Epilepsy Program

Publications - John Huguenard, PhD

Huguenard JR, McCormick DA (2007) Thalamic synchrony and dynamic regulation of global forebrain oscillations. Trends Neurosci. 30:350-6.

Schofield, C. M. and Huguenard, J.R. (2007) GABA Affinity Shapes IPSCs in Thalamic Nuclei. J. Neurosci. 27:7954-62

Pangratz-Fuehrer SM, Rudolph U, and Huguenard JR (2007) Giant spontaneous depolarizing potentials in the developing thalamic reticular nucleus. J. Neurophysiol. 97: 2364-2372.

Kumar, S.S., Jin, X., Buckmaster, P.S. and Huguenard, J.R. (2007) Recurrent circuits in layer II of medial entorhinal cortex in a model of temporal lobe epilepsy. J. Neurosci. 27:1239-1246.

Li, H., Huguenard, J.R., and Fisher, R.S. (2007) Gender and age differences in expression of GABAA receptor subunits in rat somatosensory thalamus and cortex in an absence epilepsy model. Neurobiol. of Disease, 25:623-30.

Tani, H., Bandrowski, A.E., Parada, I., Wynn, M., Huguenard, J.R. Prince, D.A. and Reimer, R.J. (2007) Modulation of epileptiform activity by glutamine and system A transport in a model of post-traumatic epilepsy. Neurobiol. Disease, 25:230-8.

Brill, J., Kwakye, G. and Huguenard, J.R. (2007) NPY signaling through Y1 receptors modulates thalamic oscillations. Peptides, 28:250-256.

Staley, K.J. and Huguenard, J.R. (2006) A thalamic sleep tonic. Epilepsy Currents. 6:164-166.

Deleuze, C. and Huguenard, J.R. (2006) Distinct electrical and chemical connectivity maps in the thalamic reticular nucleus: potential roles in synchronization and sensation. J Neurosci 26:8633-8645.

Li, H., Kraus, A., Wu, J., Huguenard, J.R., and Fisher, R.S. (2006) Selective changes in thalamic and cortical GABAA receptor subunits in a model of acquired absence epilepsy in the rat.
Neuropharmacology 51:121-128

Sohal, V.S., Pangratz-Fuehrer, S., Rudolph, U. and Huguenard, J.R. (2006) Intrinsic and synaptic dynamics interact to generate emergent patterns of rhythmic bursting in thalamocortical neurons. J Neurosci 26:4247-4255.

Jin, X., Prince, D.A. and Huguenard, J.R. (2006) Enhanced excitatory synaptic connectivity in layer V pyramidal neurons of chronically injured epileptogenic neocortex in rats. J Neurosci. 26:4891-4900.

Brill, J., Lee, M., Zhao, S., Fernald, R.D. and Huguenard, J.R. (2006) Chronic valproic acid treatment triggers increased neuropeptide Y expression and signaling in rat nucleus reticularis thalami. J. Neurosci, 26:6813-6822.

Sohal, V.S and Huguenard, J.R. (2005) Inhibitory coupling specifically generates emergent gamma oscillations in diverse cell types. PNAS 102:18638-43.

Bacci, A and Huguenard, J.R. (2005) Enhancement of spike precision by autaptic transmission in neocortical inhibitory interneurons. Neuron 49:119-130.

Jin X, Huguenard JR, Prince DA (2005) Impaired Cl- extrusion in layer V pyramidal neurons of chronically injured epileptogenic neocortex. J. Neurophysiol 93:2117-26.

Bacci, A., Huguenard, J.R. and Prince, D.A. (2004) Long-lasting self-inhibition of neocortical interneurons mediated by endocannabinoids. Nature, 431:312-316.

Huguenard, J.R. (2004) T Channel Defects in Patients With Childhood Absence Epilepsy. Epilepsy Currents, 4:7-8.

Sohal, V.S., Keist, R., Rudolph, U. and Huguenard, J.R. (2003) Inhibitory interconnections control burst pattern and emergent network synchrony in reticular thalamus, J. Neurosci. 23:8978-8988.

Sun,Q-Q., Baraban, S, Prince, D.A.and Huguenard, J.R. (2003) Target-specific NPYergic synaptic inhibition and its network consequences within the mammalian thalamus. J. Neurosc. 23:9639-9649.

Huguenard, J.R. (2003) Neurotransmitter Supply and Demand. Epilepsy Currents, 3:61-63.

Sohal, V.S., Keist, R., Rudolph, U. and Huguenard, J.R. (2003) Dynamic GABAA receptor subtype-specific modulation of the synchrony and duration of thalamic oscillations. J. Neurosci., 23:3649-3657.

