Clinical Focus

• Cancer> Head and Neck Cancer
• Cancer> Radiation Oncology
• Lung Cancer - Radiation Oncology
• Salivary Gland Tumors - Radiation Oncology
• Head and Neck Cancers - Radiation Oncology

Administrative Appointments

• Editorial Board, Journal of Clinical Oncology (2005 - 2009)
• IMRT Practicum Course Co-Director, American Society of Therapeutic Oncology and Radiology (2004 - 2009)
• Educational Committee Vice Chair, American Society of Therapeutic Radiology and Oncology (2005 - present)
• Director of Clinial research, Department of radiation oncology, stanford university (2005 - present)
• Editorial Board, Int J Radiation Oncology Biology Physics (2003 - present)

Professional Education

Postdoctoral Advisees

Peiwen Kuo,  Nan Xiao

Graduate & Fellowship Program Affiliations

• Radiation Oncology

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information

Current Research Interests

My laboratory research interest focuses on the identification of biomarkers for prognosis in patients with head & neck or lung cancers. Current research goals are: to validate the prognostic significance of certain hypoxia markers using clinical samples from a randomized phase III clinical trial and to monitor the tumor burden of HPV-related head & neck cancers during therapy by tracking circulating HPV DNA in the blood. We are also looking to determine if plasma levels of MiR 210’s can predict tumor hypoxia in head and neck cancers, to dissect the function of Osteopontin in tumor progression, to target Galectin-1 (an immunomodulator) in combination with radiation in solid tumors, and to identify a microRNA signature in lung cancer. Additionally we are working to isolate human salivary gland stem cells for salivary gland function rescue after head & neck radiation therapy.
I am also conducting a number of clinical trials specifically in patients with head and neck cancer. I am conducting a multi-site phase II study of Lapatinib plus radiation for head & neck cancer patients who cannot tolerate chemotherapy, and participating in several RTOG cooperative group studies for this disease site.

Clinical Trials

• A Longitudinal Study of Plasma EBV DNA in Nasopharyngeal Carcinoma from Both Endemic and Non-Endemic Patient Populations Recruiting
• A Randomized Phase II Study of Adjuvant Concurrent Radiation and Chemotherapy versus Radiation Alone in Resected High-Risk Malignant Salivary Gland Tumors. Recruiting
• Feasibility of IMRT Modulation to Account for Scattered Radiation from Dental Fillings in H&N Cancer Recruiting
• Identification and Characterization of Novel Proteins in Head and Neck Cancer Recruiting
• Identification of Secreted Markers for Tumor Hypoxia in Patients with Head and Neck or Lung Cancers Recruiting

Publications

• Intrafraction Verification of Gated RapidArc by Using Beam-Level Kilovoltage X-Ray Images. Li R, Mok E, Chang DT, Daly M, Loo BW, Diehn M, Le QT, Koong A, Xing L. Int J Radiat Oncol Biol Phys. 2012
• Metabolic Tumor Volume is an Independent Prognostic Factor in Patients Treated Definitively for Non-Small-Cell Lung Cancer. Lee P, Bazan JG, Lavori PW, Weerasuriya DK, Quon A, Le QT, Wakelee HA, Graves EE, Loo BW. Clin Lung Cancer. 2012; 13 (1): 52-8
• Prognostic Value of Metabolic Tumor Volume and Velocity in Predicting Head-and-Neck Cancer Outcomes. Chu KP, Murphy JD, La TH, Krakow TE, Iagaru A, Graves EE, Hsu A, Maxim PG, Loo B, Chang DT, Le QT. Int J Radiat Oncol Biol Phys. 2012
• Prognostic and Predictive Significance of Plasma HGF and IL-8 in a Phase III Trial of Chemoradiation with or without Tirapazamine in Locoregionally Advanced Head and Neck Cancer. Le QT, Fisher R, Oliner KS, Young RJ, Cao H, Kong C, Graves E, Hicks RJ, McArthur GA, Peters L, O''Sullivan B, Giaccia A, Rischin D. Clin Cancer Res. 2012
• Quantitation of human papillomavirus DNA in plasma of oropharyngeal carcinoma patients. Cao H, Banh A, Kwok S, Shi X, Wu S, Krakow T, Khong B, Bavan B, Bala R, Pinsky BA, Colevas D, Pourmand N, Koong AC, Kong CS, Le QT. Int J Radiat Oncol Biol Phys. 2012; 82 (3): e351-8