHA Basic Cardiovascular Sciences Council (2024 - Present)
- Chair, Scientific Committee, Sarnoff Cardiovascular Research Foundation (2023 - Present)
- Member, AHA-Council Operations Committee (2022 - Present)
- Member, Scientific Advisory Board, Cardiovascular Research Institute, Mt Sinai School of Medicine (2022 - Present)
- President, Board of Directors, American Heart Association Bay Area Division (2022 - Present)
- Immediate-Past Chair, AHA-BCVS Committee on Early Career Development (2022 - 2024)
- Vice Chair, Scientific Committee, Sarnoff Cardiovascular Research Foundation (2022 - 2023)
- President-Elect, Board of Directors, American Heart Association Bay Area Division (2021 - 2022)
- Member, Scientific Committee, Sarnoff Cardiovascular Research Foundation (2020 - Present)
- Chair, American Heart Association National Research Committee, Bioethics Subcommittee (2020 - 2022)
- Chair, AHA-BCVS Committee on Early Career Development (2020 - 2022)
- Vice Chair, AHA-BCVS Committee on Early Career Development (2018 - 2020)
- Vice-Chair, American Heart Association National Research Committee, Bioethics Subcommittee (2017 - 2020)
- Member, AHA - Committee on Scientific Session Programming (CSSP) (2016 - 2020)
- Member, AHA - BCVS Committee on Scientific and Clinical Education Lifelong Learning Committee (2016 - 2020)
- Member, American Heart Association - BCVS Committee on Early Career Development (2015 - 2018)
- Member, American Heart Association National Research Committee, Stem Cell Research Subgroup (2013 - 2017)
- Member, American Heart Association National Stem Cell Therapy Writing Group (2012 - 2014)
- Member, Research Administration Advisory Committee, Massachusette General Hospital (2010 - 2012)
Administrative Appointments
- Assistant Physician, Massachusetts General Hospital (2009 - 2012)
- Assistant Professor of Medicine, Harvard Medical School (2009 - 2012)
- Assistant Professor of Medicine, Stanford University, School of Medicine (2012 - 2015)
- Associate Editor, BMC Cardiovascular Disease (2011 - 2014)
- Associate Member, Stanford Diabetes Research Center (2017 - Present)
- Associate Professor of Medicine (with tenure) and (by courtesy) Pediatrics, Stanford University (2016 - 2022)
- Chair, Faculty Search Committee, Basic Sci & Enginr (BASE) Program, Moore Heart Center, LPCH (2018 - 2019)
- Chair, Faculty Search Committee, Surgical & Basic Science Faculty, Dept. of Cardiothoracic Surgery, Stanford SoM (2020 - Present)
- Co-Chair, Faculty Search Committee, Basic Sci & Enginr (BASE) Program, Moore Heart Center, LPCH (2021 - Present)
- Consulting Editor, Circulation Research (2015 - 2019)
- Director, Mouse Microinjection Core, Massachusetts General Hospital (2007 - 2012)
- Editor-in-Chief, Current Treatment Options in Cardiovascular Medicine (2022 - Present)
- Editorial Board, Clinical Medicine Insights: Cardiology (2007 - 2012)
- Editorial Board, World Journal of Stem Cell (2009 - 2012)
- Editorial Board, Frontiers in Pharmacology and Smooth Muscle Biology (2010 - 2013)
- Editorial Board - General, Circulation Research (2014 - Present)
- Editorial Consultant, Journal of American College of Cardiology: Basic to Translational Science (2015 - Present)
- Guest Editor, Journal of Cardiovascular Development and Differentiation (2015 - 2016)
- Instructor in Medicine, Harvard Medical School (2006 - 2009)
- Member, Editorial Board, Cardiology Discovery (2020 - Present)
- Member, Editorial Board, Journal of Cardiovascular Development and Disease (2021 - Present)
- Organizing Committee, NIH/NHLBI Cardiovascular Regenerative Medicine Symposium (2011 - 2013)
- Professor of Medicine and (by courtesy) Pediatrics, Stanford University (2022 - Present)
- Section Chief, Basic and Translational Research, Cardiovascular Medicine Division, Department of Medicine (2021 - Present)
- Section Editor, Current Treatment Options in Cardiovascular Medicine (2013 - 2017)
- Section Editor, Current Cardiology Reports (2016 - Present)
- Senior Vice Chair (Interim) for Academic Affairs, Department of Medicine, Stanford University School of Medicine (2022 - 2023)
- Vice Chair for Academic Affairs, Department of Medicine, Stanford University School of Medicine (2023 - Present)
Publications
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Mechanism of hypochlorite-mediated inactivation of proteinase inhibition by alpha(2)-Macroglobulin
Wu, S. M., & Pizzo, S. V. (1999). Mechanism of hypochlorite-mediated inactivation of proteinase inhibition by alpha(2)-Macroglobulin. BIOCHEMISTRY, 38(42), 13983–13990. -
The conformation-dependent interaction of alpha(2)-macroglobulin with vascular endothelial growth factor - A novel mechanism of alpha(2)-macroglobulin/growth factor binding
Bhattacharjee, G., Asplin, I. R., Wu, S. M., Gawdi, G., & Pizzo, S. V. (2000). The conformation-dependent interaction of alpha(2)-macroglobulin with vascular endothelial growth factor - A novel mechanism of alpha(2)-macroglobulin/growth factor binding. JOURNAL OF BIOLOGICAL CHEMISTRY, 275(35), 26806–26811. -
Differential regulation of the fibroblast growth factor (FGF) family by alpha(2)-macroglobulin: evidence for selective modulation of FGF-2-induced angiogenesis
Asplin, I. R., Wu, S. M., Mathew, S., Bhattacharjee, G., & Pizzo, S. V. (2001). Differential regulation of the fibroblast growth factor (FGF) family by alpha(2)-macroglobulin: evidence for selective modulation of FGF-2-induced angiogenesis. BLOOD, 97(11), 3450–3457. -
alpha(2)-Macraglobulin from rheumatoid arthritis synovial fluid: Functional analysis defines a role for oxidation in inflammation
Wu, S. M., & Pizzo, S. V. (2001). alpha(2)-Macraglobulin from rheumatoid arthritis synovial fluid: Functional analysis defines a role for oxidation in inflammation. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 391(1), 119–126. -
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart
Wu, S. M., Fujiwara, Y., Cibulsky, S. M., Clapham, D. E., Lien, C.-ling, Schultheiss, T. M., & Orkin, S. H. (2006). Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. CELL, 127(6), 1137–1150. -
Origins and fates of cardiovascular progenitor cells
Wu, S. M., Chien, K. R., & Mummery, C. (2008). Origins and fates of cardiovascular progenitor cells. CELL, 132(4), 537–43. -
Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart
Zhou, B., Ma, Q., Rajagopal, S., Wu, S. M., Domian, I., Rivera-Feliciano, J., … Pu, W. T. (2008). Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. NATURE, 454(7200), 109–U5. -
Mesp1 at the heart of mesoderm lineage specification
Wu, S. M. (2008). Mesp1 at the heart of mesoderm lineage specification. CELL STEM CELL, 3(1), 1–2. -
VISIONS: the art of science.
Wu, S. M. (2009). VISIONS: the art of science. Molecular Reproduction and Development, 76(6), 525-? -
Generation of Functional Ventricular Heart Muscle from Mouse Ventricular Progenitor Cells
Domian, I. J., Chiravuri, M. U., van der Meer, P., Feinberg, A. W., Shi, X., Shao, Y., … Chien, K. R. (2009). Generation of Functional Ventricular Heart Muscle from Mouse Ventricular Progenitor Cells. SCIENCE, 326(5951), 426–29. -
Cardiovascular Stem Cells in Regenerative Medicine: Ready for Prime Time?
Liu, Y.-H., Karra, R., & Wu, S. M. (2008). Cardiovascular Stem Cells in Regenerative Medicine: Ready for Prime Time? Drug Discovery Today. Therapeutic Strategies, 5(4), 201–7. -
Isolation and functional characterization of pluripotent stem cell-derived cardiac progenitor cells.
Huang, X., & Wu, S. M. (2010). Isolation and functional characterization of pluripotent stem cell-derived cardiac progenitor cells. Current Protocols in Stem Cell Biology, Chapter 1, Unit 1F 10-? -
Promises and pitfalls in cell replacement therapy for heart failure.
Krane, M., Wernet, O., & Wu, S. M. (2010). Promises and pitfalls in cell replacement therapy for heart failure. Drug Discovery Today. Disease Mechanisms, 7(2), e109–e115. -
Developmental and Regenerative Biology of Multipotent Cardiovascular Progenitor Cells
Sturzu, A. C., & Wu, S. M. (2011). Developmental and Regenerative Biology of Multipotent Cardiovascular Progenitor Cells. CIRCULATION RESEARCH, 108(3), 353–64. -
Harnessing the potential of induced pluripotent stem cells for regenerative medicine
Wu, S. M., & Hothedlinger, K. (2011). Harnessing the potential of induced pluripotent stem cells for regenerative medicine. NATURE CELL BIOLOGY, 13(5), 497–505. -
Epigenetic mechanisms in cardiac development and disease
Vallaster, M., Vallaster, C. D., & Wu, S. M. (2012). Epigenetic mechanisms in cardiac development and disease. ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 44(1), 92–102. -
Reprogramming of mouse, rat, pig, and human fibroblasts into iPS cells.