Porcello, D.M., Smith, S.D. and Huguenard, J.R. (2003) Actions of U-92032, a T-type Ca2+ channel antagonist, support a functional linkage between IT and slow intrathalamic rhythms. J. Neurophysiol. 89: 177-185

Bacci, A., Huguenard, J.R., Prince, D.A. (2002) Differential Modulation of Synaptic Transmission by Neuropeptide Y in Rat Neocortical Neurons. Proc. Natl. Acad. Sci. U.S.A. 99: 17125-17130.

Lin, S. H. S., Arai, A. C., España, R. A., Berridge, C. W., Leslie, F. M., Huguenard, J. R., Vergnes, M. and Civelli, O. (2002) Prolactin-releasing peptide (PrRP) promotes awakening and suppresses absence seizures. Neuroscience, 114:229-238.

Huguenard, J.R. (2002) Block of T-type Ca2+ Channels is an Important Action of Succinimide Anti-Absence Drugs, Epilepsy Currents 2:49-52.

Sun, Q.Q., Huguenard, J.R. and Prince, D.A. (2002) Somatostatin inhibits thalamic network oscillations in vitro: Actions on the GABAergic neurons of the reticular nucleus. J. Neurosci., 22:5374-5386.

Kumar, S.S., Bacci, A., Kharazia, V. and Huguenard, J.R. (2002) A developmental switch of AMPA-receptor subunits in neocortical pyramidal neurons. J. Neurosci. 22:3005-3015.

Huguenard, J.R. (2001) Cortical output and epileptiform thalamocortical synchrony. Epilepsy Currents 1:13-14.

Sohal, V.S. and Huguenard, J.R. (2001) It takes T to tango. Neuron, 31:3-4.

Jacobsen, R.J., Ulrich, D. and Huguenard, J.R. (2001) GABAB and NMDA receptors contribute to spindle-like oscillations in rat thalamus in vitro. J. Neurophysiol. 86:1365-1375.

Yue, B.W. and Huguenard, J.R. (2001) The role of H-current in regulating strength and frequency of thalamic network oscillations. Thalamus. 1:95-103.

Huguenard, J.R. (2000) Circuit mechanisms of spike-wave discharge: Are there similar underpinnings for centrotemporal spikes? Epilepsia. 41:1076-1077.

Sohal, V.S., Huntsman, M.M., and Huguenard, J.R. (2000) Reciprocal inhibitory connections regulate the spatiotemporal properties of intrathalamic oscillations. J. Neurosci. 20:1735 1745.

Huguenard, J.R. (1999) Neuronal circuitry of thalamocortical epilepsy and mechanisms of antiabsence drug action. Adv Neurol 79:991-9.

Huntsman, M.M., Porcello, D.M., Homanics, G.E., DeLorey, T.M. and Huguenard, J.R. (1999) Reciprocal inhibitory connections and network synchrony in the mammalian thalamus. Science. 283:541-543.

Xiang, Z., Huguenard, J.R. and Prince, D.A. (1998) Cholinergic switching within neocortical inhibitory networks. Science. 281:985-988.

Sohal, V.S. and Huguenard, J.R. (1998) Long-range connections synchronize rather than spread intrathalamic oscillations: computational modeling and in vitro electrophysiology. J. Neurophysiol. 80:1736-1751.

Ulrich, D. and Huguenard, J.R. (1995) Purinergic inhibition of GABA and glutamate release in the thalamus: implications for thalamic network activity. Neuron 15:909-918.

Huguenard, J.R. and Prince, D.A. (1994) Clonazepam suppresses GABAB-mediated inhibition in thalamic relay neurons through effects in nucleus reticularis. J. Neurophysiol. 71:2576-2581.

Huguenard, J.R. and Prince, D.A. (1994) Intrathalamic rhythmicity studied in vitro: nominal T current modulation causes robust anti-oscillatory effects. J. Neurosci. 14:5485-5502.

Coulter, D.A., Huguenard, J.R., and Prince, D.A. (1991) Mechanism of block of thalamic T-type Ca2+ channels by petit mal anticonvulsants. Exp. Brain Res., 20: 201-204.

Coulter, D.A., Huguenard, J.R., and Prince, D.A. (1990) Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: calcium current reduction. Br. J. Pharmacol., 100: 800-806.

Coulter, D.A., Huguenard, J.R., and Prince, D.A. (1990) Differential effects of petit mal anticonvulsants and convulsants on thalamic neurones: GABA current blockade. Br. J. Pharmacol., 100: 807-813.

Coulter, D.A., Huguenard, J.R., and Prince, D.A. (1989) Specific petit mal anticonvulsants reduce calcium currents in thalamic neurons. Neurosci. Lett., 98: 74-78.

Stanford Medicine Resources:

Footer Links: