Hayley Gans
Academic Appointments
- Assistant Professor - Med Center Line, Pediatrics - Infectious Diseases
- Member, Child Health Research Institute
Key Documents
Contact Information
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Clinical Offices
Pediatric Infectious Disease 730 Welch Rd 2nd Floor MC 5884 Palo Alto, CA 94304 Tel Work (650) 721-5805 Fax (650) 725-8040Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Alternate Contact Kelley Nelson Administrative Assistant Email Tel Work 650-723-5682Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Infectious Diseases, Pediatric
- Pediatric Infectious Disease
Professional Education
| Residency: | Stanford University Medical Center CA (1994) |
| Fellowship: | Stanford University School of Medicine CA (1998) |
| Board Certification: | Pediatric Infectious Disease, American Board of Pediatrics (1999) |
| Medical Education: | State University of New York NY (1991) |
| M.D.: | SUNY at Syracuse, Medicine (1991) |
Graduate & Fellowship Program Affiliations
Scientific Focus
Current Research Interests
The focus of my laboratory is defining the immune response to viral vaccines evaluating the ontogeny of responses in infants and limitations in immunocompromised hosts. We have studied the memory effector T cells response in infants given an early two-dose measles vaccine regimen, measuring CD4+, CD4+CD45RO+ and CD4+CD45RO+CCR7-T cells that produce IFN. We have also analyzed key markers of activation, using cell surface markers CD69 and CD40-ligand. In addition, we have studied innate immunity and the interactions with the adaptive immune system. We have measured dendritic cell and monocyte populations and function in infants and children and the effects on measles-specific CD4+ T cell responses. These analyses have also been applied to both term and preterm infants receiving polio vaccine, and children receiving varicella vaccination. Our findings have revealed relative limitations in both the innate and adaptive immune system of healthy infants and children as compared with adults. Currently, we are investigating mechanisms responsible for these restrictions. We are also examining the acquisition and persistence of viral immunity in two immunocompromised states, HIV infection and transplantation. The goals of these studies are to define immune profiles in populations where obstacles to vaccination exist to offer insights for the development of novel vaccine strategies.
Publications
- Measles humoral and cell-mediated immunity in children aged 5-10 years after primary measles immunization administered at 6 or 9 months of age. J Infect Dis. 2013; (4): 574-82
- The status of live viral vaccination in early life. Vaccine. 2013; (21): 2531-7
- Preterm infants' T cell responses to inactivated poliovirus vaccine. J Infect Dis. 2010; (2): 214-22
- Age-related increase in the frequency of CD4(+) T cells that produce interferon-gamma in response to staphylococcal enterotoxin B during childhood. J Infect Dis. 2009; (12): 1921-7
- Effects of interleukin-12 and interleukin-15 on measles-specific T-cell responses in vaccinated infants. Viral Immunol. 2008; (2): 163-72
- Eosinophilic meningoencephalitis: psychiatric presentation and treatment. Int J Psychiatry Med. 2008; (3): 287-95
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