Rajarajan, K., Engels, M. C., & Wu, S. M. (2012). Reprogramming of mouse, rat, pig, and human fibroblasts into iPS cells. Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.], Chapter 23, Unit 23 15-? -
Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5
Chen, J. X., Krane, M., Deutsch, M.-A., Wang, L., Rav-Acha, M., Gregoire, S., … Wu, S. M. (2012). Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5. CIRCULATION RESEARCH, 111(1), 50–55. -
Reprogramming the Beat Kicking It Up a Notch
Wu, S. M., & Milan, D. J. (2012). Reprogramming the Beat Kicking It Up a Notch. CIRCULATION, 126(9), 1009–1011. -
Early cardiac development: a view from stem cells to embryos
van Vliet, P., Wu, S. M., Zaffran, S., & Puceat, M. (2012). Early cardiac development: a view from stem cells to embryos. CARDIOVASCULAR RESEARCH, 96(3), 352–362. -
iPS Cell Modeling of Cardiometabolic Diseases
Nakamura, K., Hirano, K.-ichi, & Wu, S. M. (2013). iPS Cell Modeling of Cardiometabolic Diseases. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH, 6(1), 46–53. -
Essential and Unexpected Role of Yin Yang 1 to Promote Mesodermal Cardiac Differentiation
Gregoire, S., Karra, R., Passer, D., Deutsch, M.-A., Krane, M., Feistritzer, R., … Wu, S. M. (2013). Essential and Unexpected Role of Yin Yang 1 to Promote Mesodermal Cardiac Differentiation. CIRCULATION RESEARCH, 112(6), 900–U104. -
Autophagy - the friendly fire in endothelial cell regeneration. Focus on "Autophagy in endothelial progenitor cells is cytoprotective in hypoxic conditions"
Sharma, A., & Wu, S. M. (2013). Autophagy - the friendly fire in endothelial cell regeneration. Focus on "Autophagy in endothelial progenitor cells is cytoprotective in hypoxic conditions". AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 304(7), C614–C616. -
Of fish and men: clonal lineage analysis identifies divergence in myocardial development.
Sharma, A., & Wu, S. M. (2013). Of fish and men: clonal lineage analysis identifies divergence in myocardial development. Circulation Research, 112(4), 583–85. -
At a Crossroad Cell Therapy for Cardiac Repair
Deutsch, M.-A., Sturzu, A., & Wu, S. M. (2013). At a Crossroad Cell Therapy for Cardiac Repair. CIRCULATION RESEARCH, 112(6), 884–90. -
Low-density lipoprotein receptor-related protein alpha(2)-macroglobulin receptor on murine peritoneal macrophages mediates the binding and catabolism of low-density lipoprotein
Wu, S. M., & Pizzo, S. V. (1996). Low-density lipoprotein receptor-related protein alpha(2)-macroglobulin receptor on murine peritoneal macrophages mediates the binding and catabolism of low-density lipoprotein. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 326(1), 39–47. -
The binding of receptor-recognized alpha(2)-macroglobulin to the low density lipoprotein receptor-related protein and the alpha(2)M signaling receptor is decoupled by oxidation
Wu, S. M., BOYER, C. M., & Pizzo, S. V. (1997). The binding of receptor-recognized alpha(2)-macroglobulin to the low density lipoprotein receptor-related protein and the alpha(2)M signaling receptor is decoupled by oxidation. JOURNAL OF BIOLOGICAL CHEMISTRY, 272(33), 20627–20635. -
Oxidized alpha(2)-macroglobulin (alpha(2)M) differentially regulates receptor binding by cytokines growth factors: Implications for tissue injury and repair mechanisms in inflammation
Wu, S. M., Patel, D. D., & Pizzo, S. V. (1998). Oxidized alpha(2)-macroglobulin (alpha(2)M) differentially regulates receptor binding by cytokines growth factors: Implications for tissue injury and repair mechanisms in inflammation. JOURNAL OF IMMUNOLOGY, 161(8), 4356–4365. -
Platypnea-orthodeoxia syndrome in two previously healthy adults: a case-based review
Platypnea-orthodeoxia syndrome in two previously healthy adults: a case-based review. (2009). Clinical Medicine Insights: Cardiology, 3. -
Regenerative strategies for cardiac disease
Regenerative strategies for cardiac disease. (2011). In: Stem Cells and Regenerative Medicine. Humana Press., 1. -
A Brief Primer on the Development of the Heart
A Brief Primer on the Development of the Heart. (2012). Heart Failure, 2nd Ed. -
Crashing the Boards: A User Friendly Study Guide for the USMLE Step 1
Crashing the Boards: A User Friendly Study Guide for the USMLE Step 1. (1997). Lippincott-Raven, 1. -
a-Macroglobulins/Kunins
a-Macroglobulins/Kunins. (2000). In: Hemostasis and Thrombosis: Basic Principles and Clinical Practice, 4th Ed. -
Cardiac progenitor cells: from embryonic to the aging heart.
Cardiac progenitor cells: from embryonic to the aging heart. (2010). Aging Health, 6(6). -
Putting the Pieces Together: Stem Cells and The Quest to Heal A Broken Heart
Wu, S. M., & Singh, J. P. (2012). Putting the Pieces Together: Stem Cells and The Quest to Heal A Broken Heart. CardioSource World News, 12. -
Multipotent stem cells in cardiac regenerative therapy
Karra, R., & Wu, S. M. (2008). Multipotent stem cells in cardiac regenerative therapy. REGENERATIVE MEDICINE, 3(2), 189–198. -
Small molecule regulators of postnatal Nkx2.5 cardiomyoblast proliferation and differentiation
Chen, W.-P., & Wu, S. M. (2012). Small molecule regulators of postnatal Nkx2.5 cardiomyoblast proliferation and differentiation. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 16(5), 961–965. -
Screening drug-induced arrhythmia events using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays.
Navarrete, E. G., Liang, P., Lan, F., Sanchez-Freire, V., Simmons, C., Gong, T., … Wu, J. C. (2013). Screening drug-induced arrhythmia events using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation, 128(11), S3–13. -
Derivation and Functional Characterization of Nkx2.5+Cardiac Progenitor Cells from Mouse Induced Pluripotent Stem Cells
Pijnappels, D. A., Stadtfeld, M., Zeng, M., Yu, E., Fujiwara, Y., Wang, G., … Wu, S. M. (2008). Derivation and Functional Characterization of Nkx2.5+Cardiac Progenitor Cells from Mouse Induced Pluripotent Stem Cells. CIRCULATION, 118(18), S428–S428. -
Committed Ventricular Progenitors in the Islet-1 Lineage Expand and Assemble Into Functional Ventricular Heart Muscle
van der Meer, P., Domian, I. J., Chiravuri, M. U., Feinberg, A. F., Wu, S. M., Parker, K. K., & Chien, K. R. (2009). Committed Ventricular Progenitors in the Islet-1 Lineage Expand and Assemble Into Functional Ventricular Heart Muscle. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 53(10), A468–A468. -
Myocardial Injury Induces the Expansion and Cardiomyogenic Differentiation of Postnatal Nkx2.5 Progenitor Cells via Inflammatory Signals
Liu, Y.-H., Rawnsley, D., Zeng, M., Yu, E., Pijnappels, D., Thibault, H., … Wu, S. M. (2009). Myocardial Injury Induces the Expansion and Cardiomyogenic Differentiation of Postnatal Nkx2.5 Progenitor Cells via Inflammatory Signals. CIRCULATION, 120(18), S756–S756. -
A83-01, a TGF beta RI inhibitor, can proliferate adult cardiac progenitor cells and improve cardiac contractility of myocardial infarcted mice
Chen, W.-P., Liu, Y.-H., Ho, Y.-J., & Wu, S. M. (2013). A83-01, a TGF beta RI inhibitor, can proliferate adult cardiac progenitor cells and improve cardiac contractility of myocardial infarcted mice. ACTA PHARMACOLOGICA SINICA. -
Origin of Cardiac Progenitor Cells in the Developing and Postnatal Heart
Kuhn, E. N., & Wu, S. M. (2010). Origin of Cardiac Progenitor Cells in the Developing and Postnatal Heart. JOURNAL OF CELLULAR PHYSIOLOGY, 225(2), 321–325. -
Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening
Sharma, A., Wu, J. C., & Wu, S. M. (2013). Induced pluripotent stem cell-derived cardiomyocytes for cardiovascular disease modeling and drug screening. STEM CELL RESEARCH & THERAPY, 4. -
Telocytes in human heart valves
Yang, Y., Sun, W., Wu, S. M., Xiao, J., & Kong, X. (2014). Telocytes in human heart valves. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 18(5), 759–65. -
Meta-Analysis of Stem Cell Therapy in Chronic Ischemic Cardiomyopathy
Kandala, J., Upadhyay, G. A., Pokushalov, E., Wu, S., Drachman, D. E., & Singh, J. P. (2013). Meta-Analysis of Stem Cell Therapy in Chronic Ischemic Cardiomyopathy. AMERICAN JOURNAL OF CARDIOLOGY, 112(2), 217–25. -
Induced pluripotent stem cell modeling of complex genetic diseases.
