Epilepsy Program

Epilepsy Research

Our physician-researchers and scientists are pioneers in making discoveries through studying the causes of epilepsy, its surgical treatment options, non-epileptic psychogenic seizures that mimic epilepsy, and innovative methods to treat intractable epilepsy, such as electrical stimulation. They are currently engaged in groundbreaking studies on the causes of epilepsy, the effect of seizures and medications on human cognition and emotion, and developing new wireless devices and electrodes for epilepsy treatment.

While each member of our Comprehensive Epilepsy Program team is involved in various clinical or basic science research projects, there are four active program laboratories, where a group of investigators conduct systematic research funded by the National Institute of Health.

Research teams at the following laboratories are currently studying:

Buckmaster Laboratory

Temporal lobe epilepsy is common, frequently refractory to treatment, and devastating to those affected. Our long-term goal is to better understand the pathophysiological mechanisms of this disease so that rational and effective therapies can be developed. We use electrophysiological, molecular, and anatomical techniques to evaluate neuronal circuitry in normal and in epileptic brains.

Huguenard Laboratory

We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy.

Our approach is an analysis of the discrete components that make up thalamic and cortical circuits, and reconstitution of components into both in vitro biological and in silico computational networks. Accordingly, we have been able to identify genes whose products, mainly ion channels, play key roles in the regulation of thalamocortical network responses.

Parvizi Laboratory

The general theme of our research is the study of the human brain from clinical and system neuroscience perspective using the tools of intracranial electrocorticography (ECoG), electrical brain stimulation (EBS), and functional imaging (fMRI).  The main impetus for our research is to understand the anatomical and physiological signatures of behavioral expression and cognitive experience in humans and how these might be broken in patients with epilepsy. Using our sophisticated research tools, our goal is to help patients with uncontrolled epilepsy to gain seizure freedom without cognitive deficits.

Prince Laboratory

Work in the Prince lab has focused on normal and abnormal regulation of excitability in neurons of mammalian cerebral cortex and thalamus and mechanisms underlying development and prophylaxis of epilepsy in animal models. Long-term goals are to understand how cortical injury and other pathological processes induce changes in structure and function of neurons and neuronal networks that lead to hyperexcitability and epileptogenesis. With this information, it will be possible to devise experimental strategies to prevent the occurrence of epilepsy after cortical injury and eventually apply them to individuals with significant brain trauma. We have already provided a proof in principal that prophylaxis of posttraumatic epilepsy is possible, using a rat model.

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