Clinical Focus

• Neurological Surgery
• Movement Disorders
• Pain

Administrative Appointments

• Director, Stereotactic and Functional Neurosurgery (2004 - present)

Professional Education

Postdoctoral Advisees

Chethan Pandarinath

Graduate & Fellowship Program Affiliations

• Neurosciences
• Neurosurgery

Industry Relationships

Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information

Current Research Interests

My research interests encompass several areas of stereotactic and functional neurosurgery, including frameless stereotactic approaches for therapy delivery to deep brain nuclei; deformable patient-specific atlases for targeting brain structures; cortical physiology and its relationship to normal and pathological movement; neural prostheses; and the development of novel neuromodulatory techniques for the treatment of movement disorders, pain, and other neurological diseases.

Clinical Trials

• Braingate2 Recruiting
• Safety and Efficacy study of Intraputaminal and Intranigral Administration of CERE-120 (Gene transfer) in Subjects With Parkinson’s Disease No longer recruiting
• Safety and Efficacy Study of GAD Gene Transfer Therapy in Parkinson's disease Completed

Publications

• "Connectomic surgery": diffusion tensor imaging (DTI) tractography as a targeting modality for surgical modulation of neural networks. Henderson JM, Front Integr Neurosci. 2012: 6 15
• AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial. LeWitt PA, Rezai AR, Leehey MA, Ojemann SG, Flaherty AW, Eskandar EN, Kostyk SK, Thomas K, Sarkar A, Siddiqui MS, Tatter SB, Schwalb JM, Poston KL, Henderson JM, Kurlan RM, Richard IH, Van Meter L, Sapan CV, During MJ, Kaplitt MG, Feigin A. Lancet Neurol. 2011; 10 (4): 309-19
• Challenges and opportunities for next-generation intracortically based neural prostheses. Gilja V, Chestek CA, Diester I, Henderson JM, Deisseroth K, Shenoy KV. IEEE Trans Biomed Eng. 2011; 58 (7): 1891-9
• Probabilistic analysis of activation volumes generated during deep brain stimulation. Butson CR, Cooper SE, Henderson JM, Wolgamuth B, McIntyre CC. Neuroimage. 2011; 54 (3): 2096-104
• Alpha-synuclein suppression by targeted small interfering RNA in the primate substantia nigra. McCormack AL, Mak SK, Henderson JM, Bumcrot D, Farrer MJ, Di Monte DA. PLoS One. 2010; 5 (8): e12122