Hinson, J. T., Nakamura, K., & Wu, S. M. (2012). Induced pluripotent stem cell modeling of complex genetic diseases. Drug Discovery Today. Disease Models, 9(4), e147–e152. -
Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm.
Engels, M. C., Rajarajan, K., Feistritzer, R., Sharma, A., Nielsen, U. B., Schalij, M. J., … Wu, S. M. (2014). Insulin-like growth factor promotes cardiac lineage induction in vitro by selective expansion of early mesoderm. Stem Cells , 32(6), 1493–1502. -
Somatic Cell Reprogramming into Cardiovascular Lineages
Chen, J. X., Plonowska, K., & Wu, S. M. (2014). Somatic Cell Reprogramming into Cardiovascular Lineages. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS, 19(4), 340–49. -
Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus b3-induced myocarditis and antiviral drug screening platform.
Sharma, A., Marceau, C., Hamaguchi, R., Burridge, P. W., Rajarajan, K., Churko, J. M., … Wu, J. C. (2014). Human induced pluripotent stem cell-derived cardiomyocytes as an in vitro model for coxsackievirus b3-induced myocarditis and antiviral drug screening platform. Circulation Research, 115(6), 556–66. -
Patching Up Broken Hearts: Cardiac Cell Therapy Gets a Bioengineered Boost
Serpooshan, V., & Wu, S. M. (2014). Patching Up Broken Hearts: Cardiac Cell Therapy Gets a Bioengineered Boost. Cell Stem Cell, 15(6), 671–73. -
Patching up broken hearts: cardiac cell therapy gets a bioengineered boost.
Serpooshan, V., & Wu, S. M. (2014). Patching up broken hearts: cardiac cell therapy gets a bioengineered boost. Cell Stem Cell, 15(6), 671–73. -
Pharmacological inhibition of TGFß receptor improves Nkx2.5 cardiomyoblast-mediated regeneration.
Chen, W.-P., Liu, Y.-H., Ho, Y.-J., & Wu, S. M. (2015). Pharmacological inhibition of TGFß receptor improves Nkx2.5 cardiomyoblast-mediated regeneration. Cardiovascular Research, 105(1), 44–54. -
Molecular Regulation of Cardiomyocyte Differentiation
Paige, S. L., Plonowska, K., Xu, A., & Wu, S. M. (2015). Molecular Regulation of Cardiomyocyte Differentiation. CIRCULATION RESEARCH, 116(2), 341–53. -
Identification of cardiovascular lineage descendants at single-cell resolution.
Li, G., Plonowska, K., Kuppusamy, R., Sturzu, A., & Wu, S. M. (2015). Identification of cardiovascular lineage descendants at single-cell resolution. Development , 142(5), 846–57. -
Small RNAs make big impact in cardiac repair.
Krane, M., Deutsch, M.-A., Doppler, S., Lange, R., & Wu, S. M. (2015). Small RNAs make big impact in cardiac repair. Circulation Research, 116(3), 393–95. -
Comparing mouse and human pluripotentstem cell derived cardiac cells: both systemshave advantages for pharmacological and toxicological screening.
Lagerqvist, E. L., Finnin, B. A., Elliott, D., Anderson, D., Wu, S. M., Pouton, C. W., & Haynes, J. M. (2015). Comparing mouse and human pluripotentstem cell derived cardiac cells: both systemshave advantages for pharmacological and toxicological screening. Journal of Pharmacological and Toxicological Methods. -
Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss.
Sturzu, A. C., Rajarajan, K., Passer, D., Plonowska, K., Riley, A., Tan, T. C., … Wu, S. M. (2015). Fetal Mammalian Heart Generates a Robust Compensatory Response to Cell Loss. Circulation, 132(2), 109–21. -
Harnessing the Induction of Cardiomyocyte Proliferation for Cardiac Regenerative Medicine.
Sharma, A., Zhang, Y., & Wu, S. M. (2015). Harnessing the Induction of Cardiomyocyte Proliferation for Cardiac Regenerative Medicine. Current Treatment Options in Cardiovascular Medicine, 17(10), 404-? -
Members Only: Hypoxia-Induced Cell-Cycle Activation in Cardiomyocytes.
Sharma, A., & Wu, S. M. (2015). Members Only: Hypoxia-Induced Cell-Cycle Activation in Cardiomyocytes. Cell Metabolism, 22(3), 365–66. -
Cardioprotective Actions of TGF beta RI Inhibition Through Stimulating Autocrine/Paracrine of Survivin and Inhibiting Wnt in Cardiac Progenitors
Ho, Y.-S., Tsai, W.-H., Lin, F.-C., Huang, W.-P., Lin, L.-C., Wu, S. M., … Chen, W.-P. (2016). Cardioprotective Actions of TGF beta RI Inhibition Through Stimulating Autocrine/Paracrine of Survivin and Inhibiting Wnt in Cardiac Progenitors. STEM CELLS, 34(2), 445–55. -
Integrin Based Isolation Enables Purification of Murine Lineage Committed Cardiomyocytes
Tarnawski, L., Xian, X., Monnerat, G., Macaulay, I. C., Malan, D., Borgman, A., … Jovinge, S. (2015). Integrin Based Isolation Enables Purification of Murine Lineage Committed Cardiomyocytes. PLOS ONE, 10(8). -
Myeloid zinc finger 1 (mzf1) differentially modulates murine cardiogenesis by interacting with an nkx2.5 cardiac enhancer.
Doppler, S. A., Werner, A., Barz, M., Lahm, H., Deutsch, M.-A., Dreßen, M., … Krane, M. (2014). Myeloid zinc finger 1 (mzf1) differentially modulates murine cardiogenesis by interacting with an nkx2.5 cardiac enhancer. PloS One, 9(12), e113775. -
Lift NIH restrictions on chimera research.
Sharma, A., Sebastiano, V., Scott, C. T., Magnus, D., Koyano-Nakagawa, N., Garry, D. J., … Wu, S. M. (2015). Lift NIH restrictions on chimera research. Science (New York, N.Y.), 350(6261), 640. -
Regenerative Medicine: Potential Mechanisms of Cardiac Recovery in Takotsubo Cardiomyopathy.
Chang, A. Y., Kittle, J. T., & Wu, S. M. (2016). Regenerative Medicine: Potential Mechanisms of Cardiac Recovery in Takotsubo Cardiomyopathy. Current Treatment Options in Cardiovascular Medicine, 18(3), 20-? -
Derivation of Highly Purified Cardiomyocytes from Human Induced Pluripotent Stem Cells Using Small Molecule-modulated Differentiation and Subsequent Glucose Starvation.
Sharma, A., Li, G., Rajarajan, K., Hamaguchi, R., Burridge, P. W., & Wu, S. M. (2015). Derivation of Highly Purified Cardiomyocytes from Human Induced Pluripotent Stem Cells Using Small Molecule-modulated Differentiation and Subsequent Glucose Starvation. Journal of Visualized Experiments : JoVE, (97). -
Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls
Zhang, H., Pu, W., Li, G., Huang, X., He, L., Tian, X., … Zhou, B. (2016). Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free Walls. CIRCULATION RESEARCH, 118(12), 1880-? -
Distilling complexity to advance cardiac tissue engineering
Ogle, B. M., Bursac, N., Domian, I., Huang, N. F., Menasche, P., Murry, C. E., … Vunjak-Novakovic, G. (2016). Distilling complexity to advance cardiac tissue engineering. SCIENCE TRANSLATIONAL MEDICINE, 8(342). -
iPSC-derived cardiomyocytes reveal abnormal TGF-ß signalling in left ventricular non-compaction cardiomyopathy.
Kodo, K., Ong, S.-G., Jahanbani, F., Termglinchan, V., Hirono, K., Inanloorahatloo, K., … Wu, J. C. (2016). iPSC-derived cardiomyocytes reveal abnormal TGF-ß signalling in left ventricular non-compaction cardiomyopathy. Nature Cell Biology, 18(10), 1031–42. -
Inhibition of Apoptosis Overcomes Stage-Related Compatibility Barriers to Chimera Formation in Mouse Embryos.
Masaki, H., Kato-Itoh, M., Takahashi, Y., Umino, A., Sato, H., Ito, K., … Nakauchi, H. (2016). Inhibition of Apoptosis Overcomes Stage-Related Compatibility Barriers to Chimera Formation in Mouse Embryos. Cell Stem Cell, 19(5), 587–92. -
Transcriptomic Profiling Maps Anatomically Patterned Subpopulations among Single Embryonic Cardiac Cells
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Integrative Analysis of PRKAG2 Cardiomyopathy iPS and Microtissue Models Identifies AMPK as a Regulator of Metabolism, Survival, and Fibrosis
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Mammalian Heart Regeneration: The Race to the Finish Line.
