Clinical Focus

• Pulmonary Critical Care
• Lung Transplantation
• Heart-Lung Transplantation
• Transplantation Immunology
• Pulmonary Hypertension

Administrative Appointments

• Chief, Pulmonary and Critical Care Medicine (2010 - present)
• Program Director, Pulmonary and Critical Care Fellowship (2009 - 2010)
• Faculty, Vera Moulton Wall Center For Pulmonary Vascular Disease (2007 - present)
• Member, Stanford Cardiovascular Institute (2007 - present)
• Director, Lung Immunology (2007 - present)

Professional Education

Postdoctoral Advisees

Xinguo Jiang,  Tom Nguyen,  Tom Nguyen,  Jin Qian,  Jin Qian,  Wen Tian,  Ke Yuan

Graduate & Fellowship Program Affiliations

• Immunology

Internet Links

• Nicolls Lab website

Current Research Interests

Our lab focuses primarily on the contribution of the immune response to lung disease. We are specifically examining the contribution of inflammation to the development of pulmonary hypertension. We also study how airway remodeling occurs in transplantation with specific respect to the microvascular circulation and to the initiation of fibroproliferation.

Publications

• Adenovirus-mediated HIF-1α gene transfer promotes repair of mouse airway allograft microvasculature and attenuates chronic rejection. Jiang X, Khan MA, Tian W, Beilke J, Natarajan R, Kosek J, Yoder MC, Semenza GL, Nicolls MR. J Clin Invest. 2011; 121 (6): 2336-49
• A Brief Overview of Mouse Models of Pulmonary Arterial Hypertension: Problems and Prospects. Gomez-Arroyo JG, Saleem SJ, Mizuno S, Syded AA, Bogaard HJ, Abbate A, Taraseviciene-Stewart L, Sung Y, Kraskauskas D, Farkas D, Conrad DH, Nicolls MR, Voelkel NF. Am J Physiol Lung Cell Mol Physiol. 2012
• CD4+ T cells and complement independently mediate graft ischemia in the rejection of mouse orthotopic tracheal transplants. Khan MA, Jiang X, Dhillon G, Beilke J, Holers VM, Atkinson C, Tomlinson S, Nicolls MR. Circ Res. 2011; 109 (11): 1290-301
• Inhibiting lung elastase activity enables lung growth in mechanically ventilated newborn mice. Hilgendorff A, Parai K, Ertsey R, Jain N, Navarro EF, Peterson JL, Tamosiuniene R, Nicolls MR, Starcher BC, Rabinovitch M, Bland RD. Am J Respir Crit Care Med. 2011; 184 (5): 537-46
• Regulatory T cells limit vascular endothelial injury and prevent pulmonary hypertension. Tamosiuniene R, Tian W, Dhillon G, Wang L, Sung YK, Gera L, Patterson AJ, Agrawal R, Rabinovitch M, Ambler K, Long CS, Voelkel NF, Nicolls MR. Circ Res. 2011; 109 (8): 867-79