Emmanuel Mignot
Academic Appointments
- Professor, Psychiatry & Behavioral Science - Sleep Center
- Member, Bio-X
Key Documents
Contact Information
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Clinical Offices
Stanford Sleep Medicine Center 450 Broadway St Pavilion C, 2nd Flr, MC:5704 Redwood City, CA 94063 Tel Work (650) 723-6601 Fax (650) 721-3447
- Academic Offices
Personal Information Email Tel (650) 725-6517Alternate Contact Jennifer Kouragian Assistant Email Tel Work 650-725-6517Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Narcolepsy Cataplexy Syndrome
- Kleine-Levin Syndrome
- Sleep Medicine
Administrative Appointments
- Director, Center For Narcolepsy (1989 - 2015)
- Director, Center For Sleep Sciences and Medicine (2010 - 2015)
Honors and Awards
- Elected member, Institute of Medicine (2006)
- Sleep Research Society, Outstanding Scientific Achievement Award (2006)
- W. Alden Spencer Award, College of Physicians and Surgeons of Columbia University (2004)
- Foster Elting Bennett Memorial Lecture Award, American Neurological Association (2004)
- Investigator Award, Howard Hughes Medical Institute (2002-2010)
- Neuroscience of Brain Disorders Award, McKnight Foundation (2002)
Professional Education
| Board Certification: | Sleep Medicine, American Board of Sleep Medicine (1990) |
| Residency: | Necker Enfants Malades Hospital, France (1989) |
| Fellowship: | Stanford University School of Medicine CA (1996) |
| Medical Education: | University Of Paris, France (1985) |
Graduate & Fellowship Program Affiliations
Community and International Work
- GWAS studies in narcolepsy and KleineLevin, International
- immunochip, International
Internet Links
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information
Scientific Focus
Current Research Interests
1) Clinical/outcome studies in various sleep disorders, with use of web based evaluation tools and genetics
2) Human genetic studies in sleep disorders (GWAS, sequencing):
-Narcolepsy
-Kleine Levin syndrome
-Rare familial syndromes with sleep disturbances
3) Immunological and microbiomic studies in human narcolepsy and Kleine Levin syndrome
-Isolation of biomarkers such as autoantibodies, genome wide expression
-Sequencing studies of the TCR repertoire
4) EEG signal processing analysis for automatic scoring and discovery of novel disease bio markers for neuropsychiatric disorders and clinical applications in sleep disorders medicine
Genetic basis of the response to hypoxia and hypercapnia
Publications
- HLA-DQ association and allele competition in Chinese narcolepsy. Tissue Antigens. 2012; (4): 328-35
- Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy. Hum Mol Genet. 2012; (10): 2205-10
- Common variants in P2RY11 are associated with narcolepsy. Nat Genet. 2011; (1): 66-71
- Genetics of sleep and sleep disorders. Cell. 2011; (2): 194-207
- Narcolepsy onset is seasonal and increased following the 2009 H1N1 pandemic in China. Ann Neurol. 2011; (3): 410-7
- IGFBP3 colocalizes with and regulates hypocretin (orexin). PLoS One. 2009; (1): e4254
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