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Partial Reprogramming of Pluripotent Stem Cell-Derived Cardiomyocytes into Neurons
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Contractile force generation by 3D hiPSC-derived cardiac tissues is enhanced by rapid establishment of cellular interconnection in matrix with muscle-mimicking stiffness
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Untangling the Biology of Genetic Cardiomyopathies with Pluripotent Stem Cell Disease Models
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YY1 Expression is Sufficient for the Maintenance of Cardiac Progenitor Cell State.
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Strategies for the acquisition of transcriptional and epigenetic information in single cells.
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The relationship between cardiac endothelium and fibroblasts: it's complicated.
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In vivo rescue of the hematopoietic niche by pluripotent stem cell complementation of defective osteoblast compartments.
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Nkx2.5+?Cardiomyoblasts Contribute to Cardiomyogenesis in the Neonatal Heart.
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Reactivation of the Nkx2.5 cardiac enhancer after myocardial infarction does not presage myogenesis.
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Stage-specific Effects of Bioactive Lipids on Human iPSC Cardiac Differentiation and Cardiomyocyte Proliferation.
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Tissue Engineering of 3D Organotypic Microtissues by Acoustic Assembly.
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Bioengineering cardiac constructs using 3D printing
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Big bottlenecks in cardiovascular tissue engineering
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Prometheus Unbound in Ya(p) Heart
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Fates Aligned: Origins and Mechanisms of Ventricular Conduction System and Ventricular Wall Development
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Modelling inherited cardiac disease using human induced pluripotent stem cell-derived cardiomyocytes: progress, pitfalls, and potential
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Reassessment of c-Kit in Cardiac Cells A Complex Interplay Between Expression, Fate, and Function
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4D Printing of Actuating Cardiac Tissue
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Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function.
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Single Cell Analysis of Endothelial Cells Identified Organ-Specific Molecular Signatures and Heart-Specific Cell Populations and Molecular Features.
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Myopathy Causing Bag3P209L Protein Leads to Restrictive Cardiomyopathy Caused by Aggregate Formation and Sarcomere Disruption in Cardiomyocytes
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Hypertrophic Cardiomyopathy Mutations With Opposite Effects on [latin sharp s]-myosin Biomechanics Show Similar Structural and Biomechanical Phenotypes in Human Induced Pluripotent Stem Cell Derived Cardiomyocytes (hipsc-cms)
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Proceedings From the 2019 Stanford Single Ventricle Scientific Summit: Advancing Science for Single Ventricle Patients: From Discovery to Clinical Applications.
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Simple Lithography-Free Single Cell Micropatterning using Laser-Cut Stencils.
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Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response
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Cardiovascular Risks in Patients with COVID-19: Potential Mechanisms and Areas of Uncertainty.
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Levitating Cells to Sort the Fit and the Fat.
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Cardiovascular tissue bioprinting: Physical and chemical processes.
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Wnt Activation and Reduced Cell-Cell Contact Synergistically Induce Massive Expansion of Functional Human iPSC-Derived Cardiomyocytes.
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Ageing hallmarks exhibit organ-specific temporal signatures.
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Immune Checkpoint Inhibitor Cardiotoxicity: Understanding Basic Mechanisms and Clinical Characteristics and Finding a Cure.
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Intrinsic Endocardial Defects Contribute to Hypoplastic Left Heart Syndrome.
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4HNE Impairs Myocardial Bioenergetics in Congenital Heart DiseaseInduced Right Ventricular Failure.
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Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo.
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Purification of Pluripotent Stem Cell-Derived Cardiomyocytes Using CRISPR/Cas9-Mediated Integration of Fluorescent Reporters.
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Single-Cell RNA-seq Unveils Unique Transcriptomic Signatures of Organ-Specific Endothelial Cells.
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Myocardial Disease and Long-Distance Space Travel: Solving the Radiation Problem.
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Myocarditis Surveillance with High-Sensitivity Troponin I During Cancer Treatment with Immune Checkpoint Inhibitors.
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Single cell RNA sequencing approaches to cardiac development and congenital heart disease.
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Molecular Profiling of the Cardiac Conduction System: the Dawn of a New Era.
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Immune checkpoint inhibitor cardiotoxicity: Breaking barriers in the cardiovascular immune landscape.
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RNA splicing programs define tissue compartments and cell types at single cell resolution.
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Sequential Defects in Cardiac Lineage Commitment and Maturation Cause Hypoplastic Left Heart Syndrome.
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Tissue Engineering of 3D Organotypic Microtissues by Acoustic Assembly
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Molecular hallmarks of heterochronic parabiosis at single cell resolution
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The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans.
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Identification of Pathogenic Immune Cell Subsets Associated With Checkpoint Inhibitor-Induced Myocarditis.
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In vivo visualization and molecular targeting of the cardiac conduction system.
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Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation.
Galdos, F. X., Lee, C., Lee, S., Paige, S., Goodyer, W., Xu, S., … Wu, S. (2023). Combined lineage tracing and scRNA-seq reveals unexpected first heart field predominance of human iPSC differentiation. ELife, 12. -
Changes in myosin biomechanics influence growth and maturation of iPSC-cardiomyocytes
Bernstein, D., Vander Roest, A. S., Wu, S., Pruitt, B., Zhao, M., Fajardo, G., … Spudich, J. A. (2023). Changes in myosin biomechanics influence growth and maturation of iPSC-cardiomyocytes. BIOPHYSICAL JOURNAL. CELL PRESS. -
The Z-disc: Mechanosensor at the interface between myosin biomechanics and hypertrophic signaling
Giri, P., Roest, A. S. V., Lee, S., Heinrich, P., Dunn, A. R., Wu, S., & Bernstein, D. (2023). The Z-disc: Mechanosensor at the interface between myosin biomechanics and hypertrophic signaling. BIOPHYSICAL JOURNAL. CELL PRESS. -
Effects of changes in myosin biomechanics on canonical and non-canonical signaling and HCM phenotypes
Heinrich, P., & Wu, S. M. (2023). Effects of changes in myosin biomechanics on canonical and non-canonical signaling and HCM phenotypes. BIOPHYSICAL JOURNAL. CELL PRESS. -
The sum of the parts is greater than the whole: current research models for congenital heart disease.
Samad, T., & Wu, S. M. (2023). The sum of the parts is greater than the whole: current research models for congenital heart disease. . Nature Cardiovascular Research. -
Harnessing developmental cues for cardiomyocyte production.
Maas, R. G., van den Dolder, F. W., Yuan, Q., van der Velden, J., Wu, S. M., Sluijter, J. P., & Buikema, J. W. (2023). Harnessing developmental cues for cardiomyocyte production. Development (Cambridge, England), 150(15). -
Mechanisms in cardiac development and regeneration
Deutsch, M.-A., Doppler, S. A., Gummert, J. F., Wu, S. M., Krane, M., & Lange, R. (2023). Mechanisms in cardiac development and regeneration. ZEITSCHRIFT FUR HERZ THORAX UND GEFASSCHIRURGIE. -
Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5.
Liu, N., Kawahira, N., Nakashima, Y., Nakano, H., Iwase, A., Uchijima, Y., … Nakano, A. (2023). Notch and retinoic acid signals regulate macrophage formation from endocardium downstream of Nkx2-5. Nature Communications, 14(1), 5398. -
Osimertinib-Associated Cardiomyopathy In Patients With Non-Small Cell Lung Cancer: A Case Series
Franquiz, M., Waliany, S., Xu, A., Hnatiuk, A., Wu, S., Cheng, P., … Zhu, H. (2023). Osimertinib-Associated Cardiomyopathy In Patients With Non-Small Cell Lung Cancer: A Case Series. JACC: CardioOncology, 839–841. -
Massive expansion of functional human iPSC-derived cardiomyocytes by concomitant glycogen synthase kinase-3 beta inhibition and removal of cell-cell contact
Buikema, J. W., Lee, S., Maas, R. G. J., Van der Velden, J., Sluijter, J. P. G., & Wu, S. M. (2023). Massive expansion of functional human iPSC-derived cardiomyocytes by concomitant glycogen synthase kinase-3 beta inhibition and removal of cell-cell contact. EUROPEAN HEART JOURNAL. OXFORD UNIV PRESS. -
Notch and Retinoic Acid Signals Regulate Macrophage Formation From Endocardium Downstream of Nkx2-5
Liu, N., Kawahira, N., Nakashima, Y., Nakano, H., Iwase, A., Uchijima, Y., … Nakano, A. (2023). Notch and Retinoic Acid Signals Regulate Macrophage Formation From Endocardium Downstream of Nkx2-5. CIRCULATION RESEARCH. LIPPINCOTT WILLIAMS & WILKINS.
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Stanford, CAGeneral Cardiology at Boswell Building
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