Anthony Oro MD/PhD
Academic Appointments
- Professor, Dermatology
- Member, Bio-X
- Member, Child Health Research Institute
- Member, Stanford Cancer Institute
Key Documents
Contact Information
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Clinical Offices
Adult Dermatology Clinic 450 Broadway Street, Pavilion B MC 5334 Redwood City, CA 94063 Tel Work (650) 723-6316 Fax (650) 721-3476
- Academic Offices
Personal Information Email Tel (650) 725-7022Alternate Contact Ray Herrman administrative assistant Email Tel Work 650-725-7022Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Cancer> Cutaneous (Dermatologic) Oncology
- Dermatology
- Skin Cancer
- Hair disorders
Professional Education
| Residency: | Stanford University Medical Center CA (1997) |
| Board Certification: | Dermatology, American Board of Dermatology (1998) |
| Internship: | Stanford University Medical Center CA (1994) |
| Medical Education: | UCSD School of Medicine CA (1993) |
Postdoctoral Advisees
Scott Atwood, Susie Lee, Lingjie Li, Sandra Melo Carlos, Ramon Whitson, Gozde Yucel
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
Our lab studies skin stem cells to understand mechanisms of tissue regeneration and carcinogenesis. We have a longstanding interest in the mechanisms of Sonic hedgehog (Shh) signaling in the hair follicle and n the pathogenesis of the most common human tumor, basal cell carcinoma (BCCs) of the skin. We have provided clinical evidence for the first hedgehog pathway inhibitor and are developing novel targets for next generation inhibitors that target the transcription factor Gli. We are studying the mechanisms of tumor evolution and the development of chemoresistance to targeted agents in both patients and mouse models using genomics and bioinformatic methods followed by functional validation.
We are also interested in the mechanisms of human skin development and early ectodermal differentiation and have developed in vitro human skin differentiation from embryonic stem cells. Using this system, we are exploring how early ectoderm commits to stratified epithelium. We have used our system, in collaboration with other labs at Stanford, to manufacture corrected human epidermal sheets from patient-specific iPS cells.
Clinical Trials
- Recruiting Characteristics of Patients With Dystrophic Epidermolysis Bullosa
- Recruiting Pilot LDE225 in Locally Advanced or Metastatic BCC + Previously Tx Non-LDE225 Smoothened Inhibitors
- Not Recruiting A Study Evaluating the Efficacy and Safety of Vismodegib (GDC-0449, Hedgehog Pathway Inhibitor) in Patients With Advanced Basal Cell Carcinoma
- Not Recruiting A Study of GDC-0449 (Hedgehog Pathway Inhibitor) in Patients Treated With GDC-0449 in a Previous Genentech-Sponsored Phase I or II Cancer Study
- Not Recruiting A Phase II Study of Efficacy and Safety in Patients With Locally Advanced or Metastatic Basal Cell Carcinoma
Publications
- Efficacy and safety of vismodegib in advanced basal-cell carcinoma. N Engl J Med. 2012; (23): 2171-9
- Shh maintains dermal papilla identity and hair morphogenesis via a Noggin-Shh regulatory loop. Genes Dev. 2012; (11): 1235-46
- Translocation affecting sonic hedgehog genes in basal-cell carcinoma. N Engl J Med. 2012; (23): 2233-4
- I-BAR protein antagonism of endocytosis mediates directional sensing during guided cell migration. J Cell Biol. 2010; (2): 353-67
- MIM and cortactin antagonism regulates ciliogenesis and hedgehog signaling. Dev Cell. 2010; (2): 270-83
- Cell migration: GSK3β steers the cytoskeleton's tip. Cell. 2011; (3): 319-21
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