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Frank M. Longo, M.D., Ph.D.

Academic Appointments

  • George E. and Lucy Becker Professor in Medicine and Professor, by courtesy, of Neurosurgery

Key Documents

Contact Information

  • Clinical Offices
    Neurology Department 300 Pasteur Dr H3160 MC 5235 Stanford, CA 94305
    Tel Work (650) 723-6469 Fax (650) 725-7459
  • Academic Offices
    Personal Information
    Email Tel (650) 724-3172
    Alternate Contact
    Julie Schumacher Admin Associate Tel Work 650-724-3172
    Not for medical emergencies or patient use

Professional Overview

Clinical Focus

  • Neurology
  • Alzheimer's Disease
  • Huntington Disease

Academic Appointments

Administrative Appointments

  • Professor and Chair, Department of Neurology and Neurological Sciences, Stanford University (2006 - present)
  • Professor and Chair, Department of Neurology, University of North Carolina, Chapel Hill (2001 - 2005)
  • Professor and Vice Chair, UC San Francisco (1999 - 2001)
  • Assoc. Chief of Staff for Research and Dev., SF, VAMC (1997 - 2001)
  • Assoc. Professor and Vice Chair, UC San Francisco (1996 - 1999)
  • Chief, Neurology and Rehab Services, SF, VAMC (1995 - 2001)

Honors and Awards

  • Stanford University Fellow, Stanford University (2006-2008)
  • Outstanding Alumnus Award, UC San Diego (2000)
  • Associate Editor, Annals of Neurology (1994-1997)
  • Beeson Award, American Federation for Aging Research (1995)
  • Edwin Boldrey Award for Basic Science Research, San Francisco Neurological Society (1990)
  • First Place in Neuroscience, National Student Research Forum (1979)

Professional Education

Residency: UCSF Medical Center CA (1987)
Medical Education: UCSD School of Medicine CA (1981)
Board Certification: Neurology, American Board of Psychiatry and Neurology (1989)
Internship: New York VA Medical Center NY (1984)
Ph.D.: UC San Diego, Neuroscience (1983)
M.D.: UC San Diego, Medicine (1981)
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Courses

2013-14

Prior Year Coursescourses of Frank Longo

Graduate and Fellowship Program Affiliations

Scientific Focus

Current Research and Scholarly Interests

Clinical interests include Alzheimer’s disease and Huntington’s disease and the development of effective therapeutics for these disorders.

Our research group is focused on the discovery of cellular signaling mechanisms that serve as a basis for the development of novel therapeutic approaches for Alzheimer’s disease, Huntington’s disease and other neurological disorders. In our Neurotrophin Program, we have pioneered the development of small molecule ligands targeted to neurotrophin receptors to promote novel signaling mechanisms. Small molecule-induced activation of these mechanisms demonstrates therapeutic efficacy in models of Alzheimer’s disease, Huntington’s disease, Parkinson’s disease, spinal cord injury, amyotrophic lateral sclerosis (ALS), HIV dementia and other areas. These novel compounds also promote neurogenesis from stem cells.

In our Protein Tyrosine Phosphatase Receptor Program we have elucidated the role of protein tyrosine phosphatase (PTP) receptors in the nervous system by focusing on LAR, a prototype PTP receptor that we discovered to be expressed in the nervous system. Our studies demonstrated the first CNS and PNS phenotypes in a PTP receptor mutant mouse, discovered PTP extracellular domains responsible for their potent neurite promoting effects, found that LAR associates with Trk neurotrophin receptors to regulate their activity, showed that down regulating LAR promotes stem cell proliferation and stimulates hippocampal neurogenesis, and developed a novel approach for down regulating PTP activity. This work reveals additional candidate therapeutic targets for small molecule development.

Publications

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Publication Topics

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