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Hayley Gans

Academic Appointments

  • Assistant Professor of Pediatrics (Infectious Diseases) at the Lucile Salter Packard Children's Hospital

Key Documents

Contact Information

  • Clinical Offices
    Pediatric Infectious Disease 730 Welch Rd 2nd Fl MC 5884 Palo Alto, CA 94304
    Tel Work (650) 721-5805 Fax (650) 725-8040
  • Academic Offices
    Personal Information
    Tel (650) 725-8935
    Alternate Contact
    Valerie Berland Administrative Assistant Tel Work 650-723-5682
    Not for medical emergencies or patient use

Professional Overview

Clinical Focus

  • Infectious Diseases, Pediatric
  • Pediatric Infectious Disease

Academic Appointments

Professional Education

Medical Education: State University of New York at Syracuse NY (1991)
Internship: Stanford University Medical Center CA (1992)
Residency: Stanford University Medical Center CA (1994)
Fellowship: Stanford University School of Medicine CA (1998)
Board Certification: Pediatric Infectious Disease, American Board of Pediatrics (1999)
M.D.: SUNY at Syracuse, Medicine (1991)

Courses

2013-14

Postdoctoral Advisees

Megumi ItohAlexander Kay

Graduate and Fellowship Program Affiliations

Scientific Focus

Current Research and Scholarly Interests

The focus of my laboratory is defining the immune response to viral vaccines evaluating the ontogeny of responses in infants and limitations in immunocompromised hosts. We have studied the memory effector T cells response in infants given an early two-dose measles vaccine regimen, measuring CD4+, CD4+CD45RO+ and CD4+CD45RO+CCR7-T cells that produce IFN. We have also analyzed key markers of activation, using cell surface markers CD69 and CD40-ligand. In addition, we have studied innate immunity and the interactions with the adaptive immune system. We have measured dendritic cell and monocyte populations and function in infants and children and the effects on measles-specific CD4+ T cell responses. These analyses have also been applied to both term and preterm infants receiving polio vaccine, and children receiving varicella vaccination. Our findings have revealed relative limitations in both the innate and adaptive immune system of healthy infants and children as compared with adults. Currently, we are investigating mechanisms responsible for these restrictions. We are also examining the acquisition and persistence of viral immunity in two immunocompromised states, HIV infection and transplantation. The goals of these studies are to define immune profiles in populations where obstacles to vaccination exist to offer insights for the development of novel vaccine strategies.

Clinical Trials

Publications

Publication tag cloud

Publication Topics

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